| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 11,297 |
| 2 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 7,201 |
| 3 | Inflammation and cancer: back to Virchow? | Lancet, The | 2001 | 6,834 |
| 4 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,546 |
| 5 | The chemokine system in diverse forms of macrophage activation and polarization | Trends in Immunology | 2004 | 5,417 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 7 | Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes | Trends in Immunology | 2002 | 4,636 |
| 8 | COVID-19 and Italy: what next? | Lancet, The | 2020 | 2,473 |
| 9 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,324 |
| 10 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,178 |
| 11 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,824 |
| 12 | Smoldering and polarized inflammation in the initiation and promotion of malignant disease | Cancer Cell | 2005 | 1,640 |
| 13 | The role of inflammation in epilepsy | Nature Reviews Neurology | 2011 | 1,500 |
| 14 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,491 |
| 15 | A mechanosensory complex that mediates the endothelial cell response to fluid shear stress | Nature | 2005 | 1,488 |
| 16 | Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,316 |
| 17 | Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy | European Journal of Cancer | 2006 | 1,302 |
| 18 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,268 |
| 19 | Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration | Journal of Cell Biology | 1998 | 1,263 |
| 20 | Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation | Science | 2000 | 1,194 |
| 21 | CAESAR models for developmental toxicity | Chemistry Central Journal | 2010 | 1,192 |
| 22 | Atypical Hemolytic–Uremic Syndrome | New England Journal of Medicine | 2009 | 1,168 |
| 23 | How to increase value and reduce waste when research priorities are set | Lancet, The | 2014 | 1,146 |
| 24 | Pathophysiology of Progressive Nephropathies | New England Journal of Medicine | 1998 | 1,145 |
| 25 | Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis | Physiological Reviews | 2004 | 1,134 |
| 26 | VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells | Cell | 2006 | 1,101 |
| 27 | Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 1,045 |
| 28 | Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products | Blood | 1992 | 1,041 |
| 29 | Endothelial cell–cell junctions: happy together | Nature Reviews Molecular Cell Biology | 2004 | 1,026 |
| 30 | The Italian SF-36 Health Survey | Journal of Clinical Epidemiology | 1998 | 1,004 |
| 31 | Albumin Replacement in Patients with Severe Sepsis or Septic Shock | New England Journal of Medicine | 2014 | 989 |
| 32 | The origin and function of tumor-associated macrophages | Trends in Immunology | 1992 | 975 |
| 33 | Preventing Microalbuminuria in Type 2 Diabetes | New England Journal of Medicine | 2004 | 956 |
| 34 | Panethnic Differences in Blood Pressure in Europe: A Systematic Review and Meta-Analysis | PLoS ONE | 2016 | 942 |
| 35 | Neurotoxicity of a prion protein fragment | Nature | 1993 | 939 |
| 36 | Brain Inflammation in Epilepsy: Experimental and Clinical Evidence | Epilepsia | 2005 | 938 |
| 37 | Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 936 |
| 38 | Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis | British Journal of Cancer | 2015 | 922 |
| 39 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 919 |
| 40 | Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype | Clinical Journal of the American Society of Nephrology: CJASN | 2010 | 851 |
| 41 | Functionally specialized junctions between endothelial cells of lymphatic vessels | Journal of Experimental Medicine | 2007 | 850 |
| 42 | Delayed graft function in kidney transplantation | Lancet, The | 2004 | 848 |
| 43 | The role of adherens junctions and VE-cadherin in the control of vascular permeability | Journal of Cell Science | 2008 | 833 |
| 44 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 825 |
| 45 | Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases | Journal of Neuroscience | 2003 | 810 |
| 46 | Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria | Lancet, The | 1999 | 809 |
| 47 | Role of tumor-associated macrophages in tumor progression and invasion | Cancer and Metastasis Reviews | 2006 | 805 |
| 48 | Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 801 |
| 49 | Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures | Nature Medicine | 2010 | 795 |
| 50 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 788 |
