| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 3 | A mechanosensory complex that mediates the endothelial cell response to fluid shear stress | Nature | 2005 | 1,457 |
| 4 | Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome | New England Journal of Medicine | 2013 | 1,258 |
| 5 | Pathophysiology of Progressive Nephropathies | New England Journal of Medicine | 1998 | 1,137 |
| 6 | Preventing Microalbuminuria in Type 2 Diabetes | New England Journal of Medicine | 2004 | 952 |
| 7 | Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype | Clinical Journal of the American Society of Nephrology: CJASN | 2010 | 818 |
| 8 | The role of adherens junctions and VE-cadherin in the control of vascular permeability | Journal of Cell Science | 2008 | 808 |
| 9 | Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria | Lancet, The | 1999 | 800 |
| 10 | Mesenchymal Stem Cells Are Renotropic, Helping to Repair the Kidney and Improve Function in Acute Renal Failure | Journal of the American Society of Nephrology: JASN | 2004 | 690 |
| 11 | Glia and epilepsy: excitability and inflammation | Trends in Neurosciences | 2013 | 656 |
| 12 | How Does Proteinuria Cause Progressive Renal Damage? | Journal of the American Society of Nephrology: JASN | 2006 | 647 |
| 13 | An image-based modeling framework for patient-specific computational hemodynamics | Medical and Biological Engineering and Computing | 2008 | 621 |
| 14 | Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy | Neurobiology of Disease | 2008 | 618 |
| 15 | Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial | Lancet, The | 2010 | 613 |
| 16 | Angiotensin II revisited: new roles in inflammation, immunology and aging | EMBO Molecular Medicine | 2010 | 595 |
| 17 | Understanding the nature of renal disease progression | Kidney International | 1997 | 572 |
| 18 | Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 | Nature Cell Biology | 2008 | 538 |
| 19 | Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 536 |
| 20 | Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial | Lancet, The | 1998 | 522 |
| 21 | Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes | Journal of Clinical Investigation | 2006 | 512 |
| 22 | KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer | British Journal of Cancer | 2009 | 509 |
| 23 | Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis | Journal of Experimental Medicine | 2003 | 481 |
| 24 | The role of cytokines in the pathophysiology of epilepsy | Brain, Behavior, and Immunity | 2008 | 474 |
| 25 | The microtubule-affecting drug paclitaxel has antiangiogenic activity | Clinical Cancer Research | 1996 | 466 |
| 26 | Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus | European Journal of Neuroscience | 2000 | 448 |
| 27 | Nitric Oxide Synthesis by Cultured Endothelial Cells Is Modulated by Flow Conditions | Circulation Research | 1995 | 442 |
| 28 | Disruption of the Ang II type 1 receptor promotes longevity in mice | Journal of Clinical Investigation | 2009 | 434 |
| 29 | Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: A global perspective | Kidney International | 2006 | 414 |
| 30 | Pretransplant Infusion of Mesenchymal Stem Cells Prolongs the Survival of a Semiallogeneic Heart Transplant through the Generation of Regulatory T Cells | Journal of Immunology | 2008 | 405 |
| 31 | Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction | Circulation | 2004 | 402 |
| 32 | Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura | Kidney International | 2001 | 399 |
| 33 | Platelet Dysfunction in Renal Failure | Seminars in Thrombosis and Hemostasis | 2004 | 393 |
| 34 | Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies | Kidney International | 1998 | 378 |
| 35 | Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials | BMJ: British Medical Journal | 1998 | 377 |
| 36 | Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. | Journal of Clinical Investigation | 1998 | 377 |
| 37 | Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148 | Journal of Cell Biology | 2003 | 374 |
| 38 | Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation | Kidney International | 1998 | 371 |
| 39 | Prognosis of Untreated Patients with Idiopathic Membranous Nephropathy | New England Journal of Medicine | 1993 | 370 |
| 40 | Effect of Low-Dose Aspirin on Fetal and Maternal Generation of Thromboxane by Platelets in Women at Risk for Ppregnancy-Induced Hypertension | New England Journal of Medicine | 1989 | 326 |
| 41 | Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 325 |
| 42 | Biochemical and functional characterization of the interaction between pentraxin 3 and C1q | European Journal of Immunology | 2003 | 317 |
| 43 | Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. | Journal of the American Society of Nephrology: JASN | 1995 | 316 |
| 44 | Familial haemolytic uraemic syndrome and an MCP mutation | Lancet, The | 2003 | 303 |
| 45 | Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells | Stem Cells and Development | 2013 | 300 |
| 46 | The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility | Journal of Cell Biology | 2003 | 297 |
| 47 | Insulin-Like Growth Factor-1 Sustains Stem Cell–Mediated Renal Repair | Journal of the American Society of Nephrology: JASN | 2007 | 294 |
| 48 | Guidelines for preclinical animal research in ALS/MND: A consensus meeting | Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders | 2010 | 293 |
| 49 | Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease | Human Molecular Genetics | 2003 | 291 |
| 50 | A literature review on off-label drug use in children | European Journal of Pediatrics | 2005 | 288 |
