| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Identification and expansion of human colon-cancer-initiating cells | Nature | 2007 | 3,690 |
| 3 | In Silico Detection and Typing of Plasmids using PlasmidFinder and Plasmid Multilocus Sequence Typing | Antimicrobial Agents and Chemotherapy | 2014 | 3,558 |
| 4 | Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy | JAMA - Journal of the American Medical Association | 2020 | 3,217 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Cell Death and Differentiation | 2009 | 2,572 |
| 7 | A new variant of Creutzfeldt-Jakob disease in the UK | Lancet, The | 1996 | 2,554 |
| 8 | Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases | PLoS Medicine | 2008 | 2,355 |
| 9 | Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Cell Death and Differentiation | 2012 | 2,144 |
| 10 | Identification of plasmids by PCR-based replicon typing | Journal of Microbiological Methods | 2005 | 2,131 |
| 11 | MicroRNA-133 controls cardiac hypertrophy | Nature Medicine | 2007 | 1,652 |
| 12 | Antimicrobial resistance: a global multifaceted phenomenon | Pathogens and Global Health | 2015 | 1,621 |
| 13 | Liposomes as nanomedical devices | International Journal of Nanomedicine | 2015 | 1,579 |
| 14 | Interaction ruling animal collective behavior depends on topological rather than metric distance: Evidence from a field study | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,557 |
| 15 | Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome | Nature Genetics | 2001 | 1,555 |
| 16 | Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5—a population-based study | Lancet Oncology, The | 2014 | 1,554 |
| 17 | Identification and expansion of the tumorigenic lung cancer stem cell population | Cell Death and Differentiation | 2008 | 1,511 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 19 | QSAR Modeling: Where Have You Been? Where Are You Going To? | Journal of Medicinal Chemistry | 2014 | 1,401 |
| 20 | Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies | BMJ: British Medical Journal | 2005 | 1,284 |
| 21 | Infection with chikungunya virus in Italy: an outbreak in a temperate region | Lancet, The | 2007 | 1,268 |
| 22 | Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells | Nature | 2010 | 1,235 |
| 23 | Flavonoid Intake and Long-term Risk of Coronary Heart Disease and Cancer in the Seven Countries Study | Archives of Internal Medicine | 1995 | 1,215 |
| 24 | Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells | Journal of Biological Chemistry | 2009 | 1,207 |
| 25 | Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 | Journal of Hepatology | 2018 | 1,157 |
| 26 | Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology | Brain | 2006 | 1,142 |
| 27 | Immune function of microglia | Glia | 2001 | 1,126 |
| 28 | Astrocytes are active players in cerebral innate immunity | Trends in Immunology | 2007 | 1,121 |
| 29 | The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics | Cell Biology and Toxicology | 2005 | 1,105 |
| 30 | Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus | Science Translational Medicine | 2011 | 1,080 |
| 31 | Resistance Plasmid Families in Enterobacteriaceae | Antimicrobial Agents and Chemotherapy | 2009 | 1,065 |
| 32 | Cancer survival in five continents: a worldwide population-based study (CONCORD) | Lancet Oncology, The | 2008 | 1,059 |
| 33 | Detection of Ectopic B‐cell Follicles with Germinal Centers in the Meninges of Patients with Secondary Progressive Multiple Sclerosis | Brain Pathology | 2004 | 1,019 |
| 34 | Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia | Nature Genetics | 2003 | 960 |
| 35 | Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo | Immunity | 2001 | 865 |
| 36 | Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential | Journal of Virology | 1998 | 860 |
| 37 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Lancet, The | 2018 | 858 |
| 38 | Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes | Journal of Nutritional Biochemistry | 2005 | 840 |
| 39 | Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy | Nature Medicine | 2014 | 823 |
| 40 | Lymphoid neogenesis in chronic inflammatory diseases | Nature Reviews Immunology | 2006 | 819 |
| 41 | Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data | Lancet Oncology, The | 2007 | 819 |
| 42 | High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients | PLoS ONE | 2009 | 806 |
| 43 | Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use | Research Integrity and Peer Review | 2016 | 801 |
| 44 | Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5—a population-based study | Lancet Oncology, The | 2014 | 799 |
| 45 | THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN | Proceedings of the National Academy of Sciences of the United States of America | 1969 | 787 |
| 46 | Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project | Blood | 2010 | 784 |
| 47 | Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease | Brain | 2009 | 770 |
| 48 | Plasmids and the spread of resistance | International Journal of Medical Microbiology | 2013 | 765 |
| 49 | Antiretroviral Therapy for HIV Infection in 1998 | JAMA - Journal of the American Medical Association | 1998 | 764 |
| 50 | Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance | FEMS Microbiology Reviews | 2017 | 760 |
