| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 3 | Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic Neuropathy | Science | 1988 | 2,292 |
| 4 | Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial | Lancet, The | 2001 | 2,265 |
| 5 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 6 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 7 | Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) | Clinical Neurophysiology | 2014 | 1,647 |
| 8 | Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy | Cell | 2012 | 1,603 |
| 9 | EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals | Endocrine Reviews | 2015 | 1,508 |
| 10 | Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial | Lancet, The | 2008 | 1,442 |
| 11 | Regulation of matrix metalloproteinase expression in tumor invasion | FASEB Journal | 1999 | 1,390 |
| 12 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 13 | Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors | New England Journal of Medicine | 2011 | 1,263 |
| 14 | 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management | European Heart Journal | 2014 | 1,253 |
| 15 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 16 | Morphologic and biochemical hallmarks of apoptosis | Cardiovascular Research | 2000 | 1,116 |
| 17 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 18 | STROCSS 2021: Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery | International Journal of Surgery | 2021 | 938 |
| 19 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 20 | The common cold | Lancet, The | 2003 | 851 |
| 21 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 22 | Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid | Scientific Reports | 2016 | 831 |
| 23 | Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts | PLoS Medicine | 2013 | 753 |
| 24 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 25 | Dexmedetomidine as an Anesthetic Adjunct in Coronary Artery Bypass Grafting | Anesthesiology | 1997 | 746 |
| 26 | Probiotics: an overview of beneficial effects | Antonie Van Leeuwenhoek | 2002 | 737 |
| 27 | Fecal Microflora in Healthy Infants Born by Different Methods of Delivery: Permanent Changes in Intestinal Flora After Cesarean Delivery | Journal of Pediatric Gastroenterology and Nutrition | 1999 | 728 |
| 28 | The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery | International Journal of Surgery | 2017 | 727 |
| 29 | Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial | Lancet, The | 1999 | 725 |
| 30 | Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity | JAMA - Journal of the American Medical Association | 2018 | 711 |
| 31 | Toward defining the autoimmune microbiome for type 1 diabetes | ISME Journal | 2011 | 709 |
| 32 | Genome-wide association analyses identify 18 new loci associated with serum urate concentrations | Nature Genetics | 2013 | 675 |
| 33 | 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study | Lancet Neurology, The | 2010 | 674 |
| 34 | Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes | PLoS ONE | 2011 | 660 |
| 35 | A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844 | International Journal of Radiation Oncology Biology Physics | 1996 | 641 |
| 36 | The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers | Molecular Psychiatry | 1998 | 639 |
| 37 | The human gut microbiome in early-onset type 1 diabetes from the TEDDY study | Nature | 2018 | 623 |
| 38 | Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans | Human Mutation | 2007 | 620 |
| 39 | Revised FIGO staging for carcinoma of the cervix uteri | International Journal of Gynecology and Obstetrics | 2019 | 612 |
| 40 | Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin | Cell Metabolism | 2011 | 609 |
| 41 | Simultaneous quantitative analysis of FcγRI (CD64) expression on neutrophils and monocytes: A new, improved way to detect infections | Journal of Immunological Methods | 2007 | 606 |
| 42 | CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis | Human Immunology | 2009 | 599 |
| 43 | Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab | Annals of Oncology | 2005 | 585 |
| 44 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 45 | Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis | JAMA - Journal of the American Medical Association | 2015 | 577 |
| 46 | Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA | Nature Communications | 2016 | 576 |
| 47 | Etiology of community-acquired pneumonia in 254 hospitalized children | Pediatric Infectious Disease Journal | 2000 | 574 |
| 48 | Psychosocial Risk Factors Associated With Cyberbullying Among Adolescents | Archives of General Psychiatry | 2010 | 561 |
| 49 | Tracking of Physical Activity from Early Childhood through Youth into Adulthood | Medicine and Science in Sports and Exercise | 2014 | 561 |
| 50 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
