| # | Title | Journal | Year | Citations |
|---|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 2 | Peroxynitrite: biochemistry, pathophysiology and development of therapeutics | Nature Reviews Drug Discovery | 2007 | 1,732 |
| 3 | Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index | American Journal of Transplantation | 2006 | 1,624 |
| 4 | Interferons, interferon-like cytokines, and their receptors | Immunological Reviews | 2004 | 1,440 |
| 5 | Obesity, cigarette smoking, and telomere length in women | Lancet, The | 2005 | 1,215 |
| 6 | Community-associated meticillin-resistant Staphylococcus aureus | Lancet, The | 2010 | 1,178 |
| 7 | A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes | Science | 2012 | 1,095 |
| 8 | Aberrant rel/nfkb genes and activity in human cancer | Oncogene | 1999 | 1,051 |
| 9 | Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury | Cancer Letters | 2012 | 1,019 |
| 10 | Interleukin-10andRelatedCytokines andReceptors | Annual Review of Immunology | 2004 | 1,006 |
| 11 | Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 996 |
| 12 | Functional Connectivity of Human Striatum: A Resting State fMRI Study | Cerebral Cortex | 2008 | 962 |
| 13 | MicroRNAs in Development and Disease | Physiological Reviews | 2011 | 959 |
| 14 | Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study | Lancet, The | 2011 | 902 |
| 15 | A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up | Archives of General Psychiatry | 2007 | 863 |
| 16 | Social Cognition in Schizophrenia: An NIMH Workshop on Definitions, Assessment, and Research Opportunities | Schizophrenia Bulletin | 2008 | 818 |
| 17 | Interpreting cDNA sequences: Some insights from studies on translation | Mammalian Genome | 1996 | 784 |
| 18 | Validation of the Edmonton Symptom Assessment Scale | Mammalian Genome | 2000 | 784 |
| 19 | FACT Facilitates Transcription-Dependent Nucleosome Alteration | Science | 2003 | 762 |
| 20 | Accumulation of driver and passenger mutations during tumor progression | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 742 |
| 21 | Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II | Nature | 1994 | 725 |
| 22 | Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease | Immunity | 2004 | 723 |
| 23 | The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L | Molecular and Cellular Biology | 2000 | 717 |
| 24 | MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy | Circulation Research | 2007 | 716 |
| 25 | To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis | Oncogene | 2003 | 704 |
| 26 | Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report | Pediatrics | 2010 | 690 |
| 27 | Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study | American Journal of Epidemiology | 2006 | 686 |
| 28 | Functional connectivity of the human amygdala using resting state fMRI | NeuroImage | 2009 | 680 |
| 29 | Mapping the functional connectivity of anterior cingulate cortex | NeuroImage | 2007 | 678 |
| 30 | Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis | Journal of Immunology | 2009 | 673 |
| 31 | Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II | Nature | 1992 | 665 |
| 32 | Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis | Oncologist | 2010 | 623 |
| 33 | MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation | Circulation Research | 2009 | 613 |
| 34 | Bruxism physiology and pathology: an overview for clinicians* | Journal of Oral Rehabilitation | 2008 | 612 |
| 35 | Household Air Pollution from Coal and Biomass Fuels in China: Measurements, Health Impacts, and Interventions | Environmental Health Perspectives | 2007 | 611 |
| 36 | Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial | Lancet Neurology, The | 2007 | 610 |
| 37 | Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function | Journal of Neuroscience | 1996 | 607 |
| 38 | Virtual reality-enhanced stroke rehabilitation | IEEE Transactions on Neural Systems and Rehabilitation Engineering | 2001 | 602 |
| 39 | Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system | Brain Research | 1988 | 570 |
| 40 | Self-regulation, health, and behavior: A perceptual-cognitive approach | Psychology and Health | 1998 | 565 |
| 41 | Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Nature | 2012 | 560 |
| 42 | Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens | Nature Immunology | 2008 | 558 |
| 43 | Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes | Circulation Research | 2009 | 546 |
| 44 | Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 545 |
| 45 | Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison | Lancet, The | 2005 | 541 |
| 46 | Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women’s Health Initiative Hormone Trial | Diabetologia | 2004 | 524 |
| 47 | A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia | Circulation Research | 2009 | 518 |
| 48 | Core strengthening11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the authors is/are associated. | Archives of Physical Medicine and Rehabilitation | 2004 | 504 |
| 49 | Predictors of smoking cessation in a cohort of adult smokers followed for five years | Tobacco Control | 1997 | 503 |
| 50 | Indentation Damage and Mechanical Properties of Human Enamel and Dentin | Journal of Dental Research | 1998 | 497 |
