| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 3 | Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial | Lancet, The | 2017 | 3,872 |
| 4 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 5 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 6 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 7 | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis | Lancet Oncology, The | 2010 | 1,915 |
| 8 | EGFR Antagonists in Cancer Treatment | New England Journal of Medicine | 2008 | 1,869 |
| 9 | Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome | JAMA - Journal of the American Medical Association | 2004 | 1,819 |
| 10 | Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans | Circulation | 2002 | 1,717 |
| 11 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 12 | Three decades of global methane sources and sinks | Nature Geoscience | 2013 | 1,649 |
| 13 | Oxidative Stress and Diabetic Vascular Complications | Diabetes Care | 1996 | 1,644 |
| 14 | MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,538 |
| 15 | Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders | Journal of Crohn's and Colitis | 2017 | 1,324 |
| 16 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision | Journal of Allergy and Clinical Immunology | 2010 | 1,322 |
| 17 | Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women | JAMA - Journal of the American Medical Association | 2003 | 1,275 |
| 18 | A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients | Hepatology | 1998 | 1,271 |
| 19 | Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial | Lancet, The | 2017 | 1,250 |
| 20 | ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making | Annals of Oncology | 2012 | 1,233 |
| 21 | Silver Nanoparticles as Potential Antibacterial Agents | Molecules | 2015 | 1,212 |
| 22 | Clinical Trials with Mesenchymal Stem Cells: An Update | Cell Transplantation | 2016 | 1,107 |
| 23 | Validating the independent components of neuroimaging time series via clustering and visualization | NeuroImage | 2004 | 1,103 |
| 24 | How mental health care should change as a consequence of the COVID-19 pandemic | Lancet Psychiatry,the | 2020 | 1,101 |
| 25 | Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS | Neuron | 2010 | 1,100 |
| 26 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 27 | Dermoscopy of pigmented skin lesions: Results of a consensus meeting via the Internet | Journal of the American Academy of Dermatology | 2003 | 1,055 |
| 28 | Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial | Lancet, The | 2015 | 1,043 |
| 29 | Process and technological aspects of municipal solid waste gasification. A review | Waste Management | 2012 | 947 |
| 30 | Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year | Circulation | 2002 | 932 |
| 31 | Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer | New England Journal of Medicine | 2019 | 918 |
| 32 | The Effect of Mediterranean Diet on Metabolic Syndrome and its Components | Journal of the American College of Cardiology | 2011 | 917 |
| 33 | Metabolic Syndrome and Risk of Cancer | Diabetes Care | 2012 | 900 |
| 34 | CO2 balance of boreal, temperate, and tropical forests derived from a global database | Global Change Biology | 2007 | 863 |
| 35 | A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD) | European Heart Journal | 2014 | 848 |
| 36 | The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness | Lancet Psychiatry,the | 2019 | 815 |
| 37 | Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 | Cell Death and Differentiation | 2015 | 811 |
| 38 | Chronic inflammation and oxidative stress in human carcinogenesis | International Journal of Cancer | 2007 | 809 |
| 39 | Update of EULAR recommendations for the treatment of systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 794 |
| 40 | Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial | Lancet Oncology, The | 2016 | 778 |
| 41 | Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial | Lancet, The | 2009 | 774 |
| 42 | Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases | European Heart Journal | 2016 | 757 |
| 43 | Changes in sleep pattern, sense of time and digital media use during COVID‐19 lockdown in Italy | Journal of Sleep Research | 2020 | 746 |
| 44 | MiR-15a and miR-16-1 cluster functions in human leukemia | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 741 |
| 45 | Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23 | Science | 1996 | 733 |
| 46 | Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men | JAMA - Journal of the American Medical Association | 2004 | 732 |
| 47 | The promise of retinoids to fight against cancer | Nature Reviews Cancer | 2001 | 712 |
| 48 | Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor | Journal of Experimental Medicine | 2008 | 668 |
| 49 | Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials | Annals of Oncology | 2017 | 654 |
| 50 | Biomass gasification technology: The state of the art overview | Journal of Energy Chemistry | 2016 | 641 |
