| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota | Science | 2015 | 2,539 |
| 3 | High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation | Obesity | 2020 | 1,537 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 5 | Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition | Journal of Pediatric Gastroenterology and Nutrition | 2010 | 1,206 |
| 6 | Mathematical modeling of drug delivery | International Journal of Pharmaceutics | 2008 | 1,036 |
| 7 | Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡ | Human Reproduction | 2018 | 1,015 |
| 8 | Health benefits of fermented foods: microbiota and beyond | Current Opinion in Biotechnology | 2017 | 855 |
| 9 | Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening | Gastroenterology | 2016 | 847 |
| 10 | Complementary Feeding: A Commentary by the ESPGHAN Committee on Nutrition | Journal of Pediatric Gastroenterology and Nutrition | 2008 | 788 |
| 11 | First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2021 | 773 |
| 12 | Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial | Lancet, The | 2016 | 753 |
| 13 | Genomic insights into the origin of farming in the ancient Near East | Nature | 2016 | 733 |
| 14 | Neoliberal Urbanization in Europe: Large-Scale Urban Development Projects and the New Urban Policy | Antipode | 2002 | 714 |
| 15 | Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study | Lancet, The | 2018 | 684 |
| 16 | European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment | Nature Reviews Endocrinology | 2015 | 664 |
| 17 | First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial | Lancet, The | 2021 | 638 |
| 18 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans | Diabetes | 2017 | 615 |
| 19 | EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry | Resuscitation | 2016 | 612 |
| 20 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 21 | Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial | Lancet Neurology, The | 2008 | 531 |
| 22 | Acquired von Willebrand Syndrome After Continuous-Flow Mechanical Device Support Contributes to a High Prevalence of Bleeding During Long-Term Support and at the Time of Transplantation | Journal of the American College of Cardiology | 2010 | 522 |
| 23 | Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial | Lancet, The | 2019 | 517 |
| 24 | The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee | Blood | 2022 | 512 |
| 25 | Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis | Nature Genetics | 2016 | 494 |
| 26 | A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD) | Journal of Thrombosis and Haemostasis | 2006 | 478 |
| 27 | European Integration and Migration Policy: Vertical Policy‐making as Venue Shopping | Journal of Common Market Studies | 2000 | 463 |
| 28 | First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial | Lancet, The | 2017 | 438 |
| 29 | Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study | Resuscitation | 2020 | 428 |
| 30 | Intracerebral haemorrhage: current approaches to acute management | Lancet, The | 2018 | 420 |
| 31 | Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review | Alzheimer's Research and Therapy | 2015 | 419 |
| 32 | Interval Training for Performance: A Scientific and Empirical Practice | Sports Medicine | 2001 | 406 |
| 33 | Delayed sleep phase syndrome response to melatonin | Lancet, The | 1991 | 395 |
| 34 | Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society | Human Reproduction Update | 2014 | 389 |
| 35 | Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke | Neurology | 2002 | 376 |
| 36 | Validity of the Polar S810 Heart Rate Monitor to Measure R-R Intervals at Rest | Medicine and Science in Sports and Exercise | 2006 | 371 |
| 37 | Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations | Chemical Reviews | 2019 | 367 |
| 38 | Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD) | Blood | 2007 | 364 |
| 39 | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Science Immunology | 2021 | 357 |
| 40 | Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial | Lancet Oncology, The | 2017 | 356 |
| 41 | Fine-grained and accurate source code differencing | | 2014 | 344 |
| 42 | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity | Cell Metabolism | 2015 | 342 |
| 43 | Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial | Lancet Oncology, The | 2019 | 342 |
| 44 | Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis | PLoS Medicine | 2017 | 341 |
| 45 | Detection of human adaptation during the past 2000 years | Science | 2016 | 336 |
| 46 | Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders | American Journal of Human Genetics | 2018 | 326 |
| 47 | Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology | Molecular Psychiatry | 2013 | 321 |
| 48 | An Organic Nanoparticle Transistor Behaving as a Biological Spiking Synapse | Advanced Functional Materials | 2010 | 320 |
| 49 | Poststroke dementia | Neurology | 2001 | 318 |
| 50 | Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133) | Journal of Clinical Oncology | 2021 | 317 |
