| # | Title | Journal | Year | Citations |
|---|
| 1 | Artifacts in CT: Recognition and Avoidance | Radiographics | 2004 | 1,378 |
| 2 | Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine | Intensive Care Medicine | 2014 | 1,240 |
| 3 | Guidelines for the management of inflammatory bowel disease in adults | Gut | 2011 | 1,127 |
| 4 | Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial | Lancet, The | 2003 | 1,120 |
| 5 | British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus | Gut | 2014 | 1,116 |
| 6 | Rhythm or rate control in atrial fibrillation—Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial | Lancet, The | 2000 | 1,100 |
| 7 | Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts | Nature Cell Biology | 2013 | 1,088 |
| 8 | 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours | European Journal of Cancer | 2011 | 895 |
| 9 | Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study | Journal of the American College of Cardiology | 2002 | 855 |
| 10 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial | Lancet, The | 2011 | 849 |
| 11 | A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients | JAMA - Journal of the American Medical Association | 1993 | 794 |
| 12 | Transcatheter Aortic Valve Implantation in Failed Bioprosthetic Surgical Valves | JAMA - Journal of the American Medical Association | 2014 | 762 |
| 13 | Lithium dilution cardiac output measurement in the critically ill patient: determination of precision of the technique | Intensive Care Medicine | 2009 | 670 |
| 14 | Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy | Placenta | 1983 | 644 |
| 15 | Peutz-Jeghers syndrome: a systematic review and recommendations for management | Gut | 2010 | 635 |
| 16 | Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445] | Critical Care | 2005 | 632 |
| 17 | Pathophysiology and epidemiology of abdominal aortic aneurysms | Nature Reviews Cardiology | 2011 | 624 |
| 18 | De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes | Nature Genetics | 2012 | 621 |
| 19 | Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study | Annals of Oncology | 2001 | 617 |
| 20 | Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study | Lancet Oncology, The | 2011 | 612 |
| 21 | Chronic Liver Disease--An Increasing Problem: A Study of Hospital Admission and Mortality Rates in England, 1979-2005, with Particular Reference to Alcoholic Liver Disease | Alcohol and Alcoholism | 2008 | 597 |
| 22 | Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine | European Journal of Heart Failure | 2010 | 593 |
| 23 | Guidelines for the clinical management of familial adenomatous polyposis (FAP) | Gut | 2008 | 591 |
| 24 | Procedure‐related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta‐analysis | Ultrasound in Obstetrics and Gynecology | 2015 | 548 |
| 25 | Transdermal oestrogen for treatment of severe postnatal depression | Lancet, The | 1996 | 544 |
| 26 | The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function | Journal of Interferon and Cytokine Research | 1997 | 538 |
| 27 | Identification and characterisation of the high-risk surgical population in the United Kingdom | Critical Care | 2006 | 517 |
| 28 | EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours | European Journal of Cancer | 2006 | 515 |
| 29 | A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures | Nature Genetics | 2008 | 509 |
| 30 | Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit | Anaesthesia | 1999 | 504 |
| 31 | Guidelines for the diagnosis and management of aplastic anaemia | British Journal of Haematology | 2009 | 487 |
| 32 | EAU Guidelines on Penile Cancer: 2014 Update | European Urology | 2015 | 479 |
| 33 | National survey of doses from CT in the UK: 2003 | British Journal of Radiology | 2006 | 476 |
| 34 | Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer) | Journal of Medical Genetics | 2007 | 461 |
| 35 | Mental health-related stigma in health care and mental health-care settings | Lancet Psychiatry,the | 2014 | 461 |
| 36 | Germline mutations in RAD51D confer susceptibility to ovarian cancer | Nature Genetics | 2011 | 460 |
| 37 | ISUOG Practice Guidelines: role of ultrasound in twin pregnancy | Ultrasound in Obstetrics and Gynecology | 2016 | 445 |
| 38 | Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group | British Journal of Dermatology | 2002 | 444 |
| 39 | A Broader Phenotype of Autism: The Clinical Spectrum in Twins | Journal of Child Psychology and Psychiatry and Allied Disciplines | 1996 | 441 |
| 40 | Subtle chromosomal rearrangements in children with unexplained mental retardation | Lancet, The | 1999 | 434 |
| 41 | Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures † †These findings were presented in part at the 13th Annual Meeting of the European Society of Intensive Care Medicine, Rome 2000. | British Journal of Anaesthesia | 2002 | 405 |
| 42 | Perinatal morbidity and mortality in early‐onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE) | Ultrasound in Obstetrics and Gynecology | 2013 | 403 |
| 43 | Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care | Critical Care | 2000 | 400 |
| 44 | Interprofessional collaboration to improve professional practice and healthcare outcomes | The Cochrane Library | 2018 | 396 |
| 45 | The Mechanisms of Action of NSAIDs in Analgesia | Drugs | 1996 | 376 |
| 46 | Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report | Therapeutic Drug Monitoring | 2019 | 374 |
| 47 | The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review | Gut | 2017 | 368 |
| 48 | Cellular senescence in naevi and immortalisation in melanoma: a role for p16? | British Journal of Cancer | 2006 | 364 |
| 49 | Benefits and drawbacks of telemedicine | Journal of Telemedicine and Telecare | 2005 | 352 |
| 50 | Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial | Urology | 2003 | 348 |
