| # | Title | Journal | Year | Citations |
|---|
| 1 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 2 | Frequency of TERT promoter mutations in human cancers | Nature Communications | 2013 | 740 |
| 3 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 4 | Nutritional determinants of frailty in older adults: A systematic review | BMC Geriatrics | 2017 | 363 |
| 5 | Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing | Nature | 2016 | 333 |
| 6 | Obesity, Fat Mass and Immune System: Role for Leptin | Frontiers in Physiology | 2018 | 284 |
| 7 | Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses | Nature Genetics | 2020 | 265 |
| 8 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction | Nature Genetics | 2021 | 264 |
| 9 | What's new in our understanding of the role of adipokines in rheumatic diseases? | Nature Reviews Rheumatology | 2011 | 254 |
| 10 | Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis | Annals of Oncology | 2015 | 191 |
| 11 | The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases | Biomarkers | 2015 | 188 |
| 12 | A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer | Nature Genetics | 2018 | 184 |
| 13 | Genetic insights into biological mechanisms governing human ovarian ageing | Nature | 2021 | 183 |
| 14 | Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients | International Journal of Pharmaceutics | 2019 | 171 |
| 15 | Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity | BioFactors | 2011 | 162 |
| 16 | Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis | Ageing Research Reviews | 2018 | 150 |
| 17 | Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes | Arthritis and Rheumatology | 2015 | 142 |
| 18 | Adipokines, Metabolic Syndrome and Rheumatic Diseases | Journal of Immunology Research | 2014 | 130 |
| 19 | Novel Common Genetic Susceptibility Loci for Colorectal Cancer | Journal of the National Cancer Institute | 2019 | 129 |
| 20 | A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity | Radiotherapy and Oncology | 2014 | 128 |
| 21 | Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes | Nature Genetics | 2020 | 120 |
| 22 | Exosome-mimetic nanoplatforms for targeted cancer drug delivery | Journal of Nanobiotechnology | 2019 | 117 |
| 23 | A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1 | Nature Genetics | 2014 | 114 |
| 24 | Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer | Gastroenterology | 2020 | 110 |
| 25 | Clinical usefulness of gene-expression profile to rule out acute rejection after heart transplantation: CARGO II | European Heart Journal | 2016 | 108 |
| 26 | Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders | Clinical Epigenetics | 2017 | 108 |
| 27 | Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling | ELife | 2015 | 104 |
| 28 | Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk | Nature Genetics | 2012 | 99 |
| 29 | Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients | Radiotherapy and Oncology | 2016 | 98 |
| 30 | Nanoengineering of vaccines using natural polysaccharides | Biotechnology Advances | 2015 | 96 |
| 31 | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease | Arthritis | 2011 | 94 |
| 32 | Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer | Nature Communications | 2019 | 90 |
| 33 | Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer | Molecular Cancer | 2014 | 88 |
| 34 | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants | Nature Communications | 2018 | 88 |
| 35 | Shared heritability and functional enrichment across six solid cancers | Nature Communications | 2019 | 88 |
| 36 | Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells | Oncogene | 2011 | 87 |
| 37 | Analysis of theC9orf72Gene in Patients with Amyotrophic Lateral Sclerosis in Spain and Different Populations Worldwide | Human Mutation | 2013 | 85 |
| 38 | Adiponectin and Leptin Induce VCAM-1 Expression in Human and Murine Chondrocytes | PLoS ONE | 2012 | 84 |
| 39 | Proteomic analysis of the tear film in patients with keratoconus | Molecular Vision | 2010 | 83 |
| 40 | Further evidence for the anti-inflammatory activity of oleocanthal: Inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes | Life Sciences | 2012 | 80 |
| 41 | Cytokines dysregulation in schizophrenia: A systematic review of psychoneuroimmune relationship | Schizophrenia Research | 2018 | 77 |
| 42 | Adiponectin and Leptin: New Targets in Inflammation | Basic and Clinical Pharmacology and Toxicology | 2014 | 74 |
| 43 | Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study | PLoS ONE | 2017 | 72 |
| 44 | Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy | Journal of the National Cancer Institute | 2020 | 71 |
| 45 | Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer | Radiotherapy and Oncology | 2013 | 70 |
| 46 | Cell senescence is an antiviral defense mechanism | Scientific Reports | 2016 | 70 |
| 47 | Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles | Scientific Reports | 2017 | 69 |
| 48 | Analysis of the Factors Determining Survival of Alcoholic Withdrawal Syndrome Patients in a General Hospital | Alcohol and Alcoholism | 2010 | 66 |
| 49 | mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma | Journal of Clinical Endocrinology and Metabolism | 2012 | 66 |
| 50 | Adecuación en España a las recomendaciones terapéuticas de la guía de la ESC sobre insuficiencia cardiaca: ESC Heart Failure Long-term Registry | Revista Espanola De Cardiologia | 2015 | 64 |
