| # | Title | Journal | Year | Citations |
|---|
| 1 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease | Nature | 2001 | 5,088 |
| 2 | Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial | Lancet Oncology, The | 2015 | 2,353 |
| 3 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society | European Heart Journal | 2013 | 2,132 |
| 4 | Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women | JAMA - Journal of the American Medical Association | 2007 | 1,696 |
| 5 | Intrauterine growth curves based on ultrasonically estimated foetal weights | Acta Paediatrica, International Journal of Paediatrics | 1996 | 1,555 |
| 6 | Lipoprotein(a) as a cardiovascular risk factor: current status | European Heart Journal | 2010 | 1,392 |
| 7 | Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed | Journal of Clinical Epidemiology | 2011 | 1,362 |
| 8 | Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure | New England Journal of Medicine | 2016 | 1,350 |
| 9 | Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2014 | 1,280 |
| 10 | Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial | Lancet, The | 2008 | 1,248 |
| 11 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 2020 | 1,209 |
| 12 | A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer | New England Journal of Medicine | 2015 | 1,084 |
| 13 | Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management | European Heart Journal | 2015 | 1,024 |
| 14 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial | Lancet Oncology, The | 2013 | 998 |
| 15 | Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management | European Heart Journal | 2011 | 993 |
| 16 | Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction | JAMA - Journal of the American Medical Association | 2009 | 977 |
| 17 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 18 | Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease | Nature Genetics | 2014 | 938 |
| 19 | The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications | Ultraschall in Der Medizin | 2012 | 922 |
| 20 | Mapping of a susceptibility locus for Crohn's disease on chromosome 16 | Nature | 1996 | 906 |
| 21 | Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial | Lancet, The | 2009 | 886 |
| 22 | Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1? generation | Clinical and Experimental Immunology | 2006 | 832 |
| 23 | Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial | Lancet Oncology, The | 2014 | 823 |
| 24 | Statin Use and Reduced Cancer-Related Mortality | New England Journal of Medicine | 2012 | 798 |
| 25 | Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes | Diabetes Care | 2015 | 791 |
| 26 | The burden of inflammatory bowel disease in Europe | Journal of Crohn's and Colitis | 2013 | 781 |
| 27 | Industry sponsorship and research outcome | The Cochrane Library | 2017 | 772 |
| 28 | A Qualitative and Quantitative Systematic Review of Preemptive Analgesia for Postoperative Pain Relief | Anesthesiology | 2002 | 757 |
| 29 | Loss-of-Function Mutations inAPOC3and Risk of Ischemic Vascular Disease | New England Journal of Medicine | 2014 | 749 |
| 30 | Diagnostic Criteria, Classification, and Nomenclature for Painful Bladder Syndrome/Interstitial Cystitis: An ESSIC Proposal | European Urology | 2008 | 747 |
| 31 | Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma | Journal of Developmental and Physical Disabilities | 1987 | 720 |
| 32 | Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease | New England Journal of Medicine | 2008 | 714 |
| 33 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012 | Ultrasound in Medicine and Biology | 2013 | 652 |
| 34 | Course of ulcerative colitis: Analysis of changes in disease activity over years | Gastroenterology | 1994 | 638 |
| 35 | Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial | Lancet, The | 2003 | 626 |
| 36 | Nurse involvement in end-of-life decision making: the ETHICUS Study | Intensive Care Medicine | 2006 | 624 |
| 37 | Familial Occurrence of Inflammatory Bowel Disease | New England Journal of Medicine | 1991 | 605 |
| 38 | A common coding variant in CASP8 is associated with breast cancer risk | Nature Genetics | 2007 | 591 |
| 39 | Frequency of glucocorticoid resistance and dependency in Crohn's disease. | Gut | 1994 | 587 |
| 40 | A Randomized, Placebo-Controlled Trial of Certolizumab Pegol (CDP870) for Treatment of Crohn’s Disease | Gastroenterology | 2005 | 571 |
| 41 | Guidelines for laparoscopic (TAPP) and endoscopic (TEP) treatment of inguinal Hernia [International Endohernia Society (IEHS)] | Surgical Endoscopy and Other Interventional Techniques | 2011 | 561 |
| 42 | Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed | International Journal of Nursing Studies | 2011 | 552 |
| 43 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 548 |
| 44 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 528 |
| 45 | A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85 | Radiotherapy and Oncology | 1998 | 523 |
| 46 | Familial Hypercholesterolemia in the Danish General Population: Prevalence, Coronary Artery Disease, and Cholesterol-Lowering Medication | Journal of Clinical Endocrinology and Metabolism | 2012 | 523 |
| 47 | A Clinical Grading Scale to Predict Malignant Hyperthermia Susceptibility | Anesthesiology | 1994 | 520 |
| 48 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 49 | Increased Risk of Intestinal Cancer in Crohn's Disease: A Meta-Analysis of Population-Based Cohort Studies | American Journal of Gastroenterology | 2005 | 500 |
| 50 | Development of the Crohnʼs disease digestive damage score, the Lémann score | Inflammatory Bowel Diseases | 2011 | 496 |
