| # | Title | Journal | Year | Citations |
|---|
| 1 | Some new, simple and efficient stereological methods and their use in pathological research and diagnosis | Apmis | 1988 | 2,680 |
| 2 | Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease | Gastroenterology | 2015 | 2,200 |
| 3 | Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients | Arthritis and Rheumatism | 2002 | 1,736 |
| 4 | Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure | New England Journal of Medicine | 2016 | 1,350 |
| 5 | Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study | Lancet, The | 2002 | 1,207 |
| 6 | Changing patterns of mortality across Europe in patients infected with HIV-1 | Lancet, The | 1998 | 1,182 |
| 7 | Decline in the AIDS and death rates in the EuroSIDA study: an observational study | Lancet, The | 2003 | 1,157 |
| 8 | Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial | Lancet, The | 2003 | 1,120 |
| 9 | Randomized clinical trial of virtual reality simulation for laparoscopic skills training | British Journal of Surgery | 2004 | 1,045 |
| 10 | Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer | Gut | 2017 | 865 |
| 11 | Changes in Forced Expiratory Volume in 1 Second over Time in COPD | New England Journal of Medicine | 2011 | 811 |
| 12 | Direct detection of early-stage cancers using circulating tumor DNA | Science Translational Medicine | 2017 | 808 |
| 13 | Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients | Diabetes | 2001 | 796 |
| 14 | BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS | Lancet, The | 1989 | 795 |
| 15 | Effect of sibutramine on weight maintenance after weight loss: a randomised trial | Lancet, The | 2000 | 790 |
| 16 | Determinants of the Impaired Secretion of Glucagon-Like Peptide-1 in Type 2 Diabetic Patients | Journal of Clinical Endocrinology and Metabolism | 2001 | 767 |
| 17 | Genome-wide cell-free DNA fragmentation in patients with cancer | Nature | 2019 | 764 |
| 18 | Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial | Lancet, The | 1999 | 756 |
| 19 | Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma | Journal of Developmental and Physical Disabilities | 1987 | 720 |
| 20 | EASE: Examination of Anomalous Self-Experience | Psychopathology | 2005 | 663 |
| 21 | suPAR: The Molecular Crystal Ball | Disease Markers | 2009 | 657 |
| 22 | Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) | European Respiratory Journal | 2008 | 591 |
| 23 | Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial | BMJ, The | 2012 | 555 |
| 24 | Mortality associated with moderate intakes of wine, beer, or spirits | BMJ: British Medical Journal | 1995 | 546 |
| 25 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers | Clinical Chemistry | 2008 | 539 |
| 26 | Randomised trial of endoscopic endoprosthesis versus operative bypass in malignant obstructive jaundice. | Gut | 1989 | 532 |
| 27 | Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics | Archives of General Psychiatry | 1990 | 517 |
| 28 | The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on -Cell Sensitivity in Type 2 and Nondiabetic Subjects | Diabetes | 2003 | 513 |
| 29 | Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon | Gastroenterology | 2001 | 490 |
| 30 | In vivo relaxation of N-acetyl-aspartate, creatine plus phosphocreatine, and choline containing compounds during the course of brain infarction: A proton MRS study | Magnetic Resonance Imaging | 1992 | 473 |
| 31 | Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods | International Journal of Antimicrobial Agents | 2012 | 473 |
| 32 | Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort | Aids | 2005 | 472 |
| 33 | European Hernia Society guidelines on the closure of abdominal wall incisions | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2015 | 460 |
| 34 | Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients | Diabetologia | 2002 | 449 |
| 35 | Increasing Incidences of Inflammatory Bowel Disease and Decreasing Surgery Rates in Copenhagen City and County, 2003–2005: A Population-Based Study from the Danish Crohn Colitis Database | American Journal of Gastroenterology | 2006 | 446 |
| 36 | Interleukin-6 and Diabetes: The Good, the Bad, or the Indifferent? | Diabetes | 2005 | 442 |
| 37 | Incretin Secretion in Relation to Meal Size and Body Weight in Healthy Subjects and People with Type 1 and Type 2 Diabetes Mellitus | Journal of Clinical Endocrinology and Metabolism | 2003 | 440 |
| 38 | Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans | Cell Metabolism | 2016 | 435 |
| 39 | AIDS across Europe, 1994–98: the EuroSIDA study | Lancet, The | 2000 | 431 |
| 40 | Long term prognosis of fatty liver: risk of chronic liver disease and death | Gut | 2004 | 430 |
| 41 | Familial adenomatous polyposis (FAP): Frequency, penetrance, and mutation rate | Human Mutation | 1994 | 425 |
| 42 | Rapid Whole-Genome Sequencing for Detection and Characterization of Microorganisms Directly from Clinical Samples | Journal of Clinical Microbiology | 2014 | 424 |
| 43 | Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes | Diabetes Care | 2007 | 415 |
| 44 | Individualised therapy is more cost-effective than dose intensification in patients with Crohn’s disease who lose response to anti-TNF treatment: a randomised, controlled trial | Gut | 2014 | 413 |
| 45 | A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic | Genome Research | 2013 | 412 |
| 46 | Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors | Magnetic Resonance in Medicine | 1990 | 399 |
| 47 | A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy | Epilepsy Research | 1989 | 386 |
| 48 | Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: A randomized, double-blind trial | Gastroenterology | 2004 | 386 |
| 49 | Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery | Gut | 2016 | 381 |
| 50 | Characteristics and prediction of early pain after laparoscopic cholecystectomy | Pain | 2001 | 375 |
