| # | Title | Journal | Year | Citations |
|---|
| 1 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China | Lancet, The | 2020 | 36,800 |
| 2 | Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study | Lancet, The | 2020 | 21,698 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury | Nature Medicine | 2005 | 2,986 |
| 6 | Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial | Lancet, The | 2020 | 2,875 |
| 7 | Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV | Nature Communications | 2020 | 2,617 |
| 8 | ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility | Molecular Cell | 2013 | 2,549 |
| 9 | Angiotensin-converting enzyme 2 protects from severe acute lung failure | Nature | 2005 | 2,264 |
| 10 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 11 | Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China | Cell Host and Microbe | 2020 | 1,860 |
| 12 | Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide | Cell Stem Cell | 2008 | 1,766 |
| 13 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010 | Lancet, The | 2013 | 1,627 |
| 14 | Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus | ELife | 2012 | 1,621 |
| 15 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury | Science China Life Sciences | 2020 | 1,606 |
| 16 | ESPEN guidelines on definitions and terminology of clinical nutrition | Clinical Nutrition | 2017 | 1,451 |
| 17 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 18 | Cancer statistics in China and United States, 2022: profiles, trends, and determinants | Chinese Medical Journal | 2022 | 1,385 |
| 19 | Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack | New England Journal of Medicine | 2013 | 1,384 |
| 20 | Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) | Clinical Infectious Diseases | 2020 | 1,334 |
| 21 | Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020 | Chinese Medical Journal | 2021 | 1,329 |
| 22 | The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment | Nature Medicine | 2015 | 1,306 |
| 23 | Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study | Lancet, The | 2015 | 1,295 |
| 24 | VFDB 2019: a comparative pathogenomic platform with an interactive web interface | Nucleic Acids Research | 2019 | 1,286 |
| 25 | On the origin and continuing evolution of SARS-CoV-2 | National Science Review | 2020 | 1,248 |
| 26 | Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins | Nature Medicine | 2004 | 1,200 |
| 27 | VFDB 2016: hierarchical and refined dataset for big data analysis—10 years on | Nucleic Acids Research | 2016 | 1,188 |
| 28 | Breast cancer in China | Lancet Oncology, The | 2014 | 1,168 |
| 29 | Validation of the ITS2 Region as a Novel DNA Barcode for Identifying Medicinal Plant Species | PLoS ONE | 2010 | 1,152 |
| 30 | Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials | Lancet, The | 2000 | 1,136 |
| 31 | American College of Rheumatology classification criteria for Sjögren's syndrome: A data‐driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance Cohort | Arthritis Care and Research | 2012 | 1,127 |
| 32 | Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2016 | 1,121 |
| 33 | Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults | Biomedical and Environmental Sciences | 2002 | 1,114 |
| 34 | Gut microbiota dysbiosis contributes to the development of hypertension | Microbiome | 2017 | 1,086 |
| 35 | Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,061 |
| 36 | The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus | Nature | 2011 | 1,050 |
| 37 | ceRNA in cancer: possible functions and clinical implications | Journal of Medical Genetics | 2015 | 1,031 |
| 38 | The gut microbiome in atherosclerotic cardiovascular disease | Nature Communications | 2017 | 1,029 |
| 39 | Epidemiology of Esophageal Squamous Cell Carcinoma | Gastroenterology | 2018 | 1,014 |
| 40 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 41 | The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice | Nature | 2020 | 992 |
| 42 | The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation | Science | 2014 | 967 |
| 43 | Human metabolic phenotype diversity and its association with diet and blood pressure | Nature | 2008 | 966 |
| 44 | Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response | Journal of Virology | 2011 | 963 |
| 45 | Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors | Lancet Neurology, The | 2008 | 960 |
| 46 | Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial | Lancet Oncology, The | 2016 | 950 |
| 47 | Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study | Lancet, The | 2018 | 938 |
| 48 | Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study | Lancet, The | 2020 | 935 |
| 49 | KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation | Science | 2003 | 928 |
| 50 | Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study | Chinese Medical Journal | 2020 | 928 |
