| # | Title | Journal | Year | Citations |
|---|
| 1 | Autophagy fights disease through cellular self-digestion | Nature | 2008 | 5,714 |
| 2 | Autophagy: Renovation of Cells and Tissues | Cell | 2011 | 4,844 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Methods in Mammalian Autophagy Research | Cell | 2010 | 3,939 |
| 5 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 6 | Autophagy: process and function | Genes and Development | 2007 | 3,312 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 8 | Autophagy in immunity and inflammation | Nature | 2011 | 2,901 |
| 9 | The Role of Atg Proteins in Autophagosome Formation | Annual Review of Cell and Developmental Biology | 2011 | 2,587 |
| 10 | Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways | Science | 1997 | 2,209 |
| 11 | How to Interpret LC3 Immunoblotting | Autophagy | 2007 | 2,207 |
| 12 | Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C | Nature Genetics | 2009 | 2,124 |
| 13 | A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice | Gastroenterology | 1990 | 2,091 |
| 14 | Partitioning heritability by functional annotation using genome-wide association summary statistics | Nature Genetics | 2015 | 2,045 |
| 15 | Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy | Molecular Biology of the Cell | 2009 | 1,743 |
| 16 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems | Nature Reviews Immunology | 2007 | 1,674 |
| 17 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression | Nature Medicine | 2011 | 1,593 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 19 | Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors | Cell | 2002 | 1,391 |
| 20 | A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells | Nature | 2008 | 1,341 |
| 21 | Myopia | Lancet, The | 2012 | 1,334 |
| 22 | Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction | Journal of Experimental Medicine | 2006 | 1,320 |
| 23 | Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source | Arthritis and Rheumatism | 2005 | 1,314 |
| 24 | Autophagy in mammalian development and differentiation | Nature Cell Biology | 2010 | 1,313 |
| 25 | Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome | Science | 2000 | 1,293 |
| 26 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 27 | The general rules for the gastric cancer study in surgery and pathology | The Japanese Journal of Surgery | 1981 | 1,202 |
| 28 | ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Genes and Development | 2002 | 1,200 |
| 29 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 30 | The molecular understanding of osteoclast differentiation | Bone | 2007 | 1,177 |
| 31 | MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions | Nature | 1999 | 1,161 |
| 32 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 33 | Leptin regulation of bone resorption by the sympathetic nervous system and CART | Nature | 2005 | 1,105 |
| 34 | ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis | EMBO Reports | 2001 | 1,103 |
| 35 | Autophagy-deficient mice develop multiple liver tumors | Genes and Development | 2011 | 1,094 |
| 36 | Neurotransmitter functions of mammalian tachykinins. | Physiological Reviews | 1993 | 1,091 |
| 37 | Tools for the body (schema) | Trends in Cognitive Sciences | 2004 | 1,075 |
| 38 | The promotion of adhesion by the infiltration of monomers into tooth substrates | Journal of Biomedical Materials Research Part B | 1982 | 1,063 |
| 39 | Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells | Nature | 1996 | 1,059 |
| 40 | The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes | Cell | 2012 | 1,042 |
| 41 | Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2 | Journal of Experimental Medicine | 2001 | 1,025 |
| 42 | Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG | Molecular Biology of the Cell | 2008 | 1,025 |
| 43 | Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection | New England Journal of Medicine | 1996 | 995 |
| 44 | Cloning and expression of apical membrane water channel of rat kidney collecting tubule | Nature | 1993 | 978 |
| 45 | RANKL–RANK signaling in osteoclastogenesis and bone disease | Trends in Molecular Medicine | 2006 | 970 |
| 46 | Dental caries | Nature Reviews Disease Primers | 2017 | 958 |
| 47 | Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer | Cell | 2002 | 957 |
| 48 | Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning | Journal of Immunological Methods | 2008 | 953 |
| 49 | BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M | Molecular and Cellular Biology | 1999 | 951 |
| 50 | Discovery of Atg5/Atg7-independent alternative macroautophagy | Nature | 2009 | 949 |
