| # | Title | Journal | Year | Citations |
|---|
| 1 | Ubiquitin is phosphorylated by PINK1 to activate parkin | Nature | 2014 | 1,185 |
| 2 | Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome | Pain | 2007 | 944 |
| 3 | IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases | Nature | 2014 | 882 |
| 4 | Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results | Annals of Neurology | 1995 | 758 |
| 5 | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases | Neuron | 2017 | 730 |
| 6 | High‐frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery | Annals of Neurology | 2010 | 645 |
| 7 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 8 | Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control | EMBO Journal | 2014 | 546 |
| 9 | Interictal high‐frequency oscillations (80–500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain | Epilepsia | 2008 | 542 |
| 10 | Interhemispheric Anatomical Differences in Human Primary Auditory Cortex: Probabilistic Mapping and Volume Measurement from Magnetic Resonance Scans | Cerebral Cortex | 1996 | 534 |
| 11 | B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells | Journal of Experimental Medicine | 2012 | 530 |
| 12 | Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy | Nature Medicine | 1996 | 522 |
| 13 | High-frequency oscillations during human focal seizures | Brain | 2006 | 486 |
| 14 | Intraoperative brain cancer detection with Raman spectroscopy in humans | Science Translational Medicine | 2015 | 457 |
| 15 | Reversible decreases inN-acetylaspartate after acute brain injury | Magnetic Resonance in Medicine | 1995 | 453 |
| 16 | Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair | ACS Nano | 2014 | 449 |
| 17 | Axonal damage correlates with disability in patients with relapsing- remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study | Brain | 1998 | 448 |
| 18 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 19 | Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease | Trends in Biochemical Sciences | 2015 | 444 |
| 20 | Focal neuronal migration disorders and intractable partial epilepsy: A study of 30 patients | Annals of Neurology | 1991 | 443 |
| 21 | Canadian stroke best practice recommendations: Stroke rehabilitation practice guidelines, update 2015 | International Journal of Stroke | 2016 | 440 |
| 22 | Abnormal B‐cell cytokine responses a trigger of T‐cell–mediated disease in MS? | Annals of Neurology | 2010 | 428 |
| 23 | Graph-Theoretical Analysis Reveals Disrupted Small-World Organization of Cortical Thickness Correlation Networks in Temporal Lobe Epilepsy | Cerebral Cortex | 2011 | 396 |
| 24 | First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma | Journal of Translational Medicine | 2018 | 376 |
| 25 | Clinical Phenotypes of Different MPZ (P0) Mutations May Include Charcot–Marie–Tooth Type 1B, Dejerine–Sottas, and Congenital Hypomyelination | Neuron | 1996 | 372 |
| 26 | High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type | Brain | 2009 | 367 |
| 27 | Interictal high-frequency oscillations (100–500 Hz) in the intracerebral EEG of epileptic patients | Brain | 2007 | 363 |
| 28 | Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype | JCI Insight | 2016 | 356 |
| 29 | Hippocampal sclerosis in temporal lobe epilepsy demonstrated by magnetic resonance imaging | Annals of Neurology | 1991 | 354 |
| 30 | Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study | Brain | 2018 | 352 |
| 31 | Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology | Brain | 2014 | 350 |
| 32 | Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations With the Cortisol Response to Awakening | Psychosomatic Medicine | 2003 | 346 |
| 33 | Mitochondrial ATP synthase subunitc storage in the ceroid-lipofuscinoses (Batten disease) | American Journal of Medical Genetics Part A | 1992 | 334 |
| 34 | Microstructural and functional gradients are increasingly dissociated in transmodal cortices | PLoS Biology | 2019 | 332 |
| 35 | Focal neuronal migration disorders and intractable partial epilepsy: Results of surgical treatment | Annals of Neurology | 1991 | 331 |
| 36 | Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations | Brain | 2015 | 326 |
| 37 | Atypical functional connectome hierarchy in autism | Nature Communications | 2019 | 326 |
| 38 | Roles of microglia in brain development, tissue maintenance and repair | Brain | 2015 | 316 |
| 39 | Fronto-striatal connections in the human brain: A probabilistic diffusion tractography study | Neuroscience Letters | 2007 | 313 |
| 40 | Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques | Annals of Neurology | 1992 | 311 |
| 41 | Hemispherectomy for Seizures Revisited | Canadian Journal of Neurological Sciences | 1983 | 308 |
| 42 | Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study | Lancet, The | 2016 | 306 |
| 43 | Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy | Nature Communications | 2020 | 300 |
| 44 | Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial | Lancet, The | 2016 | 296 |
| 45 | Pitch perception of complex tones and human temporal‐lobe function | Journal of the Acoustical Society of America | 1988 | 295 |
| 46 | Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes | NeuroImage | 2016 | 290 |
| 47 | Chemical pathology of acute demyelinating lesions and its correlation with disability | Annals of Neurology | 1995 | 288 |
| 48 | Olfactory identification deficits in patients with focal cerebral excision | Neuropsychologia | 1988 | 287 |
| 49 | BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets | Communications Biology | 2020 | 285 |
| 50 | MAFG-driven astrocytes promote CNS inflammation | Nature | 2020 | 282 |
