| # | Title | Journal | Year | Citations |
|---|
| 1 | Mutations in PCSK9 cause autosomal dominant hypercholesterolemia | Nature Genetics | 2003 | 2,532 |
| 2 | Apolipoprotein E polymorphism and atherosclerosis. | Arteriosclerosis (Dallas, Tex ) | 1988 | 1,773 |
| 3 | Role of Endothelial Dysfunction in Atherosclerosis | Circulation | 2004 | 1,757 |
| 4 | Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency | Nature Genetics | 1999 | 1,609 |
| 5 | Chloroquine is a potent inhibitor of SARS coronavirus infection and spread | Virology Journal | 2005 | 1,457 |
| 6 | Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells | Nature | 2003 | 1,371 |
| 7 | Apolipoprotein E polymorphism and Alzheimer's disease | Lancet, The | 1993 | 1,216 |
| 8 | The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,012 |
| 9 | Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1 | Brain Research | 1999 | 775 |
| 10 | Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension | Hypertension | 2004 | 763 |
| 11 | Beneficial Cardiovascular Pleiotropic Effects of Statins | Circulation | 2004 | 697 |
| 12 | Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury | Journal of Biological Chemistry | 2004 | 680 |
| 13 | The biology and therapeutic targeting of the proprotein convertases | Nature Reviews Drug Discovery | 2012 | 647 |
| 14 | Complete protein sequence and identification of structural domains of human apolipoprotein B | Nature | 1986 | 625 |
| 15 | FSH Directly Regulates Bone Mass | Cell | 2006 | 612 |
| 16 | PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 586 |
| 17 | Correction of Arterial Structure and Endothelial Dysfunction in Human Essential Hypertension by the Angiotensin Receptor Antagonist Losartan | Circulation | 2000 | 584 |
| 18 | Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure | Immunity | 2013 | 571 |
| 19 | Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b | EMBO Journal | 1998 | 563 |
| 20 | Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries | Circulation Research | 2002 | 558 |
| 21 | Statins UpregulatePCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia | Arteriosclerosis, Thrombosis, and Vascular Biology | 2004 | 557 |
| 22 | Reactive oxygen species in vascular biology: implications in hypertension | Histochemistry and Cell Biology | 2004 | 553 |
| 23 | Endothelial function and dysfunction. Part I | Journal of Hypertension | 2005 | 553 |
| 24 | NARC-1/PCSK9 and Its Natural Mutants | Journal of Biological Chemistry | 2004 | 544 |
| 25 | The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury | Journal of Neuroscience | 1992 | 537 |
| 26 | cDNA Sequence of Two Distinct Pituitary Proteins Homologous to Kex2 and Furin Gene Products: Tissue-Specific mRNAs Encoding Candidates for Pro-Hormone Processing Proteinases | DNA and Cell Biology | 1990 | 529 |
| 27 | Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2 | Molecular Endocrinology | 1991 | 502 |
| 28 | Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins | Nature | 1989 | 476 |
| 29 | Nef Harbors a Major Determinant of Pathogenicity for an AIDS-like Disease Induced by HIV-1 in Transgenic Mice | Cell | 1998 | 444 |
| 30 | The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions | Biochimie | 1994 | 417 |
| 31 | Structure and Mechanical Properties of Resistance Arteries in Hypertension | Hypertension | 2000 | 403 |
| 32 | The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2 | Journal of Biological Chemistry | 2008 | 402 |
| 33 | Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. | Journal of Lipid Research | 1992 | 383 |
| 34 | Spironolactone Improves Angiotensin-Induced Vascular Changes and Oxidative Stress | Hypertension | 2002 | 373 |
| 35 | Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration | Hepatology | 2008 | 354 |
| 36 | Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux | Lancet, The | 1999 | 345 |
| 37 | Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2 | Nature | 2005 | 344 |
| 38 | Overexpression of the myeloid leukemia–associatedHoxa9 gene in bone marrow cells induces stem cell expansion | Blood | 2002 | 317 |
| 39 | Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases | FEBS Letters | 1996 | 309 |
| 40 | Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis | Journal of Lipid Research | 1992 | 304 |
| 41 | Severe immunodeficiency disease induced by a defective murine leukaemia virus | Nature | 1989 | 299 |
| 42 | Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons | Journal of Neuroscience | 1999 | 299 |
| 43 | Endothelium-Restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction | Circulation | 2004 | 296 |
| 44 | Reduced Vascular Remodeling, Endothelial Dysfunction, and Oxidative Stress in Resistance Arteries of Angiotensin II–Infused Macrophage Colony-Stimulating Factor–Deficient Mice | Arteriosclerosis, Thrombosis, and Vascular Biology | 2005 | 293 |
| 45 | The activation and physiological functions of the proprotein convertases | International Journal of Biochemistry and Cell Biology | 2008 | 285 |
| 46 | In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein | Nature Medicine | 2003 | 282 |
| 47 | Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill-withdrawal reflex ofAplysia | Journal of Neurobiology | 1989 | 280 |
| 48 | Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 273 |
| 49 | Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding | Journal of Biological Chemistry | 2001 | 273 |
| 50 | Reactive oxygen species and angiotensin II signaling in vascular cells: implications in cardiovascular disease | Brazilian Journal of Medical and Biological Research | 2004 | 272 |
