| # | Title | Journal | Year | Citations |
|---|
| 1 | The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic | Nature Reviews Gastroenterology and Hepatology | 2014 | 5,773 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 4 | Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 3,581 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota | Science | 2015 | 2,539 |
| 7 | A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction | Nature | 1998 | 2,112 |
| 8 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 9 | Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism | Circulation | 1998 | 1,540 |
| 10 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 12 | HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events | New England Journal of Medicine | 2007 | 1,390 |
| 13 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 14 | Defeating Alzheimer's disease and other dementias: a priority for European science and society | Lancet Neurology, The | 2016 | 1,242 |
| 15 | Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) | Nature | 1996 | 1,240 |
| 16 | Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis | Journal of Clinical Microbiology | 2006 | 1,181 |
| 17 | PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties | Cell Metabolism | 2007 | 1,125 |
| 18 | Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein | Viruses | 2012 | 1,086 |
| 19 | Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression | Journal of Lipid Research | 1996 | 1,070 |
| 20 | Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes | Journal of Experimental Medicine | 2003 | 1,008 |
| 21 | Compilation of vertebrate-encoded transcription factors | Nucleic Acids Research | 1992 | 1,007 |
| 22 | Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1 | Journal of Biological Chemistry | 1999 | 982 |
| 23 | A frameshift mutation in human MC4R is associated with a dominant form of obesity | Nature Genetics | 1998 | 975 |
| 24 | Pulmonary Embolism in Patients With COVID-19 | Circulation | 2020 | 961 |
| 25 | The genome of the blood fluke Schistosoma mansoni | Nature | 2009 | 945 |
| 26 | Fruit and Vegetable Consumption and Risk of Coronary Heart Disease: A Meta-Analysis of Cohort Studies | Journal of Nutrition | 2006 | 933 |
| 27 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Lancet, The | 2018 | 858 |
| 28 | Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation | Inflammation Research | 2000 | 853 |
| 29 | Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening | Gastroenterology | 2016 | 847 |
| 30 | Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression | Journal of Lipid Research | 1996 | 837 |
| 31 | Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors | Immunity | 2016 | 797 |
| 32 | Sorting out the roles of PPAR in energy metabolism and vascular homeostasis | Journal of Clinical Investigation | 2006 | 779 |
| 33 | EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries | European Journal of Preventive Cardiology | 2016 | 772 |
| 34 | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance | Nature Genetics | 2012 | 762 |
| 35 | Genomic insights into the origin of farming in the ancient Near East | Nature | 2016 | 733 |
| 36 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 37 | Peroxisome proliferator-activated receptors in inflammation control | Journal of Endocrinology | 2001 | 697 |
| 38 | Expression of the peroxisome proliferator-activated receptor (PPAR ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 680 |
| 39 | Genome-wide association analyses identify 18 new loci associated with serum urate concentrations | Nature Genetics | 2013 | 675 |
| 40 | Association of Cardiometabolic Multimorbidity With Mortality | JAMA - Journal of the American Medical Association | 2015 | 624 |
| 41 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans | Diabetes | 2017 | 615 |
| 42 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 43 | In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma | Journal of Experimental Medicine | 2005 | 573 |
| 44 | Automated High-Throughput Genotyping for Study of Global Epidemiology of Mycobacterium tuberculosis Based on Mycobacterial Interspersed Repetitive Units | Journal of Clinical Microbiology | 2001 | 559 |
| 45 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 46 | The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation | Nature | 1990 | 530 |
| 47 | Worldwide Occurrence of Beijing/W Strains ofMycobacterium tuberculosis: A Systematic Review | Emerging Infectious Diseases | 2002 | 529 |
| 48 | Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor | Journal of Biological Chemistry | 2003 | 525 |
| 49 | PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD | Nature Reviews Endocrinology | 2017 | 509 |
| 50 | Macrophage subsets in atherosclerosis | Nature Reviews Cardiology | 2015 | 501 |
