| # | Title | Journal | Year | Citations |
|---|
| 1 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 2 | Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase | Diabetes | 2006 | 411 |
| 3 | Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges | Immunity | 2011 | 276 |
| 4 | Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure* | Critical Care Medicine | 2005 | 256 |
| 5 | Key clinical features to identify girls with CDKL5 mutations | Brain | 2008 | 242 |
| 6 | Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men | European Journal of Human Genetics | 2010 | 226 |
| 7 | HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy | Nature Microbiology | 2019 | 226 |
| 8 | Corticotroph Tumor Progression after Adrenalectomy in Cushing’s Disease: A Reappraisal of Nelson’s Syndrome | Journal of Clinical Endocrinology and Metabolism | 2007 | 221 |
| 9 | Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors | Science Immunology | 2018 | 171 |
| 10 | Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans | American Journal of Clinical Nutrition | 2017 | 168 |
| 11 | Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial | Intensive Care Medicine | 2003 | 166 |
| 12 | Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans–T cell conjugates | Mucosal Immunology | 2010 | 138 |
| 13 | β-Catenin Activation Is Associated with Specific Clinical and Pathologic Characteristics and a Poor Outcome in Adrenocortical Carcinoma | Clinical Cancer Research | 2011 | 128 |
| 14 | Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis | Critical Care Medicine | 2004 | 119 |
| 15 | FOXL2 and SOX9 as parameters of female and male gonadal differentiation in patients with various forms of disorders of sex development (DSD) | Journal of Pathology | 2008 | 115 |
| 16 | Isotype modulates epitope specificity, affinity, and antiviral activities of anti–HIV-1 human broadly neutralizing 2F5 antibody | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 115 |
| 17 | Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo | Hepatology | 2002 | 109 |
| 18 | Recent insights on the genetics and epigenetics of endometriosis | Clinical Genetics | 2017 | 106 |
| 19 | Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice | Mechanisms of Development | 2009 | 102 |
| 20 | Performance of Candidate Serum Biomarkers for Systemic Sclerosis–Associated Interstitial Lung Disease | Arthritis and Rheumatology | 2019 | 101 |
| 21 | Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2 + Human Pancreatic Progenitors | Cell Reports | 2017 | 100 |
| 22 | The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): Role, methodology, and results* | Critical Care Medicine | 2003 | 97 |
| 23 | Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle | Journal of Cell Biology | 2003 | 94 |
| 24 | Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy | Human Molecular Genetics | 2003 | 91 |
| 25 | HIV-1 Vpr—a still “enigmatic multitasker†| Frontiers in Microbiology | 2014 | 88 |
| 26 | Transcriptional programs that control expression of the autoimmune regulator gene Aire | Nature Immunology | 2017 | 81 |
| 27 | The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells | Journal of Neural Transmission | 2014 | 80 |
| 28 | Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling | Development (Cambridge) | 2018 | 78 |
| 29 | Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 77 |
| 30 | HIV-1 Efficient Entry in Inner Foreskin Is Mediated by Elevated CCL5/RANTES that Recruits T Cells and Fuels Conjugate Formation with Langerhans Cells | PLoS Pathogens | 2011 | 76 |
| 31 | Dendritic Cells Modulate Lung Response toPseudomonas aeruginosain a Murine Model of Sepsis-Induced Immune Dysfunction | Journal of Immunology | 2008 | 71 |
| 32 | Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor | Stem Cells | 2012 | 71 |
| 33 | Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells | Genome Biology | 2016 | 67 |
| 34 | Regulatory T Cells in Systemic Sclerosis | Frontiers in Immunology | 2018 | 67 |
| 35 | Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia | JCI Insight | 2017 | 67 |
| 36 | Secretory IgA Induces Tolerogenic Dendritic Cells through SIGNR1 Dampening Autoimmunity in Mice | Journal of Immunology | 2013 | 66 |
| 37 | Driver mutations in USP8 wild-type Cushing’s disease | Neuro-Oncology | 2019 | 65 |
| 38 | Genetic regulation of recurrent spontaneous abortion in humans | Biomedical Journal | 2015 | 65 |
| 39 | Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis | Arthritis Research and Therapy | 2013 | 62 |
| 40 | IRAK1 functional genetic variant affects severity of septic shock* | Critical Care Medicine | 2010 | 61 |
| 41 | HIV‐1 Transmission in the Male Genital Tract | American Journal of Reproductive Immunology | 2011 | 61 |
| 42 | AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages | Cell Death and Disease | 2015 | 61 |
| 43 | Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice | Nature Biotechnology | 2002 | 60 |
| 44 | Inflammation and Disease Activity are Associated with High Circulating Cardiac Markers in Rheumatoid Arthritis Independently of Traditional Cardiovascular Risk Factors | Journal of Rheumatology | 2014 | 56 |
| 45 | Priming Dental Pulp Stem Cells from Human Exfoliated Deciduous Teeth with Fibroblast Growth Factor-2 Enhances Mineralization Within Tissue-Engineered Constructs Implanted in Craniofacial Bone Defects | Stem Cells Translational Medicine | 2019 | 56 |
| 46 | Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line | PLoS ONE | 2015 | 54 |
| 47 | Angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis | Annals of the Rheumatic Diseases | 2012 | 53 |
| 48 | FADD at the Crossroads between Cancer and Inflammation | Trends in Immunology | 2018 | 53 |
| 49 | Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair | Molecular Therapy - Nucleic Acids | 2018 | 53 |
| 50 | Virus-like infection induces human β cell dedifferentiation | JCI Insight | 2018 | 53 |
