| # | Title | Journal | Year | Citations |
|---|
| 1 | Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial | Lancet, The | 2005 | 3,840 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 3 | Antithrombotic Therapy for VTE Disease | Chest | 2012 | 3,745 |
| 4 | Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis | Lancet Infectious Diseases, The | 2018 | 3,672 |
| 5 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 6 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 7 | What low back pain is and why we need to pay attention | Lancet, The | 2018 | 2,444 |
| 8 | Bioelectrical impedance analysis?part I: review of principles and methods | Clinical Nutrition | 2004 | 2,089 |
| 9 | The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks | Annual Review of Physiology | 2010 | 1,971 |
| 10 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis | Lancet Oncology, The | 2009 | 1,920 |
| 11 | Updated Clinical Classification of Pulmonary Hypertension | Journal of the American College of Cardiology | 2009 | 1,919 |
| 12 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update | Annals of the Rheumatic Diseases | 2020 | 1,860 |
| 13 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 14 | Bioelectrical impedance analysis—part II: utilization in clinical practice | Clinical Nutrition | 2004 | 1,643 |
| 15 | Osteomyelitis | Lancet, The | 2004 | 1,612 |
| 16 | ESPEN guideline on clinical nutrition in the intensive care unit | Clinical Nutrition | 2019 | 1,610 |
| 17 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 18 | EEG source imaging | Clinical Neurophysiology | 2004 | 1,508 |
| 19 | Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial | Lancet, The | 2019 | 1,494 |
| 20 | Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial | Lancet Oncology, The | 2014 | 1,356 |
| 21 | Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study | CardioVascular and Interventional Radiology | 2010 | 1,329 |
| 22 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 23 | Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? | Nature Reviews Microbiology | 2007 | 1,255 |
| 24 | Plethysmographic dynamic indices predict fluid responsiveness in septic ventilated patients | Intensive Care Medicine | 2007 | 1,242 |
| 25 | A review of content-based image retrieval systems in medical applications—clinical benefits and future directions | International Journal of Medical Informatics | 2004 | 1,223 |
| 26 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting | Anesthesia and Analgesia | 2014 | 1,200 |
| 27 | Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,153 |
| 28 | Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy | Cell | 2017 | 1,124 |
| 29 | Epidemiology and outcome of acute lung injury in European intensive care units | Intensive Care Medicine | 2004 | 1,123 |
| 30 | The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material | Intensive Care Medicine | 2012 | 1,112 |
| 31 | Romosozumab Treatment in Postmenopausal Women with Osteoporosis | New England Journal of Medicine | 2016 | 1,099 |
| 32 | Decreased serum brain-derived neurotrophic factor levels in major depressed patients | Psychiatry Research | 2002 | 1,061 |
| 33 | Interleukin-6 and chronic inflammation | Arthritis Research and Therapy | 2006 | 1,044 |
| 34 | The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women | Osteoporosis International | 2007 | 1,017 |
| 35 | Diagnosis of Ventilator-associated Pneumonia by Bacteriologic Analysis of Bronchoscopic and Nonbronchoscopic “Blind” Bronchoalveolar Lavage Fluid | The American Review of Respiratory Disease | 1991 | 1,010 |
| 36 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 37 | EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 979 |
| 38 | COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study | The Lancet Child and Adolescent Health | 2020 | 978 |
| 39 | Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline | Clinical Microbiology and Infection | 2018 | 942 |
| 40 | Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? | PLoS Medicine | 2016 | 929 |
| 41 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 42 | Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study | Lancet, The | 2020 | 919 |
| 43 | Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity | Anesthesiology | 2012 | 918 |
| 44 | Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2 | Nature Genetics | 2000 | 910 |
| 45 | 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours | European Journal of Cancer | 2011 | 895 |
| 46 | 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) | Annals of Oncology | 2018 | 891 |
| 47 | Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice | Diabetes | 2011 | 881 |
| 48 | Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report | Lancet Oncology, The | 2012 | 872 |
| 49 | Fluid responsiveness in mechanically ventilated patients: a review of indices used in intensive care | Intensive Care Medicine | 2003 | 864 |
| 50 | Ageing and infection | Lancet Infectious Diseases, The | 2002 | 837 |
