| ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 4.4K |
| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 3.8K |
| Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions | Nature Nanotechnology | 2016 | 561 |
| Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial | Lancet, The | 2016 | 359 |
| Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial | Lancet, The | 2016 | 325 |
| Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 314 |
| Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets | Clinical Cancer Research | 2016 | 242 |
| Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses | Journal of Clinical Epidemiology | 2016 | 207 |
| New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk | Nature Communications | 2016 | 180 |
| Defining secondary progressive multiple sclerosis | Brain | 2016 | 172 |
| CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape | Cell Reports | 2016 | 171 |
| Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2016 | 164 |
| Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant | American Journal of Human Genetics | 2016 | 153 |
| Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy | Canadian Journal of Cardiology | 2016 | 146 |
| Malnutrition at Hospital Admission-Contributors and Effect on Length of Stay: A Prospective Cohort Study From the Canadian Malnutrition Task Force | Journal of Parenteral and Enteral Nutrition | 2016 | 143 |
| The impact of migration on tuberculosis epidemiology and control in high-income countries: a review | BMC Medicine | 2016 | 143 |
| Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas | Clinical Cancer Research | 2016 | 130 |
| Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal | Cell Stem Cell | 2016 | 129 |
| Pioglitazone use and risk of bladder cancer: population based cohort study | BMJ, The | 2016 | 126 |
| Systematic Review of the Mediterranean Diet for Long-Term Weight Loss | American Journal of Medicine | 2016 | 122 |
| Obesity and Multiple Sclerosis: A Mendelian Randomization Study | PLoS Medicine | 2016 | 115 |
| An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies | Genome Biology | 2016 | 113 |
| Anastrozole versus tamoxifen in postmenopausal women with ductal carcinoma in situ undergoing lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial | Lancet, The | 2016 | 111 |
| Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study | PLoS Medicine | 2016 | 110 |
| Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors | Acta Neuropathologica | 2016 | 105 |
