| Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 6.1K |
| Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial | Lancet Oncology, The | 2015 | 1.9K |
| The UK10K project identifies rare variants in health and disease | Nature | 2015 | 776 |
| Targeting the translation machinery in cancer | Nature Reviews Drug Discovery | 2015 | 477 |
| Diagnostic criteria for the classification of cancer-associated weight loss | Journal of Clinical Oncology | 2015 | 366 |
| Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture | Nature | 2015 | 308 |
| Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study | PLoS Medicine | 2015 | 252 |
| The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension | Canadian Journal of Cardiology | 2015 | 222 |
| Safety and activity of the anti-CD79B antibody-drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study | Lancet Oncology, The | 2015 | 189 |
| Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel | Nature Communications | 2015 | 186 |
| Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 | Oncogene | 2015 | 167 |
| Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation | Cell Death and Differentiation | 2015 | 165 |
| The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA | Retrovirology | 2015 | 156 |
| A systematic review of factors influencing older adults' decision to accept or decline cancer treatment | Cancer Treatment Reviews | 2015 | 152 |
| A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force | Bipolar Disorders | 2015 | 146 |
| Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS) | Journal of Pain | 2015 | 140 |
| Age and dPCR can predict relapse in CML patients who discontinued imatinib: the ISAV study | American Journal of Hematology | 2015 | 139 |
| Transcatheter heart valve failure: a systematic review | European Heart Journal | 2015 | 137 |
| Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2) | European Respiratory Journal | 2015 | 131 |
| Germline RECQL mutations are associated with breast cancer susceptibility | Nature Genetics | 2015 | 123 |
| Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors | Aging Cell | 2015 | 116 |
| Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial | Lancet Oncology, The | 2015 | 115 |
| Inhaled corticosteroids in COPD: the clinical evidence | European Respiratory Journal | 2015 | 111 |
| Sentinel lymph node procedure in endometrial cancer: A systematic review and proposal for standardization of future research | Gynecologic Oncology | 2015 | 110 |
| Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk, and Predictors | Circulation | 2015 | 103 |
