| # | Title | Journal | Year | Citations |
|---|
| 1 | RoB 2: a revised tool for assessing risk of bias in randomised trials | BMJ: British Medical Journal | 2019 | 10,984 |
| 2 | Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 10,755 |
| 3 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 4 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography | Journal of the American Society of Echocardiography | 2010 | 5,724 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit | Critical Care Medicine | 2013 | 3,066 |
| 7 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 8 | Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial | Lancet Oncology, The | 2015 | 2,353 |
| 9 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 10 | The Metabolic Syndrome and Cardiovascular Risk | Journal of the American College of Cardiology | 2010 | 2,179 |
| 11 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 12 | Definitions and Diagnosis of Pulmonary Hypertension | Journal of the American College of Cardiology | 2013 | 1,467 |
| 13 | Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study | Lancet, The | 2020 | 1,395 |
| 14 | Common genetic determinants of vitamin D insufficiency: a genome-wide association study | Lancet, The | 2010 | 1,385 |
| 15 | Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study | Lancet Oncology, The | 2020 | 1,363 |
| 16 | Frailty: implications for clinical practice and public health | Lancet, The | 2019 | 1,341 |
| 17 | Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration | Cell | 2012 | 1,112 |
| 18 | An atlas of genetic influences on human blood metabolites | Nature Genetics | 2014 | 1,084 |
| 19 | Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2014 | 1,051 |
| 20 | Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study | Lancet Oncology, The | 2011 | 1,028 |
| 21 | Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial | Lancet, The | 1999 | 957 |
| 22 | Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update | Cancer | 1983 | 924 |
| 23 | Common mental health problems in immigrants and refugees: general approach in primary care | Cmaj | 2011 | 897 |
| 24 | Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2007 | 887 |
| 25 | Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes | BMJ: British Medical Journal | 2010 | 859 |
| 26 | Frailty Assessment in the Cardiovascular Care of Older Adults | Journal of the American College of Cardiology | 2014 | 850 |
| 27 | Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells | Cancer Research | 2007 | 845 |
| 28 | Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis | BMJ: British Medical Journal | 2019 | 822 |
| 29 | Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin) | Journal of the National Cancer Institute | 2001 | 815 |
| 30 | Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions | Nature Nanotechnology | 2016 | 810 |
| 31 | A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy | Allergy, Asthma and Clinical Immunology | 2013 | 792 |
| 32 | Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts | PLoS Medicine | 2013 | 753 |
| 33 | Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | European Heart Journal Cardiovascular Imaging | 2014 | 739 |
| 34 | Targeting the translation machinery in cancer | Nature Reviews Drug Discovery | 2015 | 628 |
| 35 | Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? | Frontiers in Pharmacology | 2018 | 611 |
| 36 | High Rates of Forward Transmission Events after Acute/Early HIV‐1 Infection | Journal of Infectious Diseases | 2007 | 608 |
| 37 | Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer | New England Journal of Medicine | 2021 | 601 |
| 38 | Reduced Cardiotoxicity and Preserved Antitumor Efficacy of Liposome-Encapsulated Doxorubicin and Cyclophosphamide Compared With Conventional Doxorubicin and Cyclophosphamide in a Randomized, Multicenter Trial of Metastatic Breast Cancer | Journal of Clinical Oncology | 2001 | 599 |
| 39 | Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality | Thorax | 2012 | 589 |
| 40 | Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor | Nature | 1994 | 583 |
| 41 | Frailty in Older Adults Undergoing Aortic Valve Replacement | Journal of the American College of Cardiology | 2017 | 561 |
| 42 | An atlas of genetic influences on osteoporosis in humans and mice | Nature Genetics | 2019 | 557 |
| 43 | Efficacy of exercise-based cardiac rehabilitation post–myocardial infarction: A systematic review and meta-analysis of randomized controlled trials | American Heart Journal | 2011 | 542 |
| 44 | Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss | Journal of Clinical Oncology | 2015 | 538 |
| 45 | Hostile takeovers: viral appropriation of the NF-kB pathway | Journal of Clinical Investigation | 2001 | 531 |
| 46 | The Quebec Back Pain Disability Scale | Spine | 1995 | 527 |
| 47 | Cell Biology of Heme | American Journal of the Medical Sciences | 1999 | 517 |
| 48 | SEMANTIC MEMORY LOSS IN DEMENTIA OF ALZHEIMER'S TYPE | Brain | 1990 | 510 |
| 49 | Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial | Lancet, The | 2016 | 505 |
| 50 | Interferon regulatory factors: the next generation | Gene | 1999 | 494 |
