| # | Title | Journal | Year | Citations |
|---|
| 1 | Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment | Gastroenterology | 2007 | 1,547 |
| 2 | Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater | Journal of Clinical Oncology | 2019 | 1,144 |
| 3 | Defining Advance Care Planning for Adults: A Consensus Definition From a Multidisciplinary Delphi Panel | Journal of Pain and Symptom Management | 2017 | 987 |
| 4 | The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study | Intensive Care Medicine | 2009 | 881 |
| 5 | Family satisfaction with care in the intensive care unit: Results of a multiple center study* | Critical Care Medicine | 2002 | 841 |
| 6 | Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology | Journal of Thoracic Oncology | 2013 | 792 |
| 7 | Should Immunonutrition Become Routine in Critically Ill Patients? | JAMA - Journal of the American Medical Association | 2001 | 788 |
| 8 | A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients | New England Journal of Medicine | 2013 | 777 |
| 9 | Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification | Nature Genetics | 1994 | 773 |
| 10 | Glutamine supplementation in serious illness: A systematic review of the evidence* | Critical Care Medicine | 2002 | 695 |
| 11 | Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut | Microbiome | 2013 | 621 |
| 12 | Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool | Critical Care | 2011 | 564 |
| 13 | What matters most in end-of-life care: perceptions of seriously ill patients and their family members | Cmaj | 2006 | 552 |
| 14 | Sleep disturbance in cancer patients | Social Science and Medicine | 2002 | 540 |
| 15 | Intuition in the context of discovery | Cognitive Psychology | 1990 | 536 |
| 16 | Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina | Journal of the American College of Cardiology | 2004 | 502 |
| 17 | Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50% | Journal of Clinical Oncology | 2021 | 468 |
| 18 | Mucin‐type O ‐glycans in human colon and breast cancer: glycodynamics and functions | EMBO Reports | 2006 | 464 |
| 19 | Sensory circumventricular organs and brain homeostatic pathways | FASEB Journal | 1993 | 451 |
| 20 | Clinical safety of oral sildenafil citrate (VIAGRATM) in the treatment of erectile dysfunction | International Journal of Impotence Research | 1998 | 450 |
| 21 | Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial | Lancet, The | 2005 | 443 |
| 22 | Failure to Engage Hospitalized Elderly Patients and Their Families in Advance Care Planning | JAMA Internal Medicine | 2013 | 405 |
| 23 | Development and Validation of the Rome IV Diagnostic Questionnaire for Adults | Gastroenterology | 2016 | 400 |
| 24 | Adult Starvation and Disease‐Related Malnutrition | Journal of Parenteral and Enteral Nutrition | 2010 | 397 |
| 25 | Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors | Journal of Molecular Diagnostics | 2013 | 397 |
| 26 | A Randomized, Placebo-Controlled Trial of Pembrolizumab Plus Chemotherapy in Patients With Metastatic Squamous NSCLC: Protocol-Specified Final Analysis of KEYNOTE-407 | Journal of Thoracic Oncology | 2020 | 395 |
| 27 | ERS statement on respiratory muscle testing at rest and during exercise | European Respiratory Journal | 2019 | 379 |
| 28 | Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease | Nature Medicine | 1995 | 367 |
| 29 | The Relationship between Prostate Inflammation and Lower Urinary Tract Symptoms: Examination of Baseline Data from the REDUCE Trial | European Urology | 2008 | 358 |
| 30 | Nutrition therapy in the critical care setting: What is “best achievable” practice? An international multicenter observational study* | Critical Care Medicine | 2010 | 358 |
| 31 | Randomized Comparison of Gemcitabine, Dexamethasone, and Cisplatin Versus Dexamethasone, Cytarabine, and Cisplatin Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: NCIC-CTG LY.12 | Journal of Clinical Oncology | 2014 | 358 |
| 32 | Neuropathic pain: a practical guide for the clinician | Cmaj | 2006 | 356 |
| 33 | Arthroscopic Treatment of Isolated Type II SLAP Lesions | American Journal of Sports Medicine | 2009 | 338 |
| 34 | A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women | Fertility and Sterility | 2002 | 337 |
| 35 | FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial | Gut | 2017 | 330 |
| 36 | Barriers to Goals of Care Discussions With Seriously Ill Hospitalized Patients and Their Families | JAMA Internal Medicine | 2015 | 314 |
| 37 | Identifying critically-ill patients who will benefit most from nutritional therapy: Further validation of the “modified NUTRIC” nutritional risk assessment tool | Clinical Nutrition | 2016 | 312 |
| 38 | Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement | European Respiratory Journal | 2016 | 311 |
| 39 | Metabolic and nutritional support of critically ill patients: consensus and controversies | Critical Care | 2015 | 306 |
| 40 | Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9 | Nature Genetics | 1992 | 305 |
| 41 | Fecal microbiota transplantation: in perspective | Therapeutic Advances in Gastroenterology | 2016 | 302 |
| 42 | Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO and OH (CCO) Joint Guideline Update | Journal of Clinical Oncology | 2020 | 301 |
| 43 | Overall cardiovascular profile of sildenafil citrate | American Journal of Cardiology | 1999 | 293 |
| 44 | Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: Results of a randomized controlled trial | Critical Care Medicine | 2001 | 292 |
| 45 | Extreme Dysbiosis of the Microbiome in Critical Illness | MSphere | 2016 | 283 |
| 46 | Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial | Lancet Oncology, The | 2017 | 282 |
| 47 | Endoscopically removed malignant colorectal polyps: Clinicopathologic correlations | Gastroenterology | 1995 | 276 |
| 48 | Prognostic value of neurohumoral activation in patients with an acute myocardial infarction: Effect of captopril | Journal of the American College of Cardiology | 1994 | 274 |
| 49 | Decision-making in the ICU: perspectives of the substitute decision-maker | Intensive Care Medicine | 2003 | 273 |
| 50 | Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men | Journal of Applied Physiology | 1996 | 269 |
