| # | Title | Journal | Year | Citations |
|---|
| 1 | Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome | Science | 2006 | 5,356 |
| 2 | 2007 Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 4,778 |
| 3 | 2013 ESH/ESC Guidelines for the management of arterial hypertension | Journal of Hypertension | 2013 | 4,251 |
| 4 | Ventilator-associated Pneumonia | American Journal of Respiratory and Critical Care Medicine | 2002 | 3,085 |
| 5 | Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer | Immunity | 2013 | 2,983 |
| 6 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,487 |
| 7 | Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure | New England Journal of Medicine | 2008 | 1,421 |
| 8 | Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism | New England Journal of Medicine | 2018 | 1,237 |
| 9 | Immediate Percutaneous Coronary Intervention Is Associated With Better Survival After Out-of-Hospital Cardiac Arrest | Circulation: Cardiovascular Interventions | 2010 | 1,183 |
| 10 | 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 1,152 |
| 11 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 12 | Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial | Lancet, The | 2018 | 1,142 |
| 13 | Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study | Journal of the American College of Cardiology | 2002 | 855 |
| 14 | Rituximab versus Azathioprine for Maintenance in ANCA-Associated Vasculitis | New England Journal of Medicine | 2014 | 842 |
| 15 | Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability | Immunity | 2016 | 814 |
| 16 | Complement System Part II: Role in Immunity | Frontiers in Immunology | 2015 | 762 |
| 17 | Predictive Performance of the Modification of Diet in Renal Disease and Cockcroft-Gault Equations for Estimating Renal Function | Journal of the American Society of Nephrology: JASN | 2005 | 759 |
| 18 | FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis | Lancet Oncology, The | 2016 | 719 |
| 19 | Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism | JAMA - Journal of the American Medical Association | 2014 | 680 |
| 20 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2015 | 678 |
| 21 | Cancer classification using the Immunoscore: a worldwide task force | Journal of Translational Medicine | 2012 | 676 |
| 22 | Molecular Diversity of Lactobacillus spp. and Other Lactic Acid Bacteria in the Human Intestine as Determined by Specific Amplification of 16S Ribosomal DNA | Applied and Environmental Microbiology | 2002 | 619 |
| 23 | Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort | Lancet Diabetes and Endocrinology,the | 2017 | 595 |
| 24 | Rheumatic heart disease | Lancet, The | 2012 | 583 |
| 25 | Tinzaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients With Active Cancer | JAMA - Journal of the American Medical Association | 2015 | 530 |
| 26 | Anakinra for severe forms of COVID-19: a cohort study | Lancet Rheumatology, The | 2020 | 526 |
| 27 | Comparative Performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study Equations for Estimating GFR Levels Above 60 mL/min/1.73 m2 | American Journal of Kidney Diseases | 2010 | 507 |
| 28 | Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry | European Heart Journal | 2011 | 504 |
| 29 | The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004 | European Heart Journal | 2006 | 496 |
| 30 | Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort | Intensive Care Medicine | 2013 | 476 |
| 31 | Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial | Lancet, The | 2004 | 468 |
| 32 | Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review | European Heart Journal | 2008 | 460 |
| 33 | Advantages and disadvantages of 3-dimensional printing in surgery: A systematic review | Surgery | 2016 | 460 |
| 34 | Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation | Catheterization and Cardiovascular Interventions | 2003 | 458 |
| 35 | Screening for Vulnerability in Older Cancer Patients: The ONCODAGE Prospective Multicenter Cohort Study | PLoS ONE | 2014 | 437 |
| 36 | Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome | Nature Genetics | 2013 | 419 |
| 37 | Cardiovascular Disease in the Developing World | Journal of the American College of Cardiology | 2012 | 385 |
| 38 | Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management | Cancer | 2007 | 382 |
| 39 | An Individual Patient Data Metaanalysis of Outcomes and Prognostic Factors After Treatment of Oligometastatic Non–Small-Cell Lung Cancer | Clinical Lung Cancer | 2014 | 377 |
| 40 | Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial | Lancet, The | 2008 | 375 |
| 41 | Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies | Rheumatology | 2009 | 366 |
| 42 | The impact of donor-specific anti-HLA antibodies on late kidney allograft failure | Nature Reviews Nephrology | 2012 | 321 |
| 43 | Hepatocellular carcinoma: ESMO–ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2012 | 315 |
| 44 | Antibody-mediated vascular rejection of kidney allografts: a population-based study | Lancet, The | 2013 | 308 |
| 45 | Combined Complement Gene Mutations in Atypical Hemolytic Uremic Syndrome Influence Clinical Phenotype | Journal of the American Society of Nephrology: JASN | 2013 | 308 |
| 46 | Arterial stiffness and pulse pressure in CKD and ESRD | Kidney International | 2012 | 307 |
| 47 | Pulmonary embolism in patients with COVID-19 pneumonia | European Respiratory Journal | 2020 | 298 |
| 48 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review | Endoscopy | 2018 | 297 |
| 49 | Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR) | Resuscitation | 2020 | 295 |
| 50 | First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials | Lancet Oncology, The | 2017 | 293 |
