| # | Title | Journal | Year | Citations |
|---|
| 1 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | BMJ, The | 2021 | 26,066 |
| 2 | CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials | BMJ: British Medical Journal | 2010 | 5,319 |
| 3 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 4 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | Systematic Reviews | 2021 | 3,624 |
| 5 | PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews | BMJ, The | 2021 | 3,413 |
| 6 | CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials | International Journal of Surgery | 2012 | 1,546 |
| 7 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 8 | CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials | Journal of Clinical Epidemiology | 2010 | 1,500 |
| 9 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | PLoS Medicine | 2021 | 1,340 |
| 10 | Evaluation of D-Dimer in the Diagnosis of Suspected Deep-Vein Thrombosis | New England Journal of Medicine | 2003 | 1,329 |
| 11 | Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and d-dimer | Annals of Internal Medicine | 2001 | 1,198 |
| 12 | Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia | Nature | 2011 | 1,016 |
| 13 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | Journal of Clinical Epidemiology | 2021 | 995 |
| 14 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 978 |
| 15 | Validation of a Decision Regret Scale | Medical Decision Making | 2003 | 973 |
| 16 | PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews | Systematic Reviews | 2021 | 962 |
| 17 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 18 | A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy | Allergy, Asthma and Clinical Immunology | 2013 | 792 |
| 19 | ClassyFire: automated chemical classification with a comprehensive, computable taxonomy | Journal of Cheminformatics | 2016 | 779 |
| 20 | Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia | European Journal of Vascular and Endovascular Surgery | 2019 | 741 |
| 21 | Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers | Cmaj | 2004 | 726 |
| 22 | Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community | Cmaj | 2010 | 726 |
| 23 | Decision aids for patients facing health treatment or screening decisions: systematic review | BMJ: British Medical Journal | 1999 | 718 |
| 24 | Oral Anticoagulants vs Aspirin in Nonvalvular Atrial Fibrillation | JAMA - Journal of the American Medical Association | 2002 | 632 |
| 25 | Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial | Lancet Oncology, The | 2013 | 550 |
| 26 | Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study | Blood | 2014 | 505 |
| 27 | Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis | Archives of Neurology | 2005 | 483 |
| 28 | Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial | Lancet, The | 2017 | 469 |
| 29 | Effect of Study Setting on Anticoagulation Control | Chest | 2006 | 453 |
| 30 | Reliability of point-of-care testing for glucose measurement in critically ill adults* | Critical Care Medicine | 2005 | 430 |
| 31 | YouTube as a source of information on COVID-19: a pandemic of misinformation? | BMJ Global Health | 2020 | 417 |
| 32 | Does This Patient Have Deep Vein Thrombosis? | JAMA - Journal of the American Medical Association | 2006 | 403 |
| 33 | Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial | Lancet, The | 2020 | 400 |
| 34 | Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial | Lancet, The | 2017 | 391 |
| 35 | Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels | Journal of Neuroscience | 2001 | 381 |
| 36 | The Health of Primary Caregivers of Children With Cerebral Palsy: How Does It Compare With That of Other Canadian Caregivers? | Pediatrics | 2004 | 371 |
| 37 | The Concept of Femoroacetabular Impingement: Current Status and Future Perspectives | Clinical Orthopaedics and Related Research | 2009 | 366 |
| 38 | Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial | Lancet Neurology, The | 2012 | 351 |
| 39 | PRISMA harms checklist: improving harms reporting in systematic reviews | BMJ, The | 2016 | 351 |
| 40 | Leiomyomas beyond the Uterus: Unusual Locations, Rare Manifestations | Radiographics | 2008 | 342 |
| 41 | Socioeconomic status and risk of cardiovascular disease in 20 low-income, middle-income, and high-income countries: the Prospective Urban Rural Epidemiologic (PURE) study | The Lancet Global Health | 2019 | 340 |
| 42 | Global prevalence of mental health issues among the general population during the coronavirus disease-2019 pandemic: a systematic review and meta-analysis | Scientific Reports | 2021 | 335 |
| 43 | Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research | Biology of Blood and Marrow Transplantation | 2015 | 331 |
| 44 | Systematic Classification of Morbidity and Mortality After Thoracic Surgery | Annals of Thoracic Surgery | 2010 | 328 |
| 45 | EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer | BMC Cancer | 2012 | 325 |
| 46 | Utility of whole‐exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care | Clinical Genetics | 2016 | 323 |
| 47 | Prolonged Therapeutic Hypothermia After Traumatic Brain Injury in Adults | JAMA - Journal of the American Medical Association | 2003 | 316 |
| 48 | Risk communication in practice: the contribution of decision aids | BMJ: British Medical Journal | 2003 | 312 |
| 49 | Time-dependent bias was common in survival analyses published in leading clinical journals | Journal of Clinical Epidemiology | 2004 | 312 |
| 50 | Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials | Canadian Journal of Anaesthesia | 2011 | 306 |
