| 1 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 5,588 |
| 2 | Incidence, Predictors, and Outcome of Thrombosis After Successful Implantation of Drug-Eluting Stents | JAMA - Journal of the American Medical Association | 2005 | 2,792 |
| 3 | EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2017 | 2,602 |
| 4 | Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range | Diabetes Care | 2019 | 2,537 |
| 5 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 2,186 |
| 6 | Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease | Nature Reviews Clinical Oncology | 2016 | 2,167 |
| 7 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2021 | 1,970 |
| 8 | ESPEN guideline: Clinical nutrition in surgery | Clinical Nutrition | 2017 | 1,361 |
| 9 | Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors | Brain, Behavior, and Immunity | 2020 | 1,294 |
| 10 | Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance | Sleep Medicine | 2014 | 1,251 |
| 11 | Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors | Cancer Cell | 2005 | 1,231 |
| 12 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,214 |
| 13 | A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1 | Science | 2007 | 1,160 |
| 14 | Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,096 |
| 15 | Epidemiology of Renal Cell Carcinoma | European Urology | 2019 | 1,091 |
| 16 | Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells | Nature Medicine | 2018 | 1,089 |
| 17 | A Practical Two-Step Quantitative Clinical and Electrophysiological Assessment for the Diagnosis and Staging of Diabetic Neuropathy | Diabetes Care | 1994 | 1,081 |
| 18 | Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis | Nature | 2003 | 1,065 |
| 19 | Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection | JAMA Pediatrics | 2021 | 1,062 |
| 20 | Randomized Study to Assess the Effectiveness of Slow- and Moderate-Release Polymer-Based Paclitaxel-Eluting Stents for Coronary Artery Lesions | Circulation | 2003 | 959 |
| 21 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation | Circulation | 2004 | 958 |
| 22 | 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial | Lancet, The | 2017 | 840 |
| 23 | European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update | European Urology | 2022 | 799 |
| 24 | The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee | Blood | 2022 | 797 |
| 25 | EAE/ASE Recommendations for Image Acquisition and Display Using Three-Dimensional Echocardiography | Journal of the American Society of Echocardiography | 2012 | 793 |
| 26 | Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911) | Lancet, The | 2012 | 785 |
| 27 | Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines | Clinical Neurophysiology | 2021 | 781 |
| 28 | Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts | Nature | 1991 | 775 |
| 29 | HER2-positive breast cancer | Lancet, The | 2017 | 769 |
| 30 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer | European Urology | 2021 | 766 |
| 31 | Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism | Nature | 2005 | 764 |
| 32 | Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study | Brain | 2019 | 756 |
| 33 | Enhanced Recovery Program in Colorectal Surgery: A Meta‐analysis of Randomized Controlled Trials | World Journal of Surgery | 2014 | 740 |
| 34 | European/Canadian multicenter, double‐blind, randomized, placebo‐controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosis | Annals of Neurology | 2001 | 703 |
| 35 | Can Clinically Significant Prostate Cancer Be Detected with Multiparametric Magnetic Resonance Imaging? A Systematic Review of the Literature | European Urology | 2015 | 688 |
| 36 | EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma | Lancet Oncology, The | 2014 | 678 |
| 37 | Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration | Nature Biotechnology | 2006 | 664 |
| 38 | Treatment landscape of triple-negative breast cancer — expanded options, evolving needs | Nature Reviews Clinical Oncology | 2022 | 646 |
| 39 | Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study | Diabetologia | 1996 | 632 |
| 40 | Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine | Molecular Psychiatry | 1998 | 612 |
| 41 | International standardization of diagnostic criteria for microvascular angina | International Journal of Cardiology | 2018 | 586 |
| 42 | Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells | Cancer Cell | 2011 | 568 |
| 43 | Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia | Blood | 2021 | 568 |
| 44 | Erectile dysfunction | Nature Reviews Disease Primers | 2016 | 564 |
| 45 | “Ultrasound Comet-Tail Images”: A Marker Of Pulmonary Edema | Chest | 2005 | 562 |
| 46 | Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study | Lancet, The | 2013 | 557 |
| 47 | The Southampton Consensus Guidelines for Laparoscopic Liver Surgery | Annals of Surgery | 2018 | 552 |
| 48 | β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex | Neuron | 2001 | 539 |
| 49 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 531 |
| 50 | Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients | Blood | 2020 | 530 |
