| # | Title | Journal | Year | Citations |
|---|
| 1 | Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia | New England Journal of Medicine | 2017 | 1,443 |
| 2 | Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial | Lancet, The | 2002 | 1,340 |
| 3 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 4 | Intensive Care Delirium Screening Checklist: evaluation of a new screening tool | Intensive Care Medicine | 2001 | 1,203 |
| 5 | Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia | Nature Genetics | 1999 | 1,036 |
| 6 | Mortality in systemic lupus erythematosus | Arthritis and Rheumatism | 2006 | 924 |
| 7 | Incidence, risk factors and consequences of ICU delirium | Intensive Care Medicine | 2007 | 869 |
| 8 | Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial | Lancet, The | 2016 | 724 |
| 9 | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis | Nature Genetics | 2012 | 692 |
| 10 | Neural control of mechanical ventilation in respiratory failure | Nature Medicine | 1999 | 573 |
| 11 | Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age | Blood | 1996 | 476 |
| 12 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 13 | Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy | Cancer | 2010 | 456 |
| 14 | Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial | Arthritis and Rheumatism | 2003 | 452 |
| 15 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 16 | Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial | Lancet, The | 2014 | 425 |
| 17 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 18 | Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer | Scientific Reports | 2017 | 391 |
| 19 | Identification of a cadherin cell adhesion recognition sequence | Developmental Biology | 1990 | 368 |
| 20 | Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies | Cell Stem Cell | 2018 | 345 |
| 21 | The role of viscosupplementation with hylan G-F 20 (Synvisc®) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone | Osteoarthritis and Cartilage | 1995 | 337 |
| 22 | Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis | Blood | 2014 | 337 |
| 23 | An international cohort study of cancer in systemic lupus erythematosus | Arthritis and Rheumatism | 2005 | 333 |
| 24 | The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group | Nature Reviews Nephrology | 2019 | 330 |
| 25 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 26 | Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study | Lancet, The | 2014 | 322 |
| 27 | Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials | BMJ, The | 2021 | 322 |
| 28 | Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer | Cancer | 2006 | 310 |
| 29 | Subsyndromal delirium in the ICU: evidence for a disease spectrum | Intensive Care Medicine | 2007 | 307 |
| 30 | Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host | Nature | 2018 | 296 |
| 31 | A Multimodal Analgesia Protocol for Total Knee Arthroplasty | Journal of Bone and Joint Surgery - Series A | 2006 | 287 |
| 32 | The Epidural Test Dose: A Review | Anesthesia and Analgesia | 2006 | 274 |
| 33 | Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial | Blood | 2010 | 273 |
| 34 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 35 | BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal | Journal of Neuroscience | 2009 | 268 |
| 36 | Protocolized Intensive Care Unit Management of Analgesia, Sedation, and Delirium Improves Analgesia and Subsyndromal Delirium Rates | Anesthesia and Analgesia | 2010 | 259 |
| 37 | Molecular Cloning of the Human Gene, PNKP, Encoding a Polynucleotide Kinase 3′-Phosphatase and Evidence for Its Role in Repair of DNA Strand Breaks Caused by Oxidative Damage | Journal of Biological Chemistry | 1999 | 258 |
| 38 | Methemoglobinemia Related to Local Anesthetics: A Summary of 242 Episodes | Anesthesia and Analgesia | 2009 | 252 |
| 39 | BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery | Journal of Neuroscience | 2010 | 251 |
| 40 | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial | BMJ, The | 2021 | 250 |
| 41 | Alignment options for total knee arthroplasty: A systematic review | Orthopaedics and Traumatology: Surgery and Research | 2017 | 248 |
| 42 | Conformational Rearrangement in C-Reactive Protein Is Required for Proinflammatory Actions on Human Endothelial Cells | Circulation | 2004 | 245 |
| 43 | Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport | Clinical Pharmacology and Therapeutics | 2008 | 243 |
| 44 | Role of seminal plasma phospholipid-binding proteins in sperm membrane lipid modification that occurs during capacitation | Journal of Reproductive Immunology | 2002 | 241 |
| 45 | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF- B and AP-1 activation, and IL-8 gene expression in human leukocytes | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 240 |
| 46 | A role for ultraviolet A in solar mutagenesis. | Proceedings of the National Academy of Sciences of the United States of America | 1995 | 239 |
| 47 | Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 238 |
| 48 | Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold | Biomaterials | 2014 | 233 |
| 49 | Fidaxomicin Versus Vancomycin for Clostridium difficile Infection: Meta-analysis of Pivotal Randomized Controlled Trials | Clinical Infectious Diseases | 2012 | 228 |
| 50 | New insights towards understanding the mechanisms of sperm protection by egg yolk and milk | Molecular Reproduction and Development | 2006 | 225 |
