| # | Title | Journal | Year | Citations |
|---|
| 1 | Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention | New England Journal of Medicine | 2009 | 3,510 |
| 2 | FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2015 | 2,188 |
| 3 | Measurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses | New England Journal of Medicine | 1996 | 2,013 |
| 4 | Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial | Lancet Oncology, The | 2015 | 1,861 |
| 5 | Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised | BMJ: British Medical Journal | 2000 | 1,833 |
| 6 | Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial | Lancet, The | 2000 | 1,654 |
| 7 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 8 | Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial | Lancet Oncology, The | 2014 | 1,356 |
| 9 | Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials | Lancet Oncology, The | 2015 | 1,220 |
| 10 | FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2010 | 1,147 |
| 11 | Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study | Journal of the American College of Cardiology | 2010 | 1,077 |
| 12 | Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. | Circulation | 1993 | 1,032 |
| 13 | Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer | New England Journal of Medicine | 2018 | 1,012 |
| 14 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease | Journal of the American College of Cardiology | 2010 | 990 |
| 15 | Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy | Journal of Clinical Oncology | 2012 | 873 |
| 16 | Fractional Flow Reserve to Determine the Appropriateness of Angioplasty in Moderate Coronary Stenosis | Circulation | 2001 | 804 |
| 17 | Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial | Lancet, The | 2007 | 803 |
| 18 | Fractional Flow Reserve | Circulation | 1995 | 669 |
| 19 | Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial | Journal of Clinical Oncology | 2020 | 665 |
| 20 | Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II) | Lancet, The | 1998 | 613 |
| 21 | Risk factors for anastomotic failure after total mesorectal excision of rectal cancer | British Journal of Surgery | 2005 | 601 |
| 22 | Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial | Lancet, The | 2007 | 593 |
| 23 | Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation | Lancet Oncology, The | 2020 | 588 |
| 24 | Neurologic complications associated with endovascular repair of thoracic aortic pathology: Incidence and risk factors. A study from the European Collaborators on Stent/Graft Techniques for Aortic Aneurysm Repair (EUROSTAR) Registry | Journal of Vascular Surgery | 2007 | 547 |
| 25 | Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia | JAMA - Journal of the American Medical Association | 2014 | 545 |
| 26 | Drug-Eluting and Bare Nitinol Stents for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery:Long-term Results From the SIROCCO Trial | Journal of Endovascular Therapy | 2006 | 468 |
| 27 | Significance of endoleaks after endovascular repair of abdominal aortic aneurysms: The EUROSTAR experience | Journal of Vascular Surgery | 2002 | 446 |
| 28 | Abnormal Epicardial Coronary Resistance in Patients With Diffuse Atherosclerosis but “Normal” Coronary Angiography | Circulation | 2001 | 427 |
| 29 | Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group | Lancet, The | 2015 | 421 |
| 30 | Evaluation of the Second Generation of a Bioresorbable Everolimus-Eluting Vascular Scaffold for the Treatment of De Novo Coronary Artery Stenosis | Journal of the American College of Cardiology | 2011 | 410 |
| 31 | E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi | Surgical Endoscopy and Other Interventional Techniques | 1999 | 407 |
| 32 | Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors | International Journal of Cancer | 2014 | 404 |
| 33 | Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD) | Annals of Surgery | 2019 | 401 |
| 34 | Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial | The Lancet Gastroenterology and Hepatology | 2019 | 393 |
| 35 | Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial | Lancet Oncology, The | 2016 | 385 |
| 36 | Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT) | BMJ: British Medical Journal | 2010 | 375 |
| 37 | Survival after relapse in patients with endometrial cancer: results from a randomized trial☆ | Gynecologic Oncology | 2003 | 345 |
| 38 | The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials | European Journal of Nuclear Medicine and Molecular Imaging | 2008 | 343 |
| 39 | Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial | Lancet, The | 2013 | 343 |
| 40 | Fractional Flow Reserve in Patients With Prior Myocardial Infarction | Circulation | 2001 | 342 |
| 41 | Economic Evaluation of Fractional Flow Reserve–Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease | Circulation | 2010 | 332 |
| 42 | Cerebral function in diabetes mellitus | Diabetologia | 1994 | 313 |
| 43 | Psychosocial Predictors of Success following Bariatric Surgery | Obesity Surgery | 2005 | 310 |
| 44 | Intracoronary and Intravenous Adenosine 5′-Triphosphate, Adenosine, Papaverine, and Contrast Medium to Assess Fractional Flow Reserve in Humans | Circulation | 2003 | 309 |
| 45 | Consideration of Dose Limits for Organs at Risk of Thoracic Radiotherapy: Atlas for Lung, Proximal Bronchial Tree, Esophagus, Spinal Cord, Ribs, and Brachial Plexus | International Journal of Radiation Oncology Biology Physics | 2011 | 309 |
| 46 | Neoadjuvant (Chemo)radiotherapy With Total Mesorectal Excision Only Is Not Sufficient to Prevent Lateral Local Recurrence in Enlarged Nodes: Results of the Multicenter Lateral Node Study of Patients With Low cT3/4 Rectal Cancer | Journal of Clinical Oncology | 2019 | 308 |
| 47 | Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years | British Journal of Surgery | 2017 | 304 |
| 48 | Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial | Annals of Oncology | 2015 | 302 |
| 49 | Multicenter Core Laboratory Comparison of the Instantaneous Wave-Free Ratio and Resting P /P With Fractional Flow Reserve | Journal of the American College of Cardiology | 2014 | 301 |
| 50 | Early complications and endoleaks after endovascular abdominal aortic aneurysm repair: Report of a multicenter study | Journal of Vascular Surgery | 2000 | 299 |
