| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,334 |
| 2 | VSEARCH: a versatile open source tool for metagenomics | PeerJ | 2016 | 7,714 |
| 3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 7,596 |
| 4 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission | Lancet, The | 2020 | 5,584 |
| 5 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,887 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 7 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 4,243 |
| 8 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,158 |
| 9 | Photodynamic therapy of cancer: An update | Ca-A Cancer Journal for Clinicians | 2011 | 4,093 |
| 10 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,886 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 12 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,921 |
| 13 | Rab GTPases as coordinators of vesicle traffic | Nature Reviews Molecular Cell Biology | 2009 | 2,878 |
| 14 | ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility | Molecular Cell | 2013 | 2,708 |
| 15 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,403 |
| 16 | Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease | Gastroenterology | 2015 | 2,317 |
| 17 | Consensus statement on concussion in sport—the 5thinternational conference on concussion in sport held in Berlin, October 2016 | British Journal of Sports Medicine | 2017 | 2,208 |
| 18 | Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver | Nature Cell Biology | 2015 | 2,155 |
| 19 | The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial | Lancet, The | 2011 | 2,136 |
| 20 | Estimates of global seasonal influenza-associated respiratory mortality: a modelling study | Lancet, The | 2018 | 2,042 |
| 21 | Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 2,012 |
| 22 | 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk | Atherosclerosis | 2019 | 1,953 |
| 23 | Studies Comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for Assessment of Pain Intensity in Adults: A Systematic Literature Review | Journal of Pain and Symptom Management | 2011 | 1,909 |
| 24 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support | Resuscitation | 2010 | 1,881 |
| 25 | Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women | Lancet, The | 2016 | 1,874 |
| 26 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,836 |
| 27 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,824 |
| 28 | Current knowledge on exosome biogenesis and release | Cellular and Molecular Life Sciences | 2018 | 1,791 |
| 29 | Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012 | British Journal of Sports Medicine | 2013 | 1,773 |
| 30 | Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11) | Pain | 2019 | 1,757 |
| 31 | Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk | Nature Genetics | 2019 | 1,754 |
| 32 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,744 |
| 33 | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | Nature Genetics | 2019 | 1,741 |
| 34 | Mutational Processes Molding the Genomes of 21 Breast Cancers | Cell | 2012 | 1,720 |
| 35 | Identification of common genetic risk variants for autism spectrum disorder | Nature Genetics | 2019 | 1,708 |
| 36 | Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies | International Journal of Epidemiology | 2017 | 1,597 |
| 37 | Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies | Lancet Neurology, The | 2019 | 1,596 |
| 38 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,561 |
| 39 | Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use | Nature Genetics | 2019 | 1,443 |
| 40 | Genome-wide association analysis identifies 13 new risk loci for schizophrenia | Nature Genetics | 2013 | 1,411 |
| 41 | Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research | Cancer Discovery | 2014 | 1,400 |
| 42 | Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection | Nature Genetics | 2018 | 1,392 |
| 43 | The Oslo definitions for coeliac disease and related terms | Gut | 2013 | 1,350 |
| 44 | Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging | European Heart Journal Cardiovascular Imaging | 2013 | 1,349 |
| 45 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision | Journal of Allergy and Clinical Immunology | 2017 | 1,293 |
| 46 | The Life History of 21 Breast Cancers | Cell | 2012 | 1,287 |
| 47 | The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes | Nature Communications | 2016 | 1,287 |
| 48 | JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework | Nucleic Acids Research | 2018 | 1,276 |
| 49 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,268 |
| 50 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 1,236 |
