| # | Title | Journal | Year | Citations |
|---|
| 1 | Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma | New England Journal of Medicine | 2005 | 17,395 |
| 2 | Expert consensus document on arterial stiffness: methodological issues and clinical applications | European Heart Journal | 2006 | 5,012 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Wound repair and regeneration | Nature | 2008 | 4,690 |
| 5 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 7 | Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,644 |
| 8 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 9 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 10 | Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 2,191 |
| 11 | First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2017 | 2,145 |
| 12 | Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus | Nature | 2005 | 2,136 |
| 13 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock | Intensive Care Medicine | 2004 | 2,079 |
| 14 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,078 |
| 15 | Macrophage migration inhibitory factor: a regulator of innate immunity | Nature Reviews Immunology | 2003 | 2,045 |
| 16 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 17 | Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis | Lancet Respiratory Medicine,the | 2019 | 1,866 |
| 18 | Alectinib versus Crizotinib in Untreated ALK-Positive Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2017 | 1,858 |
| 19 | Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group | Journal of the American Medical Directors Association | 2013 | 1,767 |
| 20 | Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study | Lancet Respiratory Medicine,the | 2015 | 1,755 |
| 21 | 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer | Clinical Infectious Diseases | 2002 | 1,738 |
| 22 | Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) | Clinical Neurophysiology | 2014 | 1,647 |
| 23 | ESPEN guideline on clinical nutrition in the intensive care unit | Clinical Nutrition | 2019 | 1,610 |
| 24 | Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 1,571 |
| 25 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 26 | Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501) | Head and Neck | 2005 | 1,412 |
| 27 | An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma | Cell | 2019 | 1,408 |
| 28 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus | Nature | 2005 | 1,272 |
| 29 | The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. | Stroke | 1988 | 1,241 |
| 30 | Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance | Nature Reviews Clinical Oncology | 2019 | 1,235 |
| 31 | Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) | Clinical Neurophysiology | 2017 | 1,213 |
| 32 | Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape | Science | 1996 | 1,206 |
| 33 | Optimized exosome isolation protocol for cell culture supernatant and human plasma | Journal of Extracellular Vesicles | 2015 | 1,204 |
| 34 | Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges | Nature Reviews Clinical Oncology | 2018 | 1,192 |
| 35 | IFNα activates dormant haematopoietic stem cells in vivo | Nature | 2009 | 1,181 |
| 36 | Interactions between cancer stem cells and their niche govern metastatic colonization | Nature | 2012 | 1,167 |
| 37 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 38 | Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 | World Journal of Surgery | 2019 | 1,166 |
| 39 | Why do young people drink? A review of drinking motives | Clinical Psychology Review | 2005 | 1,163 |
| 40 | Replication of hepatitis C virus | Nature Reviews Microbiology | 2007 | 1,158 |
| 41 | Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy | Cell | 2017 | 1,124 |
| 42 | Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group | Clinical Nutrition | 2014 | 1,108 |
| 43 | 2016 updated EULAR evidence-based recommendations for the management of gout | Annals of the Rheumatic Diseases | 2017 | 1,096 |
| 44 | Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial | Lancet Oncology, The | 2012 | 1,075 |
| 45 | Real estimates of mortality following COVID-19 infection | Lancet Infectious Diseases, The | 2020 | 988 |
| 46 | EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 979 |
| 47 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 48 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 49 | Skewed maturation of memory HIV-specific CD8 T lymphocytes | Nature | 2001 | 910 |
| 50 | Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial | Lancet, The | 2005 | 880 |
