| # | Title | Journal | Year | Citations |
|---|
| 1 | Emergence of Fluoroquinolones as the Predominant Risk Factor for Clostridium difficile-Associated Diarrhea: A Cohort Study during an Epidemic in Quebec | Clinical Infectious Diseases | 2005 | 898 |
| 2 | The instability severity index score | Journal of Bone and Joint Surgery: British Volume | 2007 | 735 |
| 3 | 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations | Canadian Journal of Cardiology | 2009 | 653 |
| 4 | Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis | Arthritis and Rheumatism | 2008 | 507 |
| 5 | Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans | Journal of Clinical Endocrinology and Metabolism | 2011 | 473 |
| 6 | F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction and Suspected Coronary Disease | Journal of the American College of Cardiology | 2007 | 403 |
| 7 | Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors | Nature Genetics | 2019 | 402 |
| 8 | THE FUNCTIONAL AUTONOMY MEASUREMENT SYSTEM (SMAF): DESCRIPTION AND VALIDATION OF AN INSTRUMENT FOR THE MEASUREMENT OF HANDICAPS | Age and Ageing | 1988 | 386 |
| 9 | Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring | Circulation | 2019 | 345 |
| 10 | High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies | American Journal of Human Genetics | 2017 | 337 |
| 11 | Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study | Lancet, The | 2016 | 299 |
| 12 | Impact of a Reduction in the Use of High-Risk Antibiotics on the Course of an Epidemic of Clostridium difficile-Associated Disease Caused by the Hypervirulent NAP1/027 Strain | Clinical Infectious Diseases | 2007 | 294 |
| 13 | Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant | JAMA Internal Medicine | 2019 | 283 |
| 14 | Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial | Lancet Oncology, The | 2014 | 239 |
| 15 | PANCREOX: A Randomized Phase III Study of Fluorouracil/Leucovorin With or Without Oxaliplatin for Second-Line Advanced Pancreatic Cancer in Patients Who Have Received Gemcitabine-Based Chemotherapy | Journal of Clinical Oncology | 2016 | 210 |
| 16 | Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike | Cell Reports Medicine | 2020 | 200 |
| 17 | Long-term Durability of Sacral Nerve Stimulation Therapy for Chronic Fecal Incontinence | Diseases of the Colon and Rectum | 2013 | 196 |
| 18 | A polymer-coated, paclitaxel-eluting stent (Eluvia) versus a polymer-free, paclitaxel-coated stent (Zilver PTX) for endovascular femoropopliteal intervention (IMPERIAL): a randomised, non-inferiority trial | Lancet, The | 2018 | 196 |
| 19 | Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial | Intensive Care Medicine | 2006 | 193 |
| 20 | Acute lung injury in children: Therapeutic practice and feasibility of international clinical trials* | Pediatric Critical Care Medicine | 2010 | 188 |
| 21 | Cardiac rehabilitation past, present and future: an overview | Cardiovascular Diagnosis and Therapy | 2012 | 180 |
| 22 | The Cardiomyopathy of Friedreich's Ataxia Morphological Observations in 3 Cases | Canadian Journal of Neurological Sciences | 1980 | 177 |
| 23 | Long-term Efficacy and Safety of Sacral Nerve Stimulation for Fecal Incontinence | Diseases of the Colon and Rectum | 2011 | 172 |
| 24 | Cystic Fibrosis Lung Inflammation: Early, Sustained, and Severe | American Journal of Respiratory and Critical Care Medicine | 1995 | 159 |
| 25 | Increasing Benefit From Revascularization Is Associated With Increasing Amounts of Myocardial Hibernation | JACC: Cardiovascular Imaging | 2009 | 159 |
| 26 | Treatment strategies in patients with statin intolerance: The Cleveland Clinic experience | American Heart Journal | 2013 | 154 |
| 27 | Risk ofClostridium difficileInfection after Perioperative Antibacterial Prophylaxis before and during an Outbreak of Infection due to a Hypervirulent Strain | Clinical Infectious Diseases | 2008 | 153 |
| 28 | Duration of Androgen Deprivation Therapy in High-risk Prostate Cancer: A Randomized Phase III Trial | European Urology | 2018 | 152 |
| 29 | Effects of D-Chiro-Inositol in Lean Women with the Polycystic Ovary Syndrome | Endocrine Practice | 2002 | 150 |
| 30 | Antioxidant vitamins supplementation and mortality: A randomized trial in head and neck cancer patients | International Journal of Cancer | 2006 | 149 |
| 31 | Symptomatic internal hernias after laparoscopic bariatric surgery | Surgical Endoscopy and Other Interventional Techniques | 2005 | 145 |
| 32 | Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial | Lancet Oncology, The | 2015 | 142 |
| 33 | Stalled developmental programs at the root of pediatric brain tumors | Nature Genetics | 2019 | 136 |
| 34 | Treatment of Lysosomal Storage Disorders | Drugs | 2007 | 133 |
| 35 | Effect of nitisinone (NTBC) treatment on the clinical course of hepatorenal tyrosinemia in Québec | Molecular Genetics and Metabolism | 2012 | 132 |
| 36 | The dentate nucleus in Friedreich’s ataxia: the role of iron-responsive proteins | Acta Neuropathologica | 2007 | 130 |
| 37 | A Randomized, Controlled Trial of Bedside Versus Conference-Room Case Presentation in a Pediatric Intensive Care Unit | Pediatrics | 2007 | 124 |
| 38 | Recent developments in childhood arterial ischaemic stroke | Lancet Neurology, The | 2008 | 123 |
| 39 | Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study | Canadian Journal of Anaesthesia | 2015 | 123 |
| 40 | Mutations in C5ORF42 Cause Joubert Syndrome in the French Canadian Population | American Journal of Human Genetics | 2012 | 118 |
| 41 | A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome | Cell Reports | 2015 | 113 |
| 42 | Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia | Cerebellum | 2006 | 109 |
| 43 | Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma | Neuro-Oncology | 2014 | 108 |
| 44 | Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas | Nuclear Medicine Communications | 2007 | 107 |
| 45 | Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in malignant brain tumors | Cancer | 2005 | 106 |
| 46 | Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long‐term effects on recurrence and mortality: A randomized trial among head and neck cancer patients | International Journal of Cancer | 2008 | 106 |
| 47 | Off-pump coronary artery bypass surgery: physiology and anaesthetic management † | British Journal of Anaesthesia | 2004 | 104 |
| 48 | Lower Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased Insulin Resistance and Higher Risk of Developing Gestational Diabetes Mellitus | Diabetes Care | 2013 | 102 |
| 49 | Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas | Pituitary | 2009 | 101 |
| 50 | The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: Anemia, Biomarkers, and Recent Therapeutic Trial Implications | Canadian Journal of Cardiology | 2015 | 96 |
