| # | Title | Journal | Year | Citations |
|---|
| 1 | Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer | New England Journal of Medicine | 2008 | 3,112 |
| 2 | Mechanisms linking obesity with cardiovascular disease | Nature | 2006 | 2,269 |
| 3 | FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2015 | 2,188 |
| 4 | The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer | Cell Proliferation | 2003 | 1,348 |
| 5 | The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease | BioMed Research International | 2017 | 1,089 |
| 6 | Incapacitating Unilateral Tinnitus in Single-Sided Deafness Treated by Cochlear Implantation | Annals of Otology, Rhinology and Laryngology | 2008 | 1,046 |
| 7 | Changing patterns in the epidemiology of traumatic brain injury | Nature Reviews Neurology | 2013 | 1,036 |
| 8 | Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study | Lancet, The | 2011 | 938 |
| 9 | Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study | Lancet, The | 2009 | 931 |
| 10 | Early prognosis in traumatic brain injury: from prophecies to predictions | Lancet Neurology, The | 2010 | 911 |
| 11 | Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening | Gastroenterology | 2016 | 847 |
| 12 | Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease | Journal of Crohn's and Colitis | 2014 | 804 |
| 13 | Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study | Lancet, The | 2006 | 722 |
| 14 | Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone) | Pain Practice | 2008 | 710 |
| 15 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 16 | Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation | European Journal of Cancer | 1996 | 663 |
| 17 | Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials | Annals of Oncology | 2017 | 654 |
| 18 | Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer | European Journal of Cardio-thoracic Surgery | 2014 | 638 |
| 19 | Clinical Recommendations for Cardiopulmonary Exercise Testing Data Assessment in Specific Patient Populations | Circulation | 2012 | 596 |
| 20 | Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation | European Journal of Heart Failure | 2011 | 580 |
| 21 | Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human | Nature | 2012 | 572 |
| 22 | Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management | European Respiratory Journal | 2016 | 572 |
| 23 | Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide | International Journal of Obesity | 2012 | 532 |
| 24 | The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer | Journal of Thoracic Oncology | 2016 | 530 |
| 25 | A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis | Hepatology | 2018 | 528 |
| 26 | Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis | American Journal of Gastroenterology | 2017 | 524 |
| 27 | Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis | PLoS Medicine | 2014 | 507 |
| 28 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 503 |
| 29 | 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial | Lancet, The | 2017 | 502 |
| 30 | TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease | Nature Communications | 2014 | 478 |
| 31 | An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis | Lancet Oncology, The | 2009 | 477 |
| 32 | Nosology and classification of genetic skeletal disorders: 2015 revision | American Journal of Medical Genetics, Part A | 2015 | 453 |
| 33 | European Society for Swallowing Disorders – European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome | Clinical Interventions in Aging | 2016 | 445 |
| 34 | Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells | Blood | 2001 | 438 |
| 35 | The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015 | Journal of Thoracic Oncology | 2022 | 429 |
| 36 | Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice | Oxidative Medicine and Cellular Longevity | 2016 | 428 |
| 37 | De novo mutations of SETBP1 cause Schinzel-Giedion syndrome | Nature Genetics | 2010 | 417 |
| 38 | Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial | Lancet Oncology, The | 2017 | 415 |
| 39 | 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up | Annals of Oncology | 2014 | 410 |
| 40 | Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial | Lancet Oncology, The | 2010 | 407 |
| 41 | Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial | Lancet Oncology, The | 2013 | 402 |
| 42 | Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial | Lancet, The | 2010 | 400 |
| 43 | Intrathoracic Impedance Monitoring, Audible Patient Alerts, and Outcome in Patients With Heart Failure | Circulation | 2011 | 392 |
| 44 | Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm | Nature Genetics | 2012 | 391 |
| 45 | Cell cycle and apoptosis | Cell Proliferation | 2003 | 385 |
| 46 | Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications | Journal of Hepatology | 2016 | 366 |
| 47 | Determinants and Prognostic Implications of Persistent ST-Segment Elevation After Primary Angioplasty for Acute Myocardial Infarction | Circulation | 1999 | 360 |
| 48 | Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial | Lancet Oncology, The | 2015 | 358 |
| 49 | Acute Biomarkers of Traumatic Brain Injury: Relationship between Plasma Levels of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein | Journal of Neurotrauma | 2014 | 356 |
| 50 | The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposal for an Evidence-Based Stage Classification System for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors | Journal of Thoracic Oncology | 2014 | 352 |
