| # | Title | Journal | Year | Citations |
|---|
| 1 | Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq | Nature | 2012 | 3,661 |
| 2 | A single ataxia telangiectasia gene with a product similar to PI-3 kinase | Science | 1995 | 2,634 |
| 3 | Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors | Biochemical Pharmacology | 1995 | 2,561 |
| 4 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 5 | Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys | British Journal of Psychiatry | 2010 | 1,854 |
| 6 | Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study | Journal of Clinical Oncology | 2020 | 1,740 |
| 7 | Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients | Arthritis and Rheumatism | 2002 | 1,736 |
| 8 | Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer | New England Journal of Medicine | 2019 | 1,582 |
| 9 | Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community | Arthritis and Rheumatism | 1993 | 1,477 |
| 10 | Gene expression regulation mediated through reversible m6A RNA methylation | Nature Reviews Genetics | 2014 | 1,401 |
| 11 | Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study | Lancet Oncology, The | 2020 | 1,363 |
| 12 | Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer | JAMA Oncology | 2018 | 1,350 |
| 13 | Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders | Journal of Crohn's and Colitis | 2017 | 1,324 |
| 14 | Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombotic Events in Patients With Acute Myocardial Infarction | Circulation | 2004 | 1,274 |
| 15 | Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial | Lancet Oncology, The | 2014 | 1,237 |
| 16 | ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making | Annals of Oncology | 2012 | 1,233 |
| 17 | Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium | Circulation | 2003 | 1,115 |
| 18 | The human tumor microbiome is composed of tumor type–specific intracellular bacteria | Science | 2020 | 1,077 |
| 19 | Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine | Science | 2017 | 1,059 |
| 20 | Dependence on REM sleep of overnight improvement of a perceptual skill | Science | 1994 | 1,049 |
| 21 | Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) | Lancet, The | 2017 | 1,032 |
| 22 | European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update | European Urology | 2019 | 1,022 |
| 23 | Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial | Lancet Oncology, The | 2016 | 943 |
| 24 | MicroRNAs accurately identify cancer tissue origin | Nature Biotechnology | 2008 | 909 |
| 25 | Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack | Immunity | 2015 | 900 |
| 26 | 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) | Annals of Oncology | 2018 | 891 |
| 27 | Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management | Journal of Crohn's and Colitis | 2017 | 876 |
| 28 | Tumors of the Brain and Nervous System after Radiotherapy in Childhood | New England Journal of Medicine | 1988 | 869 |
| 29 | Immunosuppressive therapy in lupus nephritis: The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide | Arthritis and Rheumatism | 2002 | 849 |
| 30 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 31 | Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease | Journal of Crohn's and Colitis | 2014 | 804 |
| 32 | Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients | Science | 2021 | 784 |
| 33 | Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient | PLoS Medicine | 2009 | 780 |
| 34 | Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats | Nature Medicine | 1998 | 769 |
| 35 | The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA | Nature | 2016 | 765 |
| 36 | 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) | Annals of Oncology | 2020 | 761 |
| 37 | Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines | Lupus | 2003 | 757 |
| 38 | Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2–Positive, Hormone Receptor–Positive Metastatic Breast Cancer: Results From the Randomized Phase III TAnDEM Study | Journal of Clinical Oncology | 2009 | 746 |
| 39 | A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses | Breast Cancer Research and Treatment | 2008 | 732 |
| 40 | Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia | Nature Medicine | 2000 | 727 |
| 41 | Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas | Clinical Endocrinology | 2006 | 720 |
| 42 | Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology Consortium | Cancer | 2008 | 716 |
| 43 | Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Added to Ongoing Metformin Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Alone | Diabetes Care | 2006 | 700 |
| 44 | Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways | Chemical Reviews | 2012 | 694 |
| 45 | Substitution of three amino acids switches receptor specificity of Gqα to that of Giα | Nature | 1993 | 693 |
| 46 | Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood | New England Journal of Medicine | 2016 | 683 |
| 47 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2015 | 678 |
| 48 | EULAR recommendations for the management of antiphospholipid syndrome in adults | Annals of the Rheumatic Diseases | 2019 | 664 |
| 49 | Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—A review of recent evidence | Autoimmunity Reviews | 2013 | 655 |
| 50 | European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage | International Journal of Stroke | 2014 | 638 |
