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Top Articles

#TitleJournalYearCitations
1The PRISMA 2020 statement: an updated guideline for reporting systematic reviewsBMJ, The202126,066
2NIA‐AA Research Framework: Toward a biological definition of Alzheimer's diseaseAlzheimer's and Dementia20185,861
3Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer's and Dementia20115,550
4Alzheimer's Disease: Genes, Proteins, and TherapyPhysiological Reviews20015,475
5Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast CarcinomaNew England Journal of Medicine19915,222
6Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersNature Cell Biology20084,285
7Host–microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseNature20124,038
8Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivoNature20023,979
9Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial arteryJournal of the American College of Cardiology20023,941
10Global variation in copy number in the human genomeNature20063,831
11The PRISMA 2020 statement: an updated guideline for reporting systematic reviewsSystematic Reviews20213,624
12Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience19993,619
13Fast, sensitive and accurate integration of single-cell data with HarmonyNature Methods20193,494
14The PRISMA 2020 statement: An updated guideline for reporting systematic reviewsInternational Journal of Surgery20213,487
15PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviewsBMJ, The20213,413
16Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approachNature Communications20143,355
17Biological, clinical and population relevance of 95 loci for blood lipidsNature20103,249
18Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,122
19Mesenchymal stem cells within tumour stroma promote breast cancer metastasisNature20072,874
20Somatic mutations affect key pathways in lung adenocarcinomaNature20082,694
21Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteriaLancet Neurology, The20142,657
22Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence or absence of asynergyAmerican Journal of Cardiology19762,477
23Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectinsScience19892,274
24Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressionNature Genetics20182,224
25Inflammasome-activated gasdermin D causes pyroptosis by forming membrane poresNature20162,143
26An immunogenic personal neoantigen vaccine for patients with melanomaNature20172,112
27Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy MenCirculation20002,111
28Dissecting racial bias in an algorithm used to manage the health of populationsScience20192,111
29Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICUCritical Care Medicine20182,074
30Identification of a unique TGF-β–dependent molecular and functional signature in microgliaNature Neuroscience20142,056
31Epigenetic memory in induced pluripotent stem cellsNature20102,011
32Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionJournal of Experimental Medicine20072,000
33Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional CoactivatorsCell20061,948
34Extracellular DNA traps promote thrombosisProceedings of the National Academy of Sciences of the United States of America20101,940
35Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitorsScience20171,846
36Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory SitesScience20091,806
37A? Oligomers ? a decade of discoveryJournal of Neurochemistry20071,795
38Hundreds of variants clustered in genomic loci and biological pathways affect human heightNature20101,789
39Landscape of somatic mutations in 560 breast cancer whole-genome sequencesNature20161,760
40Role of Endothelial Dysfunction in AtherosclerosisCirculation20041,757
41The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative DiseasesImmunity20171,741
42Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein productionNature19921,732
43BoneJ: Free and extensible bone image analysis in ImageJBone20101,695
44Genetic and epigenetic fine mapping of causal autoimmune disease variantsNature20151,669
45CD4+CD25high Regulatory Cells in Human Peripheral BloodJournal of Immunology20011,655
46IL-21 initiates an alternative pathway to induce proinflammatory TH17 cellsNature20071,650
47Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple SclerosisJournal of Experimental Medicine20041,608
48AtherosclerosisNature Reviews Disease Primers20191,601
49Natural oligomers of the amyloid-β protein specifically disrupt cognitive functionNature Neuroscience20051,595
50Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care UnitsNew England Journal of Medicine20041,589