# | Title | Journal | Year | Citations |
---|
1 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | BMJ, The | 2021 | 26,066 |
2 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
3 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
4 | Alzheimer's Disease: Genes, Proteins, and Therapy | Physiological Reviews | 2001 | 5,475 |
5 | Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma | New England Journal of Medicine | 1991 | 5,222 |
6 | Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Nature Cell Biology | 2008 | 4,285 |
7 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
8 | Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo | Nature | 2002 | 3,979 |
9 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery | Journal of the American College of Cardiology | 2002 | 3,941 |
10 | Global variation in copy number in the human genome | Nature | 2006 | 3,831 |
11 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | Systematic Reviews | 2021 | 3,624 |
12 | Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE | Science | 1999 | 3,619 |
13 | Fast, sensitive and accurate integration of single-cell data with Harmony | Nature Methods | 2019 | 3,494 |
14 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | International Journal of Surgery | 2021 | 3,487 |
15 | PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews | BMJ, The | 2021 | 3,413 |
16 | Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach | Nature Communications | 2014 | 3,355 |
17 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
18 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
19 | Mesenchymal stem cells within tumour stroma promote breast cancer metastasis | Nature | 2007 | 2,874 |
20 | Somatic mutations affect key pathways in lung adenocarcinoma | Nature | 2008 | 2,694 |
21 | Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria | Lancet Neurology, The | 2014 | 2,657 |
22 | Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence or absence of asynergy | American Journal of Cardiology | 1976 | 2,477 |
23 | Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins | Science | 1989 | 2,274 |
24 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
25 | Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores | Nature | 2016 | 2,143 |
26 | An immunogenic personal neoantigen vaccine for patients with melanoma | Nature | 2017 | 2,112 |
27 | Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men | Circulation | 2000 | 2,111 |
28 | Dissecting racial bias in an algorithm used to manage the health of populations | Science | 2019 | 2,111 |
29 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
30 | Identification of a unique TGF-β–dependent molecular and functional signature in microglia | Nature Neuroscience | 2014 | 2,056 |
31 | Epigenetic memory in induced pluripotent stem cells | Nature | 2010 | 2,011 |
32 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression | Journal of Experimental Medicine | 2007 | 2,000 |
33 | Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators | Cell | 2006 | 1,948 |
34 | Extracellular DNA traps promote thrombosis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,940 |
35 | Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors | Science | 2017 | 1,846 |
36 | Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites | Science | 2009 | 1,806 |
37 | A? Oligomers ? a decade of discovery | Journal of Neurochemistry | 2007 | 1,795 |
38 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
39 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
40 | Role of Endothelial Dysfunction in Atherosclerosis | Circulation | 2004 | 1,757 |
41 | The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases | Immunity | 2017 | 1,741 |
42 | Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production | Nature | 1992 | 1,732 |
43 | BoneJ: Free and extensible bone image analysis in ImageJ | Bone | 2010 | 1,695 |
44 | Genetic and epigenetic fine mapping of causal autoimmune disease variants | Nature | 2015 | 1,669 |
45 | CD4+CD25high Regulatory Cells in Human Peripheral Blood | Journal of Immunology | 2001 | 1,655 |
46 | IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells | Nature | 2007 | 1,650 |
47 | Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis | Journal of Experimental Medicine | 2004 | 1,608 |
48 | Atherosclerosis | Nature Reviews Disease Primers | 2019 | 1,601 |
49 | Natural oligomers of the amyloid-β protein specifically disrupt cognitive function | Nature Neuroscience | 2005 | 1,595 |
50 | Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care Units | New England Journal of Medicine | 2004 | 1,589 |