| # | Title | Journal | Year | Citations |
|---|
| 1 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,688 |
| 2 | Incidence and Mortality of Hip Fractures in the United States | JAMA - Journal of the American Medical Association | 2009 | 1,248 |
| 3 | Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations | Pediatrics | 2008 | 1,106 |
| 4 | Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED | JAMA - Journal of the American Medical Association | 2016 | 628 |
| 5 | Epidemiology of Postconcussion Syndrome in Pediatric Mild Traumatic Brain Injury | Pediatrics | 2010 | 536 |
| 6 | Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group | Epilepsia Open | 2018 | 412 |
| 7 | Revascularization and Aneurysm Surgery: Current Techniques, Indications, and Outcome | Neurosurgery | 1996 | 397 |
| 8 | Anakinra as first‐line disease‐modifying therapy in systemic juvenile idiopathic arthritis: Report of forty‐six patients from an international multicenter series | Arthritis and Rheumatism | 2011 | 397 |
| 9 | Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors | Neurology | 2017 | 384 |
| 10 | Psychometric Properties of the Revised Developmental Coordination Disorder Questionnaire | Physical and Occupational Therapy in Pediatrics | 2009 | 372 |
| 11 | Partial leptin deficiency and human adiposity | Nature | 2001 | 356 |
| 12 | Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research | Biology of Blood and Marrow Transplantation | 2015 | 331 |
| 13 | T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates | Nature Medicine | 1998 | 321 |
| 14 | Mutations in the gene encoding immunoglobulin μ-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1 | Nature Genetics | 2001 | 317 |
| 15 | Late Neurologic and Cognitive Sequelae of Inflicted Traumatic Brain Injury in Infancy | Pediatrics | 2005 | 292 |
| 16 | Three Linked Vasculopathic Processes Characterize Kawasaki Disease: A Light and Transmission Electron Microscopic Study | PLoS ONE | 2012 | 284 |
| 17 | Choroid plexus tumours | British Journal of Cancer | 2002 | 278 |
| 18 | Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects | Journal of Pediatrics | 2002 | 278 |
| 19 | Motor and gestural performance in children with autism spectrum disorders, developmental coordination disorder, and/or attention deficit hyperactivity disorder | Journal of the International Neuropsychological Society | 2007 | 278 |
| 20 | Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders | Journal of Allergy and Clinical Immunology | 2017 | 261 |
| 21 | Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture | Nature Genetics | 2010 | 259 |
| 22 | Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents | JAMA - Journal of the American Medical Association | 2016 | 250 |
| 23 | Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS | Bone Marrow Transplantation | 2012 | 245 |
| 24 | GJA1mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype | Human Mutation | 2009 | 240 |
| 25 | Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 235 |
| 26 | Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus | Nature Genetics | 2012 | 234 |
| 27 | Reporting guidelines for health care simulation research: extensions to the CONSORT and STROBE statements | Advances in Simulation | 2016 | 233 |
| 28 | Epidemiology of Sporadic Diarrhea Due to Verocytotoxin-Producing Escherichia coli: A Two-Year Prospective Study | Journal of Infectious Diseases | 1988 | 232 |
| 29 | Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty‐eight patients | Arthritis and Rheumatism | 2009 | 231 |
| 30 | Telemedicine approach to screening for severe retinopathy of prematurity | Ophthalmology | 2003 | 225 |
| 31 | Symptomatic Neonatal Arterial Ischemic Stroke: The International Pediatric Stroke Study | Pediatrics | 2011 | 225 |
| 32 | Permanent consequences in Langerhans cell histiocytosis patients: A pilot study from the Histiocyte Society?Late Effects Study Group | Pediatric Blood and Cancer | 2004 | 224 |
| 33 | The chromosome constitution of 1000 human spermatozoa | Human Genetics | 1983 | 223 |
| 34 | Impact of Growth Hormone Supplementation on Adult Height in Turner Syndrome: Results of the Canadian Randomized Controlled Trial | Journal of Clinical Endocrinology and Metabolism | 2005 | 220 |
| 35 | Invasive Group A Streptococcal Disease in Children and Association With Varicella-Zoster Virus Infection | Pediatrics | 2000 | 217 |
| 36 | Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal) as a Rescue Agent for Severe Refractory Acute Graft-versus-Host Disease in Pediatric Patients | Biology of Blood and Marrow Transplantation | 2014 | 214 |
| 37 | Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry | Pediatric Neurology | 2017 | 213 |
| 38 | Parenting in adults with attention-deficit/hyperactivity disorder (ADHD) | Clinical Psychology Review | 2012 | 207 |
| 39 | Presumed perinatal ischemic stroke: Vascular classification predicts outcomes | Annals of Neurology | 2008 | 206 |
| 40 | Genotypic and Phenotypic Spectrum in Tricho-Rhino-Phalangeal Syndrome Types I and III | American Journal of Human Genetics | 2001 | 205 |
| 41 | Tissue-specific roles of IRS proteins in insulin signaling and glucose transport | Trends in Endocrinology and Metabolism | 2006 | 205 |
| 42 | Two distinct pathways for developmental coordination disorder: Persistence and resolution | Human Movement Science | 2003 | 202 |
| 43 | Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients | American Journal of Medical Genetics, Part A | 2007 | 201 |
| 44 | Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition | Journal of Medical Genetics | 2005 | 199 |
| 45 | Shiga Toxin–ProducingEscherichia coliInfection, Antibiotics, and Risk of Developing Hemolytic Uremic Syndrome: A Meta-analysis | Clinical Infectious Diseases | 2016 | 194 |
| 46 | Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men | Reproduction | 2001 | 191 |
| 47 | Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors | Cancer Cell | 2016 | 191 |
| 48 | Central nervous system atypical teratoid rhabdoid tumours: The Canadian Paediatric Brain Tumour Consortium experience | European Journal of Cancer | 2012 | 186 |
| 49 | Distribution of aneuploidy in human gametes: Comparison between human sperm and oocytes | American Journal of Medical Genetics Part A | 1991 | 185 |
| 50 | Improving Cardiopulmonary Resuscitation With a CPR Feedback Device and Refresher Simulations (CPR CARES Study) | JAMA Pediatrics | 2015 | 185 |
