| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 3 | Growth of Large-Area and Highly Crystalline MoS2 Thin Layers on Insulating Substrates | Nano Letters | 2012 | 1,749 |
| 4 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | A broadband achromatic metalens in the visible | Nature Nanotechnology | 2018 | 1,146 |
| 7 | The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria | Journal of the European Academy of Dermatology and Venereology | 2014 | 977 |
| 8 | Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota | Nature Communications | 2015 | 926 |
| 9 | Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics | Clinica Chimica Acta | 2004 | 824 |
| 10 | SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses | Cell | 2022 | 788 |
| 11 | Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis | Science | 2007 | 731 |
| 12 | MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis | Journal of Clinical Investigation | 2012 | 726 |
| 13 | <p>Taiwan’s National Health Insurance Research Database: past and future</p> | Clinical Epidemiology | 2019 | 715 |
| 14 | Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA) | Annals of the Rheumatic Diseases | 2014 | 659 |
| 15 | Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis | Nature Medicine | 2008 | 653 |
| 16 | Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma | Cancer Discovery | 2017 | 637 |
| 17 | NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review | Frontiers in Molecular Neuroscience | 2015 | 616 |
| 18 | Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B | Hepatology | 2002 | 600 |
| 19 | Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma ≤4 cm | Gastroenterology | 2004 | 600 |
| 20 | Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions | Pharmacogenetics and Genomics | 2006 | 583 |
| 21 | The development of cirrhosis in patients with chronic type B hepatitis: A prospective study | Hepatology | 1988 | 568 |
| 22 | COVID-19: The first documented coronavirus pandemic in history | Biomedical Journal | 2020 | 545 |
| 23 | Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy | Hepatology | 1999 | 535 |
| 24 | Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less | Gut | 2005 | 526 |
| 25 | Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis | Gut | 2019 | 524 |
| 26 | The Novel Coronavirus 2019 epidemic and kidneys | Kidney International | 2020 | 502 |
| 27 | The simultaneous electrochemical detection of ascorbic acid, dopamine, and uric acid using graphene/size-selected Pt nanocomposites | Biosensors and Bioelectronics | 2011 | 488 |
| 28 | Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes | Cardiovascular Research | 2000 | 463 |
| 29 | Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome | Nature Biotechnology | 2012 | 461 |
| 30 | Catastrophic payments for health care in Asia | Health Economics (United Kingdom) | 2007 | 459 |
| 31 | Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease | JAMA Neurology | 2017 | 454 |
| 32 | Does Universal Health Insurance Make Health Care Unaffordable? Lessons From Taiwan | Health Affairs | 2003 | 451 |
| 33 | Tissue macrophages: heterogeneity and functions | BMC Biology | 2017 | 448 |
| 34 | Electrospun collagen/chitosan nanofibrous membrane as wound dressing | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2008 | 438 |
| 35 | Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC) | European Journal of Pharmaceutics and Biopharmaceutics | 2008 | 433 |
| 36 | Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage | Mitochondrion | 2007 | 426 |
| 37 | A Comprehensive Review on Current Advances in Peptide Drug Development and Design | International Journal of Molecular Sciences | 2019 | 413 |
| 38 | Oxidative stress caused by mitochondrial calcium overload | Annals of the New York Academy of Sciences | 2010 | 411 |
| 39 | Degradation of methylene blue and methyl orange by palladium-doped TiO2 photocatalysis for water reuse: Efficiency and degradation pathways | Journal of Cleaner Production | 2018 | 403 |
| 40 | p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease | Nephrology Dialysis Transplantation | 2011 | 390 |
| 41 | The Neural System Underlying Chinese Logograph Reading | NeuroImage | 2001 | 387 |
| 42 | Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease | Lancet, The | 1999 | 386 |
| 43 | Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms | Nature | 2009 | 380 |
| 44 | Updates of pathologic myopia | Progress in Retinal and Eye Research | 2016 | 380 |
| 45 | A Clinicopathologic Study of 79 Cases with an Analysis of Histologic Subtypes, Immunohistology, and DNA Ploidy | American Journal of Surgical Pathology | 1995 | 379 |
| 46 | Risk Factors of Pneumothorax and Bleeding | Chest | 2004 | 379 |
| 47 | Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases | JAMA Oncology | 2017 | 376 |
| 48 | Comparative analysis of MCDM methods for ranking renewable energy sources in Taiwan | Renewable and Sustainable Energy Reviews | 2018 | 375 |
| 49 | Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes | Nature Medicine | 2020 | 372 |
| 50 | Do miniscrews remain stationary under orthodontic forces? | American Journal of Orthodontics and Dentofacial Orthopedics | 2004 | 369 |
