| # | Title | Journal | Year | Citations |
|---|
| 1 | Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene | Separation and Purification Technology | 1998 | 6,776 |
| 2 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,625 |
| 3 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 6,567 |
| 4 | Specific association of human telomerase activity with immortal cells and cancer | Science | 1994 | 6,560 |
| 5 | The nuclear receptor superfamily: The second decade | Cell | 1995 | 6,478 |
| 6 | Autophagy in the Pathogenesis of Disease | Cell | 2008 | 6,190 |
| 7 | Autophagy fights disease through cellular self-digestion | Nature | 2008 | 5,714 |
| 8 | The metabolic syndrome | Lancet, The | 2005 | 5,212 |
| 9 | Regulation of the mevalonate pathway | Nature | 1990 | 4,996 |
| 10 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior | Cell | 1998 | 4,993 |
| 11 | Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked | Science | 1997 | 4,648 |
| 12 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 4,468 |
| 13 | Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report | American Journal of Psychiatry | 2006 | 4,241 |
| 14 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 15 | Biomolecular condensates: organizers of cellular biochemistry | Nature Reviews Molecular Cell Biology | 2017 | 3,771 |
| 16 | Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials | Lancet, The | 2003 | 3,757 |
| 17 | Interactions Between the Microbiota and the Immune System | Science | 2012 | 3,422 |
| 18 | The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor | Cell | 1997 | 3,353 |
| 19 | Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions* | Endocrine Reviews | 2001 | 3,352 |
| 20 | The landscape of somatic copy-number alteration across human cancers | Nature | 2010 | 3,331 |
| 21 | Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway | Science | 2013 | 3,305 |
| 22 | Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors | Cell | 1998 | 3,278 |
| 23 | Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity | Hepatology | 2004 | 3,250 |
| 24 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy | Cell | 2005 | 3,204 |
| 25 | Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition | Cell | 2000 | 3,149 |
| 26 | The Consensus Coding Sequences of Human Breast and Colorectal Cancers | Science | 2006 | 3,130 |
| 27 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 28 | Autophagy and Viruses: Adversaries or Allies? | Journal of Innate Immunity | 2013 | 3,100 |
| 29 | Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases | Hepatology | 2018 | 3,096 |
| 30 | The Genomic Landscapes of Human Breast and Colorectal Cancers | Science | 2007 | 3,049 |
| 31 | The RXR heterodimers and orphan receptors | Cell | 1995 | 3,025 |
| 32 | Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus | New England Journal of Medicine | 2013 | 3,017 |
| 33 | Narcolepsy in orexin Knockout Mice | Cell | 1999 | 2,981 |
| 34 | The 16-Item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression | Biological Psychiatry | 2003 | 2,981 |
| 35 | Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 | Cell | 1997 | 2,941 |
| 36 | AASLD guidelines for the treatment of hepatocellular carcinoma | Hepatology | 2018 | 2,932 |
| 37 | Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 2,910 |
| 38 | Autophagy in immunity and inflammation | Nature | 2011 | 2,901 |
| 39 | A Neurotrophic Model for Stress-Related Mood Disorders | Biological Psychiatry | 2006 | 2,873 |
| 40 | Accurate prediction of protein structures and interactions using a three-track neural network | Science | 2021 | 2,843 |
| 41 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 | Cell | 2005 | 2,839 |
| 42 | Sequence Variations inPCSK9,Low LDL, and Protection against Coronary Heart Disease | New England Journal of Medicine | 2006 | 2,787 |
| 43 | Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease | Nature Genetics | 2008 | 2,764 |
| 44 | Hepatocellular carcinoma | Nature Reviews Disease Primers | 2021 | 2,757 |
| 45 | A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes | Cancer Cell | 2006 | 2,729 |
| 46 | Lymphocyte Homing and Homeostasis | Science | 1996 | 2,699 |
| 47 | Neurobiology of Depression | Neuron | 2002 | 2,688 |
| 48 | National Sleep Foundation’s sleep time duration recommendations: methodology and results summary | Sleep Health | 2015 | 2,675 |
| 49 | Functional Classification and Experimental Dissection of Long Noncoding RNAs | Cell | 2018 | 2,657 |
| 50 | A single ataxia telangiectasia gene with a product similar to PI-3 kinase | Science | 1995 | 2,634 |
