| # | Title | Journal | Year | Citations |
|---|
| 1 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,060 |
| 2 | Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes | New England Journal of Medicine | 2008 | 6,447 |
| 3 | Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group | Clinical Infectious Diseases | 2008 | 4,375 |
| 4 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 5 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 6 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 8 | Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments | Brain Pathology | 2009 | 2,884 |
| 9 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 10 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 11 | Collective cell migration in morphogenesis, regeneration and cancer | Nature Reviews Molecular Cell Biology | 2009 | 2,170 |
| 12 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 13 | Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial | Lancet Oncology, The | 2015 | 1,861 |
| 14 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 15 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 16 | Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2012 | 1,752 |
| 17 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 18 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update | Annals of the Rheumatic Diseases | 2014 | 1,688 |
| 19 | Cancer Invasion and the Microenvironment: Plasticity and Reciprocity | Cell | 2011 | 1,669 |
| 20 | How should we define health? | BMJ: British Medical Journal | 2011 | 1,632 |
| 21 | Large recurrent microdeletions associated with schizophrenia | Nature | 2008 | 1,619 |
| 22 | Classification of Intrinsically Disordered Regions and Proteins | Chemical Reviews | 2014 | 1,618 |
| 23 | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | Nature Genetics | 2019 | 1,594 |
| 24 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,572 |
| 25 | Nitrite-driven anaerobic methane oxidation by oxygenic bacteria | Nature | 2010 | 1,521 |
| 26 | Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial | Lancet Oncology, The | 2011 | 1,508 |
| 27 | Phaeochromocytoma | Lancet, The | 2005 | 1,462 |
| 28 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 29 | A variant associated with nicotine dependence, lung cancer and peripheral arterial disease | Nature | 2008 | 1,399 |
| 30 | BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams | BMC Genomics | 2008 | 1,371 |
| 31 | Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial | Lancet Oncology, The | 2014 | 1,356 |
| 32 | Patient safety, satisfaction, and quality of hospital care: cross sectional surveys of nurses and patients in 12 countries in Europe and the United States | BMJ: British Medical Journal | 2012 | 1,321 |
| 33 | Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control | Biological Psychiatry | 2011 | 1,315 |
| 34 | Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 1,294 |
| 35 | Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2014 | 1,280 |
| 36 | Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer | European Urology | 2017 | 1,241 |
| 37 | Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2008 | 1,239 |
| 38 | Parkinson's disease | Lancet, The | 2021 | 1,176 |
| 39 | A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants | Nature Genetics | 2016 | 1,167 |
| 40 | European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines | European Urology | 2021 | 1,152 |
| 41 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 42 | FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2010 | 1,147 |
| 43 | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics | 2010 | 1,132 |
| 44 | YASARA View—molecular graphics for all devices—from smartphones to workstations | Bioinformatics | 2014 | 1,128 |
| 45 | Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force | Journal of Cell Biology | 2013 | 1,123 |
| 46 | Improving physical realism, stereochemistry, and side‐chain accuracy in homology modeling: Four approaches that performed well in CASP8 | Proteins: Structure, Function and Bioinformatics | 2009 | 1,105 |
| 47 | Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study | Lancet Oncology, The | 2015 | 1,100 |
| 48 | 2016 updated EULAR evidence-based recommendations for the management of gout | Annals of the Rheumatic Diseases | 2017 | 1,096 |
| 49 | Deciphering the evolution and metabolism of an anammox bacterium from a community genome | Nature | 2006 | 1,075 |
| 50 | Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 | Nature Biotechnology | 2007 | 1,047 |
