| # | Title | Journal | Year | Citations |
|---|
| 1 | MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia | Nature Genetics | 2002 | 1,720 |
| 2 | Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia | Nature Genetics | 2003 | 960 |
| 3 | 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease | Lancet, The | 1999 | 924 |
| 4 | Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease | Journal of Crohn's and Colitis | 2014 | 804 |
| 5 | Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting | European Journal of Endocrinology | 2017 | 771 |
| 6 | Pompe's disease | Lancet, The | 2008 | 669 |
| 7 | Immunophenotyping of blood lymphocytes in childhoodReference values for lymphocyte subpopulations | Journal of Pediatrics | 1997 | 661 |
| 8 | Complementary Feeding | Journal of Pediatric Gastroenterology and Nutrition | 2017 | 644 |
| 9 | Survey of unlicensed and off label drug use in paediatric wards in European countries | BMJ: British Medical Journal | 2000 | 622 |
| 10 | Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients | Lancet, The | 2001 | 580 |
| 11 | Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management | European Respiratory Journal | 2016 | 572 |
| 12 | Gene-Expression Patterns in Drug-Resistant Acute Lymphoblastic Leukemia Cells and Response to Treatment | New England Journal of Medicine | 2004 | 565 |
| 13 | The MLL recombinome of acute leukemias in 2017 | Leukemia | 2018 | 527 |
| 14 | The Prevalence of DSM-III-R Diagnoses in a National Sample of Dutch Adolescents | Archives of General Psychiatry | 1997 | 480 |
| 15 | Cytochrome P450 3A | Clinical Pharmacokinetics | 1999 | 480 |
| 16 | Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance | Cancer Cell | 2006 | 475 |
| 17 | The Natural Course of Infantile Pompe's Disease: 20 Original Cases Compared With 133 Cases From the Literature | Pediatrics | 2003 | 463 |
| 18 | ESPEN guideline: Clinical nutrition in inflammatory bowel disease | Clinical Nutrition | 2017 | 457 |
| 19 | Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function | Immunity | 2014 | 455 |
| 20 | Internal and external validation of predictive models: A simulation study of bias and precision in small samples | Journal of Clinical Epidemiology | 2003 | 452 |
| 21 | Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs | The Cochrane Library | 2010 | 451 |
| 22 | Children Born Small for Gestational Age: Do They Catch Up? | Pediatric Research | 1995 | 445 |
| 23 | Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis | Science Translational Medicine | 2016 | 428 |
| 24 | HLH-94: A treatment protocol for hemophagocytic lymphohistiocytosis | Science Translational Medicine | 1997 | 417 |
| 25 | Early Dietary Intervention with a Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Allergic Manifestations and Infections during the First Two Years of Life | Journal of Nutrition | 2008 | 414 |
| 26 | Stable Prediction of Mood and Anxiety Disorders Based on Behavioral and Emotional Problems in Childhood: A 14-Year Follow-Up During Childhood, Adolescence, and Young Adulthood | American Journal of Psychiatry | 2003 | 412 |
| 27 | Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group | Epilepsia Open | 2018 | 412 |
| 28 | Bone Mineral Density in Children and Adolescents: Relation to Puberty, Calcium Intake, and Physical Activity1 | Journal of Clinical Endocrinology and Metabolism | 1997 | 391 |
| 29 | Inhibition of FLT3 in MLL | Cancer Cell | 2003 | 389 |
| 30 | New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population‐based cohort study | Ultrasound in Obstetrics and Gynecology | 2008 | 384 |
| 31 | Meta-analysis of genome-wide association studies of anxiety disorders | Molecular Psychiatry | 2016 | 373 |
| 32 | New insights to the MLL recombinome of acute leukemias | Leukemia | 2009 | 363 |
| 33 | Variation of human milk oligosaccharides in relation to milk groups and lactational periods | British Journal of Nutrition | 2010 | 361 |
| 34 | Gender Dysphoria and Gender Change in Chromosomal Females with Congenital Adrenal Hyperplasia | Archives of Sexual Behavior | 2005 | 344 |
| 35 | Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years | Journal of Allergy and Clinical Immunology | 2005 | 339 |
| 36 | Comparisons of Problems Reported by Parents of Children in 12 Cultures: Total Problems, Externalizing, and Internalizing | Journal of the American Academy of Child and Adolescent Psychiatry | 1997 | 338 |
| 37 | Titrating Steroids on Exhaled Nitric Oxide in Children with Asthma | American Journal of Respiratory and Critical Care Medicine | 2005 | 330 |
| 38 | International consensus on (ICON) pediatric asthma | Allergy: European Journal of Allergy and Clinical Immunology | 2012 | 327 |
| 39 | Recombinant human α-glucosidase from rabbit milk in Pompe patients | Lancet, The | 2000 | 321 |
| 40 | Air Pollution Exposure and Lung Function in Children: The ESCAPE Project | Environmental Health Perspectives | 2013 | 320 |
| 41 | Childhood constipation: longitudinal follow-up beyond puberty | Gastroenterology | 2003 | 318 |
| 42 | Dual-Hit Hypothesis Explains Pulmonary Hypoplasia in the Nitrofen Model of Congenital Diaphragmatic Hernia | American Journal of Pathology | 2000 | 314 |
| 43 | Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study | Lancet, The | 2003 | 306 |
| 44 | Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine | Intensive Care Medicine | 2018 | 305 |
| 45 | Systematic Review and Meta-analysis of Virtual Reality in Pediatrics: Effects on Pain and Anxiety | Anesthesia and Analgesia | 2019 | 301 |
| 46 | Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands | Leukemia | 2004 | 292 |
| 47 | Behavioral and Emotional Problems Reported by Parents of Children Ages 6 to 16 in 31 Societies | Journal of Emotional and Behavioral Disorders | 2007 | 292 |
| 48 | HOXA9 is required for survival in human MLL-rearranged acute leukemias | Blood | 2009 | 292 |
| 49 | Management of Paediatric Ulcerative Colitis, Part 1 | Journal of Pediatric Gastroenterology and Nutrition | 2018 | 292 |
| 50 | Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries | Journal of the American College of Cardiology | 2004 | 289 |
