| # | Title | Journal | Year | Citations |
|---|
| 1 | Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance | Clinical Microbiology and Infection | 2012 | 8,996 |
| 2 | Environment dominates over host genetics in shaping human gut microbiota | Nature | 2018 | 1,958 |
| 3 | Personalized Nutrition by Prediction of Glycemic Responses | Cell | 2015 | 1,816 |
| 4 | Pre-eclampsia | Lancet, The | 2005 | 1,711 |
| 5 | Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma | JAMA - Journal of the American Medical Association | 2017 | 1,619 |
| 6 | Artificial sweeteners induce glucose intolerance by altering the gut microbiota | Nature | 2014 | 1,529 |
| 7 | Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community | Arthritis and Rheumatism | 1993 | 1,477 |
| 8 | Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin | Nature | 1985 | 1,464 |
| 9 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 10 | Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer | Annals of Oncology | 2004 | 1,407 |
| 11 | Changing patterns of mortality across Europe in patients infected with HIV-1 | Lancet, The | 1998 | 1,182 |
| 12 | Increased Frequency of Genetic Thrombophilia in Women with Complications of Pregnancy | New England Journal of Medicine | 1999 | 1,012 |
| 13 | Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis | Cell | 2014 | 984 |
| 14 | Derivation of novel human ground state naive pluripotent stem cells | Nature | 2013 | 924 |
| 15 | MicroRNAs accurately identify cancer tissue origin | Nature Biotechnology | 2008 | 909 |
| 16 | Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial | Journal of Clinical Oncology | 2013 | 820 |
| 17 | Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain | NeuroImage | 2005 | 743 |
| 18 | Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner | Cell | 2019 | 718 |
| 19 | Gait and Cognition: A Complementary Approach to Understanding Brain Function and the Risk of Falling | Journal of the American Geriatrics Society | 2012 | 703 |
| 20 | Construction of freezing of gait questionnaire for patients with Parkinsonism | Parkinsonism and Related Disorders | 2000 | 669 |
| 21 | EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma | Lancet Oncology, The | 2014 | 647 |
| 22 | The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations | Journal of the American College of Cardiology | 2000 | 641 |
| 23 | The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study | Journal of the American College of Cardiology | 2001 | 611 |
| 24 | Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009 | Journal of the American Academy of Dermatology | 2010 | 610 |
| 25 | Comprehensive Analysis of Hypermutation in Human Cancer | Cell | 2017 | 596 |
| 26 | Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection | Science | 2018 | 582 |
| 27 | The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT | Journal of Nuclear Medicine | 2006 | 577 |
| 28 | Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet | Blood | 2013 | 567 |
| 29 | Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy | Nature Genetics | 2001 | 551 |
| 30 | Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia | Blood | 2021 | 539 |
| 31 | EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases | Annals of the Rheumatic Diseases | 2011 | 533 |
| 32 | Emergence of Constitutively Active Estrogen Receptor-α Mutations in Pretreated Advanced Estrogen Receptor–Positive Breast Cancer | Clinical Cancer Research | 2014 | 529 |
| 33 | J-Point Elevation in Survivors of Primary Ventricular Fibrillation and Matched Control Subjects | Journal of the American College of Cardiology | 2008 | 528 |
| 34 | Multidrug-Resistant Pseudomonas aeruginosa : Risk Factors and Clinical Impact | Antimicrobial Agents and Chemotherapy | 2006 | 527 |
| 35 | Mortality and delay in effective therapy associated with extended-spectrum -lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis | Journal of Antimicrobial Chemotherapy | 2007 | 527 |
| 36 | 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases | Annals of the Rheumatic Diseases | 2020 | 506 |
| 37 | Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study | Annals of the Rheumatic Diseases | 2021 | 503 |
| 38 | Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258 | Antimicrobial Agents and Chemotherapy | 2009 | 494 |
| 39 | New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter | Magnetic Resonance in Medicine | 2004 | 474 |
| 40 | Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study | Journal of Hepatology | 2007 | 470 |
| 41 | Gait dynamics in Parkinson’s disease: Common and distinct behavior among stride length, gait variability, and fractal-like scaling | Chaos | 2009 | 466 |
| 42 | Technology in Parkinson's disease: Challenges and opportunities | Movement Disorders | 2016 | 464 |
| 43 | Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA) | British Journal of Ophthalmology | 2014 | 463 |
| 44 | Clinical Outcome of Isolated Tricuspid Regurgitation | JACC: Cardiovascular Imaging | 2014 | 443 |
| 45 | Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex | Nature Neuroscience | 2008 | 442 |
| 46 | Predictors of Carbapenem-Resistant Klebsiella pneumoniae Acquisition among Hospitalized Adults and Effect of Acquisition on Mortality | Antimicrobial Agents and Chemotherapy | 2008 | 436 |
| 47 | The natural history of multiple system atrophy: a prospective European cohort study | Lancet Neurology, The | 2013 | 426 |
| 48 | A Multinational Survey of Risk Factors for Infection with Extended‐Spectrum β‐Lactamase–Producing Enterobacteriaceae in Nonhospitalized Patients | Clinical Infectious Diseases | 2009 | 415 |
| 49 | X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment | Nature Genetics | 2008 | 397 |
| 50 | Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study | Lancet Neurology, The | 2010 | 388 |
