| # | Title | Journal | Year | Citations |
|---|
| 1 | RoB 2: a revised tool for assessing risk of bias in randomised trials | BMJ: British Medical Journal | 2019 | 10,984 |
| 2 | Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L) | Quality of Life Research | 2011 | 5,877 |
| 3 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 4 | A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis | Nature | 2012 | 3,646 |
| 5 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | International Journal of Surgery | 2021 | 3,487 |
| 6 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 7 | Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial | Lancet, The | 2010 | 2,857 |
| 8 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 9 | Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases | European Heart Journal | 2013 | 2,436 |
| 10 | Randomised study of screening for colorectal cancer with faecal-occult-blood test | Lancet, The | 1996 | 2,327 |
| 11 | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis | Lancet Oncology, The | 2010 | 1,915 |
| 12 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 13 | Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury | Neurotoxicology and Teratology | 1997 | 1,504 |
| 14 | Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial | Lancet, The | 1999 | 1,493 |
| 15 | Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) | Lancet, The | 2000 | 1,391 |
| 16 | Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure | New England Journal of Medicine | 2016 | 1,350 |
| 17 | The Thyroid Nodule | New England Journal of Medicine | 2004 | 1,309 |
| 18 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial | Lancet, The | 2014 | 1,295 |
| 19 | Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2014 | 1,280 |
| 20 | ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making | Annals of Oncology | 2012 | 1,233 |
| 21 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 2020 | 1,209 |
| 22 | Algorithm for neuropathic pain treatment: An evidence based proposal | Pain | 2005 | 1,142 |
| 23 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 24 | Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study | Quality of Life Research | 2013 | 1,082 |
| 25 | Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡ | Human Reproduction | 2018 | 1,015 |
| 26 | European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice | Contact Dermatitis | 2015 | 1,012 |
| 27 | Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action | Pain | 1999 | 994 |
| 28 | American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules - 2016 Update Appendix | Endocrine Practice | 2016 | 990 |
| 29 | EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 979 |
| 30 | Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial | Lancet, The | 2011 | 957 |
| 31 | Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection | Journal of Infectious Diseases | 2011 | 957 |
| 32 | Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects | Journal of Physiology | 2012 | 920 |
| 33 | The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 912 |
| 34 | The evidence for pharmacological treatment of neuropathic pain | Pain | 2010 | 881 |
| 35 | Graves’ Disease | New England Journal of Medicine | 2016 | 847 |
| 36 | Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 809 |
| 37 | European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS | European Thyroid Journal | 2017 | 808 |
| 38 | A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial | Lancet, The | 2010 | 792 |
| 39 | Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study | Annals of Oncology | 2013 | 792 |
| 40 | Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Valve Stenosis | Journal of the American College of Cardiology | 2015 | 779 |
| 41 | Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study | Allergy: European Journal of Allergy and Clinical Immunology | 2011 | 778 |
| 42 | Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial | Lancet Oncology, The | 2016 | 778 |
| 43 | EFNS guidelines on pharmacological treatment of neuropathic pain | European Journal of Neurology | 2006 | 770 |
| 44 | Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration | Lancet, The | 2014 | 767 |
| 45 | Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2019 | 767 |
| 46 | Transcatheter Aortic Valve Implantation in Failed Bioprosthetic Surgical Valves | JAMA - Journal of the American Medical Association | 2014 | 762 |
| 47 | Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases | European Heart Journal | 2016 | 757 |
| 48 | Quality Indicators for Colonoscopy | American Journal of Gastroenterology | 2006 | 703 |
| 49 | EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version) | Ultraschall in Der Medizin | 2017 | 659 |
| 50 | Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark | European Heart Journal | 2014 | 653 |
