| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study | Lancet, The | 2020 | 3,119 |
| 2 | Assessment of Clinical Criteria for Sepsis | JAMA - Journal of the American Medical Association | 2016 | 2,727 |
| 3 | Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations | American Journal of Respiratory and Critical Care Medicine | 2016 | 2,385 |
| 4 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2017 | 1,388 |
| 7 | Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer | Nature Genetics | 2012 | 1,186 |
| 8 | Pain Intensity on the First Day after Surgery | Anesthesiology | 2013 | 1,117 |
| 9 | Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis | Lancet Infectious Diseases, The | 2013 | 981 |
| 10 | Sepsis and septic shock | Nature Reviews Disease Primers | 2016 | 978 |
| 11 | Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU | Critical Care Medicine | 2017 | 973 |
| 12 | Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit | Lancet Respiratory Medicine,the | 2014 | 864 |
| 13 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 14 | Cardiac Metabolism in Heart Failure | Circulation Research | 2013 | 814 |
| 15 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 16 | Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer | Science Translational Medicine | 2010 | 761 |
| 17 | Prevalence, Determinants and Patterns of Multimorbidity in Primary Care: A Systematic Review of Observational Studies | PLoS ONE | 2014 | 755 |
| 18 | Regulation of endoplasmic reticulum turnover by selective autophagy | Nature | 2015 | 714 |
| 19 | Consensus guidelines for the detection of immunogenic cell death | OncoImmunology | 2014 | 686 |
| 20 | Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy | Neuroscience and Biobehavioral Reviews | 2020 | 681 |
| 21 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 22 | The Autonomic Brain: An Activation Likelihood Estimation Meta-Analysis for Central Processing of Autonomic Function | Journal of Neuroscience | 2013 | 653 |
| 23 | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa | Nature Genetics | 2019 | 641 |
| 24 | The global burden of paediatric and neonatal sepsis: a systematic review | Lancet Respiratory Medicine,the | 2018 | 630 |
| 25 | Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state | Materials Today | 2018 | 625 |
| 26 | Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism? | NeuroImage | 2011 | 620 |
| 27 | Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations | Annals of Oncology | 2015 | 607 |
| 28 | Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2019 | 594 |
| 29 | Formation of new chromatin domains determines pathogenicity of genomic duplications | Nature | 2016 | 582 |
| 30 | Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation | Cell | 2016 | 534 |
| 31 | The MLL recombinome of acute leukemias in 2017 | Leukemia | 2018 | 527 |
| 32 | Socioeconomic Inequality and Caries | Journal of Dental Research | 2015 | 508 |
| 33 | An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models | Lancet Neurology, The | 2019 | 497 |
| 34 | Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis | Nature Genetics | 2016 | 494 |
| 35 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 36 | Efficacy and Safety of Ivacaftor in Patients Aged 6 to 11 Years with Cystic Fibrosis with a G551D Mutation | American Journal of Respiratory and Critical Care Medicine | 2013 | 449 |
| 37 | Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis | Molecular Psychiatry | 2017 | 446 |
| 38 | Effects of Antibiotics on Gut Microbiota | Digestive Diseases | 2016 | 425 |
| 39 | BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease | PLoS ONE | 2013 | 412 |
| 40 | New Approaches to Sepsis: Molecular Diagnostics and Biomarkers | Clinical Microbiology Reviews | 2012 | 408 |
| 41 | Ponatinib efficacy and safety in Philadelphia chromosome–positive leukemia: final 5-year results of the phase 2 PACE trial | Blood | 2018 | 392 |
| 42 | diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition | Nature Methods | 2020 | 387 |
| 43 | Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing | Antimicrobial Agents and Chemotherapy | 2012 | 383 |
| 44 | ICTV Virus Taxonomy Profile: Picornaviridae | Journal of General Virology | 2017 | 374 |
| 45 | Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 4-year follow-up of the phase III CheckMate 214 trial | ESMO Open | 2020 | 343 |
| 46 | Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model | Lancet Neurology, The | 2018 | 342 |
| 47 | Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis | Lancet Infectious Diseases, The | 2018 | 337 |
| 48 | Transactivation joins multiple tracks to the ERK/MAPK cascade | Nature Reviews Molecular Cell Biology | 2003 | 334 |
| 49 | The late phase of sepsis is characterized by an increased microbiological burden and death rate | Critical Care | 2011 | 334 |
| 50 | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer | Nature Genetics | 2013 | 326 |
