| # | Title | Journal | Year | Citations |
|---|
| 1 | Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials | Lancet, The | 2016 | 5,331 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Rapid and simple method for purification of nucleic acids | Journal of Clinical Microbiology | 1990 | 4,672 |
| 4 | Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis | Nature | 2010 | 4,648 |
| 5 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 6 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 7 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 8 | NF-κB: a key role in inflammatory diseases | Journal of Clinical Investigation | 2001 | 3,329 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 10 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study | Lancet, The | 2001 | 2,914 |
| 11 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 | Leukemia | 2003 | 2,788 |
| 12 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 13 | Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases | European Heart Journal | 2013 | 2,436 |
| 14 | Predicting Recurrence and Progression in Individual Patients with Stage Ta T1 Bladder Cancer Using EORTC Risk Tables: A Combined Analysis of 2596 Patients from Seven EORTC Trials | European Urology | 2006 | 2,360 |
| 15 | Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome | Gastroenterology | 2012 | 2,287 |
| 16 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 17 | Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis | Blood | 1994 | 2,012 |
| 18 | The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells | Cell | 2002 | 1,897 |
| 19 | The diagnostic odds ratio: a single indicator of test performance | Journal of Clinical Epidemiology | 2003 | 1,880 |
| 20 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support | Resuscitation | 2010 | 1,879 |
| 21 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 22 | Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis | Blood | 1994 | 1,794 |
| 23 | Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies | JAMA - Journal of the American Medical Association | 2018 | 1,783 |
| 24 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
| 25 | Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies | Stroke | 2010 | 1,729 |
| 26 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 27 | Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis | JAMA - Journal of the American Medical Association | 2016 | 1,617 |
| 28 | Genes that mediate breast cancer metastasis to the brain | Nature | 2009 | 1,587 |
| 29 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,535 |
| 30 | Clinical Features and Prognostic Factors in Adults with Bacterial Meningitis | New England Journal of Medicine | 2004 | 1,509 |
| 31 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 32 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 33 | VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy | Chest | 2012 | 1,418 |
| 34 | Tumor necrosis factor antagonist mechanisms of action: A comprehensive review | Chest | 2008 | 1,377 |
| 35 | The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome | New England Journal of Medicine | 1995 | 1,352 |
| 36 | Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate | Circulation | 2011 | 1,352 |
| 37 | Thrombosis of the Cerebral Veins and Sinuses | New England Journal of Medicine | 2005 | 1,326 |
| 38 | Routine Use of the Confusion Assessment Method for the Intensive Care Unit | American Journal of Respiratory and Critical Care Medicine | 2011 | 1,318 |
| 39 | Very high risk of cancer in familial Peutz–Jeghers syndrome | Gastroenterology | 2000 | 1,247 |
| 40 | Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial | Arthritis and Rheumatism | 2005 | 1,247 |
| 41 | Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2008 | 1,239 |
| 42 | Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis | New England Journal of Medicine | 2017 | 1,232 |
| 43 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary | Resuscitation | 2010 | 1,215 |
| 44 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 45 | HMGB1 and RAGE in Inflammation and Cancer | Annual Review of Immunology | 2010 | 1,193 |
| 46 | Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia | New England Journal of Medicine | 2008 | 1,180 |
| 47 | Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver | Cell | 2015 | 1,166 |
| 48 | Dexamethasone in Adults with Bacterial Meningitis | New England Journal of Medicine | 2002 | 1,158 |
| 49 | FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2010 | 1,147 |
| 50 | Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home | New England Journal of Medicine | 1996 | 1,108 |
