| # | Title | Journal | Year | Citations |
|---|
| 1 | WAF1, a potential mediator of p53 tumor suppression | Cell | 1993 | 8,091 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,625 |
| 4 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 5 | Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans | New England Journal of Medicine | 1996 | 5,679 |
| 6 | Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer | New England Journal of Medicine | 2010 | 5,481 |
| 7 | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure | New England Journal of Medicine | 2004 | 5,193 |
| 8 | The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents | Pediatrics | 2004 | 4,715 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 10 | Nonlinear partial differential equations and applications: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 4,641 |
| 11 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 12 | A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease | New England Journal of Medicine | 1994 | 4,014 |
| 13 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,979 |
| 14 | Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials | Lancet, The | 2014 | 3,942 |
| 15 | Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 3,753 |
| 16 | MicroRNA Gene Expression Deregulation in Human Breast Cancer | Cancer Research | 2005 | 3,719 |
| 17 | Defining the clinical course of multiple sclerosis | Neurology | 1996 | 3,352 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 19 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach | Diabetes Care | 2012 | 3,077 |
| 20 | Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial | Lancet, The | 2016 | 3,077 |
| 21 | The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After | Surgery | 2017 | 2,655 |
| 22 | The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society | Urology | 2003 | 2,597 |
| 23 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Cell Death and Differentiation | 2009 | 2,572 |
| 24 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 25 | Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression | Journal of Immunology | 2009 | 2,281 |
| 26 | Virtually Perfect? Telemedicine for Covid-19 | New England Journal of Medicine | 2020 | 2,266 |
| 27 | A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2005 | 2,255 |
| 28 | Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents | Pediatrics | 2017 | 2,199 |
| 29 | Stereotactic Body Radiation Therapy for Inoperable Early Stage Lung Cancer | JAMA - Journal of the American Medical Association | 2010 | 2,185 |
| 30 | Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Cell Death and Differentiation | 2012 | 2,144 |
| 31 | Electrospun nanofibrous structure: A novel scaffold for tissue engineering | Journal of Biomedical Materials Research Part B | 2002 | 2,134 |
| 32 | Human ICE/CED-3 Protease Nomenclature | Cell | 1996 | 2,091 |
| 33 | Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council | Journal of Pain | 2016 | 2,040 |
| 34 | Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature* | Critical Care Medicine | 2008 | 1,906 |
| 35 | Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis | Nature | 2011 | 1,831 |
| 36 | Osteoarthritis cartilage histopathology: grading and staging | Osteoarthritis and Cartilage | 2006 | 1,755 |
| 37 | Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) | Diabetologia | 2012 | 1,718 |
| 38 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 39 | Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure | JAMA - Journal of the American Medical Association | 2009 | 1,694 |
| 40 | Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,655 |
| 41 | A Randomized Trial of a Low-Carbohydrate Diet for Obesity | New England Journal of Medicine | 2003 | 1,615 |
| 42 | Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators | Circulation | 2003 | 1,610 |
| 43 | Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor | Journal of Neuroscience | 2001 | 1,563 |
| 44 | AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA | Nature | 2009 | 1,548 |
| 45 | New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society | Clinical Orthopaedics and Related Research | 2011 | 1,516 |
| 46 | Protein Modification by SUMO | Annual Review of Biochemistry | 2004 | 1,512 |
| 47 | Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy | Epilepsia | 2010 | 1,494 |
| 48 | The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated. | Archives of Physical Medicine and Rehabilitation | 2004 | 1,491 |
| 49 | Collagens: Molecular Biology, Diseases, and Potentials for Therapy | Annual Review of Biochemistry | 1995 | 1,487 |
| 50 | MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function | Annual Review of Biochemistry | 1998 | 1,473 |
