| # | Title | Journal | Year | Citations |
|---|
| 1 | The FAIR Guiding Principles for scientific data management and stewardship | Scientific Data | 2016 | 8,670 |
| 2 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2007 | 5,801 |
| 3 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,060 |
| 4 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 5 | HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis | Pediatric Blood and Cancer | 2007 | 4,018 |
| 6 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 7 | Incidence of thrombotic complications in critically ill ICU patients with COVID-19 | Thrombosis Research | 2020 | 3,872 |
| 8 | Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer | New England Journal of Medicine | 2001 | 3,840 |
| 9 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 10 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 11 | Consistent resting-state networks across healthy subjects | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 3,817 |
| 12 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | PLoS Medicine | 2007 | 3,710 |
| 13 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 14 | elastix: A Toolbox for Intensity-Based Medical Image Registration | IEEE Transactions on Medical Imaging | 2010 | 3,159 |
| 15 | Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial | Lancet, The | 2002 | 3,147 |
| 16 | Overweight, Obesity, and Depression | Archives of General Psychiatry | 2010 | 3,137 |
| 17 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 18 | ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion—Part II: shoulder, elbow, wrist and hand | Journal of Biomechanics | 2005 | 3,077 |
| 19 | 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2010 | 2,994 |
| 20 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 | Leukemia | 2003 | 2,788 |
| 21 | Rheumatoid arthritis | Lancet, The | 2010 | 2,712 |
| 22 | Toward discovery science of human brain function | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 2,703 |
| 23 | Persistent epigenetic differences associated with prenatal exposure to famine in humans | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 2,683 |
| 24 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 25 | Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study | Lancet, The | 2008 | 2,474 |
| 26 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
| 27 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 28 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 29 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 2,165 |
| 30 | Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal | BMJ, The | 2020 | 2,134 |
| 31 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 32 | An integrated map of structural variation in 2,504 human genomes | Nature | 2015 | 1,994 |
| 33 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 34 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 35 | A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains | Nature Medicine | 2000 | 1,945 |
| 36 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis | Lancet Oncology, The | 2009 | 1,920 |
| 37 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update | Annals of the Rheumatic Diseases | 2020 | 1,860 |
| 38 | Transcriptome and genome sequencing uncovers functional variation in humans | Nature | 2013 | 1,857 |
| 39 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 40 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 41 | Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2012 | 1,752 |
| 42 | Tutorial in biostatistics: competing risks and multi-state models | Statistics in Medicine | 2007 | 1,719 |
| 43 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) | Epidemiology | 2007 | 1,717 |
| 44 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration | International Journal of Surgery | 2014 | 1,698 |
| 45 | Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion | Human Mutation | 2000 | 1,688 |
| 46 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update | Annals of the Rheumatic Diseases | 2014 | 1,688 |
| 47 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 48 | The revised Ghent nosology for the Marfan syndrome | Journal of Medical Genetics | 2010 | 1,677 |
| 49 | Hypocretin (orexin) deficiency in human narcolepsy | Lancet, The | 2000 | 1,666 |
| 50 | Recommended implementation of arterial spin‐labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia | Magnetic Resonance in Medicine | 2015 | 1,663 |
