| # | Title | Journal | Year | Citations |
|---|
| 1 | NF-κB functions as a tumour promoter in inflammation-associated cancer | Nature | 2004 | 2,320 |
| 2 | Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma | New England Journal of Medicine | 2016 | 1,210 |
| 3 | The IOC consensus statement: beyond the Female Athlete Triad—Relative Energy Deficiency in Sport (RED-S) | British Journal of Sports Medicine | 2014 | 972 |
| 4 | Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness | Blood | 2005 | 966 |
| 5 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 6 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 7 | Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack | Immunity | 2015 | 900 |
| 8 | Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity | Science | 1996 | 845 |
| 9 | Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B | Hepatology | 2010 | 840 |
| 10 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 11 | Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma | Cell | 2017 | 804 |
| 12 | Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients | Science | 2021 | 784 |
| 13 | Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies | Nature Medicine | 2012 | 782 |
| 14 | A look into the nature and causes of human errors in the intensive care unit | Critical Care Medicine | 1995 | 761 |
| 15 | Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1 | Nature Genetics | 1996 | 752 |
| 16 | New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs | Cell | 2016 | 702 |
| 17 | Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer | Cell Reports | 2015 | 640 |
| 18 | Myocardial Dysfunction in Severe Sepsis and Septic Shock: More Questions Than Answers? | Journal of Cardiothoracic and Vascular Anesthesia | 2011 | 628 |
| 19 | Nurse involvement in end-of-life decision making: the ETHICUS Study | Intensive Care Medicine | 2006 | 624 |
| 20 | Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment | Fertility and Sterility | 1992 | 618 |
| 21 | Internet Addiction or Excessive Internet Use | American Journal of Drug and Alcohol Abuse | 2010 | 616 |
| 22 | Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease | Nature Genetics | 2010 | 595 |
| 23 | Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex | Fungal Genetics and Biology | 2015 | 590 |
| 24 | Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease | Nature Communications | 2018 | 584 |
| 25 | Tumour-associated neutrophils in patients with cancer | Nature Reviews Clinical Oncology | 2019 | 558 |
| 26 | Tumor-associated neutrophils: friend or foe? | Carcinogenesis | 2012 | 550 |
| 27 | Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene | Human Genetics | 2010 | 539 |
| 28 | Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity | Journal of Physiology | 2007 | 530 |
| 29 | Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc | Cell Host and Microbe | 2016 | 523 |
| 30 | Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia | Molecular Psychiatry | 1999 | 509 |
| 31 | Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis | International Journal of Biochemistry and Cell Biology | 2006 | 504 |
| 32 | Identification of tissue-specific cell death using methylation patterns of circulating DNA | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 492 |
| 33 | Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE–TIMI 58 randomised trial | Lancet Diabetes and Endocrinology,the | 2019 | 482 |
| 34 | The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy | Nature Genetics | 2001 | 476 |
| 35 | Distinctive patterns of microRNA expression in primary muscular disorders | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 458 |
| 36 | Potential roles of gut microbiome and metabolites in modulating ALS in mice | Nature | 2019 | 454 |
| 37 | 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection | American Journal of Transplantation | 2016 | 451 |
| 38 | Effects of exogenous melatonin on sleep: a meta-analysis | Sleep Medicine Reviews | 2005 | 448 |
| 39 | Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel | New England Journal of Medicine | 2021 | 445 |
| 40 | Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells | Cell Stem Cell | 2009 | 437 |
| 41 | Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery | Journal of the American College of Cardiology | 2003 | 431 |
| 42 | Loss-of-function mutations in SLC30A8 protect against type 2 diabetes | Nature Genetics | 2014 | 428 |
| 43 | A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer | Nature Genetics | 2017 | 427 |
| 44 | Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies | Bioconjugate Chemistry | 1999 | 423 |
| 45 | Biocompatibility and safety of PLA and its copolymers | Advanced Drug Delivery Reviews | 2016 | 412 |
| 46 | EULAR recommendations for the management of familial Mediterranean fever | Annals of the Rheumatic Diseases | 2016 | 393 |
| 47 | Primary prevention of peri‐implantitis: Managing peri‐implant mucositis | Journal of Clinical Periodontology | 2015 | 387 |
| 48 | Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial | Gastroenterology | 2019 | 378 |
| 49 | More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis | Chemical Senses | 2020 | 375 |
| 50 | Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis | PLoS Medicine | 2018 | 373 |
