| # | Title | Journal | Year | Citations |
|---|
| 1 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 2 | International Study of the Prevalence and Outcomes of Infection in Intensive Care Units | JAMA - Journal of the American Medical Association | 2009 | 2,682 |
| 3 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 4 | Sepsis in European intensive care units: Results of the SOAP study* | Critical Care Medicine | 2006 | 2,375 |
| 5 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 6 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis | Gastroenterology | 2013 | 2,211 |
| 7 | C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa | Chest | 2003 | 1,916 |
| 8 | Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial | Lancet Oncology, The | 2018 | 1,816 |
| 9 | A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study | Intensive Care Medicine | 2009 | 1,327 |
| 10 | Mechanisms of Pancreatic -Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities | Diabetes | 2005 | 1,296 |
| 11 | Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? | British Journal of Dermatology | 2007 | 1,257 |
| 12 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 13 | Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock* | Critical Care Medicine | 2004 | 1,185 |
| 14 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 15 | Sepsis biomarkers: a review | Critical Care | 2010 | 1,018 |
| 16 | Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2015 | 1,015 |
| 17 | Circulatory Shock | New England Journal of Medicine | 2013 | 1,012 |
| 18 | The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus | Endocrine Reviews | 2008 | 990 |
| 19 | Classification of primary and incisional abdominal wall hernias | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2009 | 915 |
| 20 | Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation | European Urology | 2010 | 905 |
| 21 | Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2017 | 831 |
| 22 | A positive fluid balance is associated with a worse outcome in patients with acute renal failure | Critical Care | 2008 | 793 |
| 23 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 24 | ESPEN expert group recommendations for action against cancer-related malnutrition | Clinical Nutrition | 2017 | 758 |
| 25 | Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD) | Movement Disorders | 1999 | 724 |
| 26 | Mild Chronic Hyponatremia Is Associated With Falls, Unsteadiness, and Attention Deficits | American Journal of Medicine | 2006 | 700 |
| 27 | The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data | Brain Imaging and Behavior | 2014 | 696 |
| 28 | Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013 | Journal of Hepatology | 2014 | 685 |
| 29 | Comparison of computed density and macroscopic morphometry in pulmonary emphysema. | American Journal of Respiratory and Critical Care Medicine | 1995 | 670 |
| 30 | Guidelines for the validation and application of typing methods for use in bacterial epidemiology | Clinical Microbiology and Infection | 2007 | 668 |
| 31 | Microcirculatory Alterations in Cardiac Surgery: Effects of Cardiopulmonary Bypass and Anesthesia | Annals of Thoracic Surgery | 2009 | 665 |
| 32 | Aristolochic acid nephropathy: A worldwide problem | Kidney International | 2008 | 637 |
| 33 | Selective amplification and cloning of four new members of the G protein-coupled receptor family | Science | 1989 | 633 |
| 34 | Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes | Journal of Allergy and Clinical Immunology | 2012 | 604 |
| 35 | Identification of common variants associated with human hippocampal and intracranial volumes | Nature Genetics | 2012 | 594 |
| 36 | Procalcitonin levels in surgical patients at risk of candidemia | Journal of Infection | 2010 | 590 |
| 37 | Sepsis definitions: time for change | Lancet, The | 2013 | 579 |
| 38 | Nosocomial infections in adult intensive-care units | Lancet, The | 2003 | 577 |
| 39 | Alterations of red blood cell shape and sialic acid membrane content in septic patients | Critical Care Medicine | 2003 | 576 |
| 40 | ESPEN guidelines on chronic intestinal failure in adults | Clinical Nutrition | 2016 | 554 |
| 41 | SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma | Nature | 2014 | 552 |
| 42 | Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure | Hepatology | 2016 | 550 |
| 43 | Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines | Journal of Crohn's and Colitis | 2013 | 541 |
| 44 | Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress | Endocrinology | 2004 | 530 |
| 45 | Facial mimicry and emotional contagion to dynamic emotional facial expressions and their influence on decoding accuracy | International Journal of Psychophysiology | 2001 | 529 |
| 46 | Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study | Journal of Neurochemistry | 1991 | 519 |
| 47 | Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study | Lancet Respiratory Medicine,the | 2020 | 516 |
| 48 | Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4 | PLoS Genetics | 2007 | 506 |
| 49 | SIROLIMUS IN ASSOCIATION WITH MYCOPHENOLATE MOFETIL INDUCTION FOR THE PREVENTION OF ACUTE GRAFT REJECTION IN RENAL ALLOGRAFT RECIPIENTS12 | Transplantation | 2000 | 499 |
| 50 | Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis | Hepatology | 2015 | 493 |
