| # | Title | Journal | Year | Citations |
|---|
| 1 | Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials | Lancet, The | 2016 | 5,331 |
| 2 | Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases | Hepatology | 2018 | 3,096 |
| 3 | Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients | Chest | 1988 | 2,298 |
| 4 | International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases | Clinical Infectious Diseases | 2011 | 2,194 |
| 5 | Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver | Journal of Biological Chemistry | 2001 | 1,829 |
| 6 | Epidemiology and risk profile of heart failure | Nature Reviews Cardiology | 2011 | 1,608 |
| 7 | Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO) | Kidney International | 2006 | 1,586 |
| 8 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,454 |
| 9 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 10 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 11 | 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee | Arthritis Care and Research | 2020 | 1,034 |
| 12 | Tadalafil Therapy for Pulmonary Arterial Hypertension | Circulation | 2009 | 956 |
| 13 | Characteristics, Treatments, and Outcomes of Patients With Preserved Systolic Function Hospitalized for Heart Failure | Journal of the American College of Cardiology | 2007 | 929 |
| 14 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 15 | 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee | Arthritis and Rheumatology | 2020 | 871 |
| 16 | Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome | Nature Genetics | 1996 | 852 |
| 17 | Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function | Journal of the American College of Cardiology | 2006 | 848 |
| 18 | The child sexual abuse accomodation syndrome | Child Abuse and Neglect | 1983 | 814 |
| 19 | Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer | Archives of General Psychiatry | 2011 | 806 |
| 20 | Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients | Kidney International | 2006 | 804 |
| 21 | The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome | Cell | 1993 | 782 |
| 22 | Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial | Lancet Respiratory Medicine,the | 2016 | 754 |
| 23 | The Limited Reliability of Physical Signs for Estimating Hemodynamics in Chronic Heart Failure | JAMA - Journal of the American Medical Association | 1989 | 750 |
| 24 | Phase III Randomized Clinical Trial Comparing Tremelimumab With Standard-of-Care Chemotherapy in Patients With Advanced Melanoma | Journal of Clinical Oncology | 2013 | 720 |
| 25 | Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study | Journal of Cerebral Blood Flow and Metabolism | 2005 | 694 |
| 26 | Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging | Annals of Neurology | 2000 | 663 |
| 27 | Enzyme-Replacement Therapy in Mucopolysaccharidosis I | New England Journal of Medicine | 2001 | 619 |
| 28 | Pulmonary Surfactant Therapy | New England Journal of Medicine | 1993 | 611 |
| 29 | Differential expression of cellular oncogenes during pre- and postnatal development of the mouse | Nature | 1982 | 562 |
| 30 | FDA-approved poly(ethylene glycol)–protein conjugate drugs | Polymer Chemistry | 2011 | 553 |
| 31 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 32 | Biogeographic Kinetics: Estimation of Relaxation Times for Avifaunas of Southwest Pacific Islands | Proceedings of the National Academy of Sciences of the United States of America | 1972 | 551 |
| 33 | A RANDOMIZED ACTIVE-CONTROLLED TRIAL OF MYCOPHENOLATE MOFETIL IN HEART TRANSPLANT RECIPIENTS1 | Transplantation | 1998 | 545 |
| 34 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 35 | Pathogenesis of Mucormycosis | Clinical Infectious Diseases | 2012 | 541 |
| 36 | Platelet Inhibition with Cangrelor in Patients Undergoing PCI | New England Journal of Medicine | 2009 | 533 |
| 37 | Esthesioneuroblastoma: a meta-analysis and review | Lancet Oncology, The | 2001 | 524 |
| 38 | Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study) | Lancet Oncology, The | 2008 | 520 |
| 39 | Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry | European Heart Journal | 2007 | 514 |
| 40 | Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial | Lancet, The | 2016 | 512 |
| 41 | Timeliness of Tissue-Type Plasminogen Activator Therapy in Acute Ischemic Stroke | Circulation | 2011 | 510 |
| 42 | Predictors of In-Hospital Mortality in Patients Hospitalized for Heart Failure | Journal of the American College of Cardiology | 2008 | 506 |
| 43 | Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer | JAMA Oncology | 2019 | 493 |
| 44 | Improved treatment of coronary heart disease by implementation of a Cardiac Hospitalization Atherosclerosis Management Program (CHAMP) | American Journal of Cardiology | 2001 | 479 |
| 45 | Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin | Hepatology | 1998 | 475 |
| 46 | Outcomes of bacterial meningitis in children | Pediatric Infectious Disease Journal | 1993 | 466 |
| 47 | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure | Nature Communications | 2020 | 466 |
| 48 | Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury | Journal of Clinical Investigation | 1999 | 458 |
| 49 | Size-selective collection of circulating tumor cells using Vortex technology | Lab on A Chip | 2014 | 457 |
| 50 | Prospective Long-Term Study of Vagus Nerve Stimulation for the Treatment of Refractory Seizures | Epilepsia | 2000 | 434 |
