| # | Title | Journal | Year | Citations |
|---|
| 1 | Natural RNA circles function as efficient microRNA sponges | Nature | 2013 | 6,415 |
| 2 | Mass spectrometry-based proteomics | Nature | 2003 | 6,282 |
| 3 | Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics | Molecular and Cellular Proteomics | 2002 | 4,931 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
| 6 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 7 | Plasmonics beyond the diffraction limit | Nature Photonics | 2010 | 3,408 |
| 8 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 9 | Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks | Cell | 2006 | 3,201 |
| 10 | Ageing populations: the challenges ahead | Lancet, The | 2009 | 2,804 |
| 11 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 12 | A generic protein purification method for protein complex characterization and proteome exploration | Nature Biotechnology | 1999 | 2,543 |
| 13 | Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics | Analytical Chemistry | 2003 | 2,337 |
| 14 | OARSI guidelines for the non-surgical management of knee osteoarthritis | Osteoarthritis and Cartilage | 2014 | 2,298 |
| 15 | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis | Lancet Oncology, The | 2010 | 1,915 |
| 16 | The Evolution and Future of Earth’s Nitrogen Cycle | Science | 2010 | 1,912 |
| 17 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 18 | Exponentially Modified Protein Abundance Index (emPAI) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides per Protein | Molecular and Cellular Proteomics | 2005 | 1,817 |
| 19 | Proteomic analysis of post-translational modifications | Nature Biotechnology | 2003 | 1,809 |
| 20 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 21 | Developmental neurotoxicity of industrial chemicals | Lancet, The | 2006 | 1,638 |
| 22 | Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis | New England Journal of Medicine | 2012 | 1,594 |
| 23 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 24 | Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study | Lancet, The | 2009 | 1,524 |
| 25 | A Comparison of Letrozole and Tamoxifen in Postmenopausal Women with Early Breast Cancer | New England Journal of Medicine | 2005 | 1,465 |
| 26 | Seagrass ecosystems as a globally significant carbon stock | Nature Geoscience | 2012 | 1,406 |
| 27 | Parts per Million Mass Accuracy on an Orbitrap Mass Spectrometer via Lock Mass Injection into a C-trap | Molecular and Cellular Proteomics | 2005 | 1,395 |
| 28 | Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns | Molecular and Cellular Proteomics | 2005 | 1,356 |
| 29 | Defining trained immunity and its role in health and disease | Nature Reviews Immunology | 2020 | 1,345 |
| 30 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 31 | The bibliometric analysis of scholarly production: How great is the impact? | Scientometrics | 2015 | 1,310 |
| 32 | The Danish Register of Causes of Death | Scandinavian Journal of Public Health | 2011 | 1,288 |
| 33 | Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease | Journal of the American College of Cardiology | 2016 | 1,254 |
| 34 | Proteomic characterization of the human centrosome by protein correlation profiling | Nature | 2003 | 1,204 |
| 35 | Qualitative description – the poor cousin of health research? | BMC Medical Research Methodology | 2009 | 1,202 |
| 36 | Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study) | Lancet, The | 2006 | 1,188 |
| 37 | The future of anaerobic digestion and biogas utilization | Bioresource Technology | 2009 | 1,182 |
| 38 | The Dalton quantum chemistry program system | Wiley Interdisciplinary Reviews: Computational Molecular Science | 2014 | 1,166 |
| 39 | Asthma | Lancet, The | 2018 | 1,105 |
| 40 | Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation | Molecular and Cellular Biology | 2007 | 1,097 |
| 41 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 42 | A review of innovation research in tourism | Tourism Management | 2010 | 1,052 |
| 43 | Analysis of Proteins and Proteomes by Mass Spectrometry | Annual Review of Biochemistry | 2001 | 1,044 |
| 44 | EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis | Annals of the Rheumatic Diseases | 2013 | 1,033 |
| 45 | Lipid rafts: at a crossroad between cell biology and physics | Nature Cell Biology | 2007 | 1,017 |
| 46 | European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice | Contact Dermatitis | 2015 | 1,012 |
| 47 | Valuing nature’s contributions to people: the IPBES approach | Current Opinion in Environmental Sustainability | 2017 | 1,007 |
| 48 | American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules - 2016 Update Appendix | Endocrine Practice | 2016 | 990 |
| 49 | Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2 | Science | 2006 | 967 |
| 50 | Organic carbon dynamics in mangrove ecosystems: A review | Aquatic Botany | 2008 | 966 |
