| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuropathic pain | Nature Reviews Disease Primers | 2017 | 1,360 |
| 2 | Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions | Journal of Periodontology | 2018 | 1,322 |
| 3 | Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions | Brain | 2009 | 1,219 |
| 4 | Ancient human genomes suggest three ancestral populations for present-day Europeans | Nature | 2014 | 1,179 |
| 5 | The human tumor microbiome is composed of tumor type–specific intracellular bacteria | Science | 2020 | 1,077 |
| 6 | Diagnosing lung cancer in exhaled breath using gold nanoparticles | Nature Nanotechnology | 2009 | 1,051 |
| 7 | Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database | Annals of the Rheumatic Diseases | 2010 | 1,017 |
| 8 | Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome | Pain | 2007 | 944 |
| 9 | Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial | Journal of Clinical Oncology | 2013 | 820 |
| 10 | Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease | Journal of Crohn's and Colitis | 2014 | 804 |
| 11 | Anthracycline Dose Intensification in Acute Myeloid Leukemia | New England Journal of Medicine | 2009 | 797 |
| 12 | Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review | European Journal of Cancer | 2016 | 733 |
| 13 | Perfusion-CT Assessment of Infarct Core and Penumbra | Stroke | 2006 | 722 |
| 14 | The Coagulopathy of Trauma: A Review of Mechanisms | Journal of Trauma | 2008 | 722 |
| 15 | Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial | Lancet, The | 2016 | 695 |
| 16 | Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions | Journal of Clinical Periodontology | 2018 | 673 |
| 17 | Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study | Journal of Clinical Oncology | 2019 | 671 |
| 18 | Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk | Pain | 2008 | 650 |
| 19 | Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors | British Journal of Cancer | 2010 | 638 |
| 20 | NMDA spikes in basal dendrites of cortical pyramidal neurons | Nature | 2000 | 628 |
| 21 | Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation | American Journal of Clinical Nutrition | 1995 | 603 |
| 22 | Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis | New England Journal of Medicine | 2012 | 588 |
| 23 | Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states | Current Opinion in Anaesthesiology | 2010 | 584 |
| 24 | Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews | New England Journal of Medicine | 2004 | 559 |
| 25 | International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP) | Pharmacotherapy | 2019 | 545 |
| 26 | Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines | World Journal of Emergency Surgery | 2020 | 533 |
| 27 | Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis | Lancet Infectious Diseases, The | 2016 | 528 |
| 28 | Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data | Lancet Respiratory Medicine,the | 2014 | 527 |
| 29 | Tissue Engineering of Vascularized Cardiac Muscle From Human Embryonic Stem Cells | Circulation Research | 2007 | 524 |
| 30 | The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA | Nature Genetics | 2001 | 521 |
| 31 | Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis | Nature Genetics | 2004 | 517 |
| 32 | Reduced Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice Following Consumption of Red Wine, or Its Polyphenols Quercetin or Catechin, Is Associated With Reduced Susceptibility of LDL to Oxidation and Aggregation | Arteriosclerosis, Thrombosis, and Vascular Biology | 1997 | 503 |
| 33 | Development of the Crohnʼs disease digestive damage score, the Lémann score | Inflammatory Bowel Diseases | 2011 | 496 |
| 34 | EANM/SNMMI Guideline for18F-FDG Use in Inflammation and Infection | Journal of Nuclear Medicine | 2013 | 496 |
| 35 | Review article: loss of response to anti-TNF treatments in Crohn’s disease | Alimentary Pharmacology and Therapeutics | 2011 | 495 |
| 36 | Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice | Autoimmunity Reviews | 2010 | 469 |
| 37 | International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer | Journal of Thrombosis and Haemostasis | 2013 | 469 |
| 38 | The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care | BMC Public Health | 2013 | 463 |
| 39 | Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy | Pain | 2012 | 461 |
| 40 | Childhood Obesity | Journal of Clinical Endocrinology and Metabolism | 2005 | 459 |
| 41 | 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer | Lancet Oncology, The | 2019 | 458 |
| 42 | Human Serum Paraoxonases (PON1) Q and R Selectively Decrease Lipid Peroxides in Human Coronary and Carotid Atherosclerotic Lesions | Circulation | 2000 | 447 |
| 43 | 2019 WSES guidelines for the management of severe acute pancreatitis | World Journal of Emergency Surgery | 2019 | 444 |
| 44 | Post-stroke dementia – a comprehensive review | BMC Medicine | 2017 | 442 |
| 45 | Summary of the Recommendations on Sexual Dysfunctions in Men | Journal of Sexual Medicine | 2010 | 431 |
| 46 | Colchicine poisoning: the dark side of an ancient drug | Clinical Toxicology | 2010 | 430 |
| 47 | Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus | Pain | 2013 | 428 |
| 48 | Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications | Current Medicinal Chemistry | 2010 | 416 |
| 49 | Mapping and predicting mortality from systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 410 |
| 50 | Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial | Lancet Infectious Diseases, The | 2018 | 400 |
